Navigation Links
University of Arizona researchers seek safer cystic fibrosis test
Date:9/10/2009

TUCSON, Ariz. Researchers from The University of Arizona Colleges of Pharmacy and Medicine are teaming up to try to invent a novel non-invasive lung test for cystic fibrosis sufferers.

Eric Snyder, PhD, assistant professor at the UA College of Pharmacy, is the principal investigator on the study, "Quantification of Exhaled Condensate Using Bronchoalveolar Lavage in Cystic Fibrosis." Dr. Snyder will work with UA College of Medicine faculty members Cori Daines, MD, and Wayne Morgan, MD, on the project.

Cystic fibrosis (CF) is a disease that affects the lung. According to the Cystic Fibrosis Foundation, about 30,000 children and adults in the United States (70,000 worldwide) suffer from CF. The disease results from a genetic alteration that lowers the function of chloride channels in the lung, which leads to a dry lung. The drier a CF patient's lungs, the more dangerous his or her disease.

The fluctuations of sodium, potassium and chloride in the lung all are important in keeping the lung wet and are of particular importance in cystic fibrosis. Studies in the past using cell lines or animal tissues have shown that the administration of a common drug used in cystic fibrosis, a beta-agonist, increases the amount of chloride on cells and this should help keep the lungs wet. The problem is that currently no easy way exists to measure the amount of chloride on a person's lung cells to optimize his or her therapy.

Today, measuring what is on lung cells requires an invasive test called bronchoalveolar lavage. Although bronchoalveolar lavage typically is used to determine the level of disease severity by exploring inflammatory markers, Dr. Snyder notes that it also could be used to collect signs of chloride, and possibly lung dryness.

During bronchoalveolar lavage, the patient is anesthetized and a tube is inserted into the lung. Next, a small amount of water is sprayed into the lung's airway and then sucked out through the tube. This fluid then can be analyzed for a variety of factors.

Bronchoalveolar lavage is invasive and carries some risk. The aim of Dr. Snyder's study is to develop a safer, non-invasive procedure that can measure some of the data that can be taken with a bronchoalveolar lavage with comparable accuracy.

The non-invasive procedure that Dr. Snyder's research will explore involves measuring signs of lung dryness by using a patient's breath that is condensed in a cooling chamber. To do this, the team first will have a patient breathe into a machine in Dr. Snyder's laboratory in the College of Pharmacy. Breathing on this machine condenses the patient's breath in a cooling chamber so that the research team can measure the amount of sodium, potassium and chloride it contains. Immediately after this non-invasive test, the patient will go to University Medical Center for a bronchoalveolar lavage performed under the direction of Drs. Daines and Morgan.

Once the brochoalveolar lavage is completed, the team will compare the amount of sodium, potassium, and chloride ions gathered in that test to the amount gathered non-invasively in the breath test. This will allow the team to see if the non-invasive test is as accurate as the invasive technique.

"This research will provide data to further explore the development of a non-invasive tool to measure airway fluid composition," says Dr. Snyder. "It will provide important preliminary data for future, larger studies in this patient population. Our goal is to invent a non-invasive test that will aid in the assessment and treatment of cystic fibrosis."


'/>"/>

Contact: Karin Lorentzen
lorentzen@pharmacy.arizona.edu
520-626-3725
University of Arizona, College of Pharmacy
Source:Eurekalert  

Related medicine news :

1. University of Iowa professor identifies new eating disorder
2. University of Wisconsin Hospitals and Clinics Complete System-Wide Conversion to Masimo SET Pulse Oximetry Technology
3. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
4. Tulane University to receive $14M for international HIV/AIDS program
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. Boston University School of Medicine researcher recipient of Memory Ride Grant
7. Loma Linda University Medical Center Selects Beryl to Manage Call Center Interactions for Womens Services Programs and Departments
8. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
9. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. George Mason University professor receives $2.6 million NIH grant to study Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Arizona researchers seek safer cystic fibrosis test
(Date:5/4/2016)... ... May 04, 2016 , ... Qualitative ... seeks to add a deeper understanding of the program, policy or intervention being ... answers different yet important questions. , In a new brief released today, Reading ...
(Date:5/4/2016)... SCOTTSDALE, AZ (PRWEB) , ... May 04, 2016 ... ... 2016 Annual Technology & Business Conference. The conference opened on Tuesday with Frank ... panel discussion on NCPDP’s PDMP Solution provided a deep dive on NCPDP’s model ...
(Date:5/4/2016)... ... May 04, 2016 , ... The RIDER Institute announces ... of DRACO broad-spectrum antiviral therapeutics. DRACOs have proven effective against all 18 viruses ... 2016 at http://igg.me/at/EndTheVirus and runs for 60 days, we are raising ...
(Date:5/4/2016)... ... May 04, 2016 , ... a2z, Inc. is ... and Canadian Association for Enterostomal Therapy (CAET) will be utilizing powerful and innovative ... to attendees and exhibitors for the 2016 WOCN Society & CAET Joint Conference—which ...
(Date:5/4/2016)... ... ... May kicked off with Melanoma Monday , a multi-agency effort to raise ... encouraging her patients, as well as residents all around Dallas, Cleburne, Irving, and Plano, ... in the future. , The dermatology-specific awareness month ends with “Don’t Fry Day,” established ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Research and Markets has ... Myeloma Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... Highlights 2016, provides comprehensive insights into Multiple ... Myeloma market valuations and forecast, Multiple Myeloma ...
(Date:5/3/2016)... PUNE, India , May 4, 2016 /PRNewswire/ ... report spreads across 154 pages, profiling 09 key ... It is a professional and in-depth study on ... providing a basic overview of the industry including ... Insulin Needles market analysis is provided for the ...
(Date:5/3/2016)... Pa. , May 3, 2016 ACME ... Jack Whelan and Delaware County ... (naloxone HCI) Nasal Spray in all ACME ... U.S. Centers for Disease Control and Prevention (CDC), naloxone has saved ... when police officers in Delaware County were ...
Breaking Medicine Technology: