Navigation Links
University Hospitals Case Medical Center cardiologists discover cancer risks in blood pressure meds
Date:6/13/2010

University Hospitals Case Medical Center cardiologists have uncovered new research showing an increased risk of cancer with a group of blood pressure medications known as angiotensin-receptor blockers (ARBs).

This class of drugs is used by millions of patients not only for high blood pressure but also for heart failure, cardiovascular risk reduction and diabetic kidney disease.

University Hospitals Harrington-McLaughlin Heart & Vascular Institute's Drs. Ilke Sipahi, Daniel I. Simon and James C. Fang recently completed a meta-analysis of over 60,000 patients randomly assigned to take either an ARB or a control medication. Their findings are published online today at The Lancet Oncology.

The researchers found that patients randomized to ARBs has "significantly increased risk of new cancer" compared to control patients.

"We have found the risk of new cancers was increased with these medications by 8-11 percent," said Dr. Ilke Sipahi, associate director of heart failure and transplantation and assistant professor at Case Western Reserve University School of Medicine. "Most importantly, risk of lung cancer was increased by 25 percent."

However, the research did not establish any link between ARBs and other types of cancer such breast cancer.

"This is the first time an association between ARBs and cancer development is suggested," Dr. Sipahi continued. "While our findings are robust, they need to be replicated in other studies before they can be considered as definitive."

Before this study, there were no major safety concerns with ARBs except for their use in pregnancy and in patients with chronic kidney or blockages of kidney arteries. Interestingly, previous animal studies with ARBs have been negative for cancer development.

"In medicine, physicians must balance the benefits and risks of all drug and device therapies," said Dr. Daniel Simon, director of the Harrington-McLaughlin Heart & Vascular Institute at University Hospitals Case Medical Center and professor at Case Western Reserve University School of Medicine. "We recommend that patients discuss the findings of this study with their physicians since ARBs are effective agents in the treatment of high blood pressure and heart failure. Meta-analyses are a powerful tool to look at low frequency safety signals, but require confirmation with other approaches, such as large national health and managed care registries."


'/>"/>

Contact: Mike Ferrari
mike.ferrari@uhhospitals.org
216-844-7239
University Hospitals Case Medical Center
Source:Eurekalert

Related medicine news :

1. University of Pennsylvania: Contrary to popular models, sugar is not burned by self-control tasks
2. Collagen manufactured from transgenic tobacco plants at Hebrew University
3. "How Facebook Makes Lonely People Even Lonelier" Revealed by Distinguished University of Chicago Professor in Interview with Brian Vaszily on IntenseExperiences.com
4. University Hospitals Case Medical Center experts present at ASCO Annual Meeting
5. Louisiana's First DNP Program Kicks Off Classes at Loyola University New Orleans
6. Maastricht University Medical Centre Advances Cranial Implant Technology with PEEK-OPTIMA
7. University of Minnesota, Mayo Clinic sign research pact with Karolinska
8. New research at the University of Leicester links shoplifting to your personality
9. University of Colorado Hospital Moving Forward with $400 Million Expansion
10. University Hospitals Neurological Institute earns Neuroscience Center of Excellence designation
11. Center for the Study of Aging established at University of Denver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... July 20, 2017 , ... The Business ... Body of Knowledge (BIZBOK® Guide )v 6.0 is now available for member download. ... through Guild collaborative teams. , Non-members may download the Part 1 Introduction ...
(Date:7/20/2017)... ... July 19, 2017 , ... Dr. Jig Patel is ... Schaumburg, IL, with or without a referral. Understanding the difficulties that face people who ... when they choose this permanent alternative to removable dentures and bridges. Not only does ...
(Date:7/20/2017)... ... ... A July 5th article on Reuters Health News discusses a ... body contouring procedure reported experiencing a better quality of life, compared to other patients. ... types of procedures, notes that this report jibes with what they regularly hear from ...
(Date:7/18/2017)... ... 2017 , ... Cognition Corporation , a software company ... of its “From the Helm” Webinar Series. , These sessions will focus ... CEO, the half-hour public webinars will take an in-depth look at applying usability ...
(Date:7/18/2017)... , ... July 18, 2017 , ... An inventor from ... quick and easy way to clean, scrub and moisturize the back and other hard-to-reach ... had surgery that limited movement in my upper body, particularly my shoulders. I found ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... on the development of oral drug delivery systems, announced ... has agreed to schedule an End-of-Phase II meeting with ... its oral insulin capsule ORMD-0801 in the treatment of ... and secondary endpoints by indicating a statistically significant lowering ...
(Date:7/10/2017)... -- The Institute for In Vitro Sciences (IIVS), a ... a VITROCELL® inhalation exposure system thanks to a generous ... which is designed to replace animals in inhalation testing, ... airborne test materials in an environment that mimics the ... testing combustible tobacco products, as well as next generation ...
(Date:7/10/2017)... -- The tenth annual BioPharm America™ will take ... the Sheraton Boston Hotel, September 26–27. The event will ... makers and innovative biotech startup companies. The event is ... impactful days. BioPharm America is now part of Biotech ... with 4,500+ life science industry influencers participating in 8+ ...
Breaking Medicine Technology: