Navigation Links
Universal flu vaccine study yields success in mice
Date:2/18/2011

Adelaide researchers have taken a step closer to the development of a universal flu vaccine, with results of a recent study showing that a vaccine delivered by a simple nasal spray could provide protection against influenza.

University of Adelaide researcher Dr Darren Miller and colleagues have successfully trialled a synthetic universal flu vaccine in mice. The results have appeared this month in a paper in the Journal of General Virology.

"Current flu vaccines rely on health authorities being able to predict what the forthcoming viral strain is going to be, and reformulating the vaccines each year accordingly. This is extremely time consuming, labor intensive and expensive, and it's something that a universal vaccine could overcome," Dr Miller says.

"A simple and totally synthetic universal vaccine one that is not derived from an influenza virus and does not require annual reformulation would have clear advantages in health clinics to control and prevent the spread of flu."

Dr Miller and colleagues used specific peptides delivered to the noses of mice. The peptides trigger an immune response to a tiny region of the flu virus that is present in all influenza A and B viruses, which effectively neutralizes the virus.

The test vaccine provided mice with 100% protection against a laboratory strain of virus (H3N2) and 20% protection against a highly pathogenic virus (H5N1, known as "bird flu"), which is consistent with the protection levels achieved with commercially available anti-influenza drugs.

"This is a positive response and one that shows promise for further testing both in laboratory and clinical settings," Dr Miller says.

He says that while the universal vaccine could be given as an injection, using a nasal spray has a number of advantages: "It is non-invasive and would be a preferred option for people afraid of needles. Importantly, a nasal spray stimulates local immune responses at the natural site of virus entry.

"This vaccine would also reduce the allergy risk for many patients because current flu vaccines are grown in eggs, those who are hypersensitive to eggs can't be vaccinated. Such a universal vaccine may also, of course, do away with the need for annual re-vaccinations, which is the situation many patients face today."


'/>"/>

Contact: Dr. Darren Miller
darren.miller@adelaide.edu.au
61-883-131-013
University of Adelaide
Source:Eurekalert

Related medicine news :

1. Universal Health Realty Income Trust Reports 2009 Fourth Quarter and Full Year Financial Results
2. Families Fighting Flu Commends the CDCs Advisory Committee on Immunization Practices Recommendation for Universal Influenza Vaccination
3. New York State Adopts Universal Provider Datasource to Reduce Administrative Costs for Medicaid
4. Universal Health Care Debate Coincides with Release of My eMHR, the Nation's First Free Electronic Personal Health Records System
5. Mount Sinai researchers move closer to a universal influenza vaccine
6. Mount Sinai researchers approaching universal treatment for all strains of influenza
7. Universal HIV testing and immediate treatment could reduce but not eliminate HIV/AIDS epidemic
8. Study shows universal surveillance for MRSA significantly decreased HAIs at PCMH
9. AIDS 2010 delegates and speakers unite in support of full funding for the Global Fund, the next milestone in drive for universal access
10. Government urges universal flu vaccinations
11. Experts recommend universal screening of newborns for congenital adrenal hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... 2016 , ... The Pennsylvania Athletic Trainers’ Society (PATS) aired ... of 2016. The program was made possible by a Pennsylvania Department of Health ... and Human Services Administration. The broadcast, Use Your Head: Properly Managing Sport ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... pleased to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate ...
(Date:12/8/2016)... ... December 08, 2016 , ... David J. Dykeman , ... Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont ... and attorneys from the firm’s global Life Sciences & Medical Technology Group have been ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... has been recognized for adherence to the highest standards of trauma, maternity, ... organizations, announced the center's president and CEO, Dr. Daniel Messina. , Among the ...
(Date:12/8/2016)... San Francisco, California (PRWEB) , ... December 08, 2016 , ... ... health coaches, has raised an $18M Series B led by Canvas Ventures . ... use the capital to scale its mobile platform to serve more consumers who are ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Pa. , Dec. 9, 2016 Department ... announced temporary regulations for medical marijuana dispensaries under Act ... Pennsylvania Bulletin , and are now available online ... is needed in the plan for operation; process for ... dispensary; as well as where the dispensary facilities can ...
(Date:12/8/2016)... Calif. , Dec. 8, 2016 IRIDEX Corporation ... to offer newly issued shares of common stock, $0.01 par ... to an underwritten public offering.  The final terms of the ... time of pricing, and there can be no assurance as ... IRIDEX expects to use the net proceeds it will ...
(Date:12/8/2016)... NEW YORK , Dec. 8, 2016 ... ... such as reducing loss of blood during surgeries, lowering the ... surgeries, and decreasing risks of SSIs. The patient warming systems ... and intravascular warming systems.These benefits in turn reduce the stay ...
Breaking Medicine Technology: