Navigation Links
Universal flu vaccine study yields success in mice
Date:2/18/2011

Adelaide researchers have taken a step closer to the development of a universal flu vaccine, with results of a recent study showing that a vaccine delivered by a simple nasal spray could provide protection against influenza.

University of Adelaide researcher Dr Darren Miller and colleagues have successfully trialled a synthetic universal flu vaccine in mice. The results have appeared this month in a paper in the Journal of General Virology.

"Current flu vaccines rely on health authorities being able to predict what the forthcoming viral strain is going to be, and reformulating the vaccines each year accordingly. This is extremely time consuming, labor intensive and expensive, and it's something that a universal vaccine could overcome," Dr Miller says.

"A simple and totally synthetic universal vaccine one that is not derived from an influenza virus and does not require annual reformulation would have clear advantages in health clinics to control and prevent the spread of flu."

Dr Miller and colleagues used specific peptides delivered to the noses of mice. The peptides trigger an immune response to a tiny region of the flu virus that is present in all influenza A and B viruses, which effectively neutralizes the virus.

The test vaccine provided mice with 100% protection against a laboratory strain of virus (H3N2) and 20% protection against a highly pathogenic virus (H5N1, known as "bird flu"), which is consistent with the protection levels achieved with commercially available anti-influenza drugs.

"This is a positive response and one that shows promise for further testing both in laboratory and clinical settings," Dr Miller says.

He says that while the universal vaccine could be given as an injection, using a nasal spray has a number of advantages: "It is non-invasive and would be a preferred option for people afraid of needles. Importantly, a nasal spray stimulates local immune responses at the natural site of virus entry.

"This vaccine would also reduce the allergy risk for many patients because current flu vaccines are grown in eggs, those who are hypersensitive to eggs can't be vaccinated. Such a universal vaccine may also, of course, do away with the need for annual re-vaccinations, which is the situation many patients face today."


'/>"/>

Contact: Dr. Darren Miller
darren.miller@adelaide.edu.au
61-883-131-013
University of Adelaide
Source:Eurekalert

Related medicine news :

1. Universal Health Realty Income Trust Reports 2009 Fourth Quarter and Full Year Financial Results
2. Families Fighting Flu Commends the CDCs Advisory Committee on Immunization Practices Recommendation for Universal Influenza Vaccination
3. New York State Adopts Universal Provider Datasource to Reduce Administrative Costs for Medicaid
4. Universal Health Care Debate Coincides with Release of My eMHR, the Nation's First Free Electronic Personal Health Records System
5. Mount Sinai researchers move closer to a universal influenza vaccine
6. Mount Sinai researchers approaching universal treatment for all strains of influenza
7. Universal HIV testing and immediate treatment could reduce but not eliminate HIV/AIDS epidemic
8. Study shows universal surveillance for MRSA significantly decreased HAIs at PCMH
9. AIDS 2010 delegates and speakers unite in support of full funding for the Global Fund, the next milestone in drive for universal access
10. Government urges universal flu vaccinations
11. Experts recommend universal screening of newborns for congenital adrenal hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
(Date:9/12/2017)...  Consumer reviews on the independent review site Consumer Affairs ... company for hearing aids, ranking it higher than Miracle Ear ... ... For Hearing Aids ... online store that provides high performance, state-of-the-art, German-engineered hearing aids directly ...
Breaking Medicine Technology: