Navigation Links
Universal flu vaccine study yields success in mice

Adelaide researchers have taken a step closer to the development of a universal flu vaccine, with results of a recent study showing that a vaccine delivered by a simple nasal spray could provide protection against influenza.

University of Adelaide researcher Dr Darren Miller and colleagues have successfully trialled a synthetic universal flu vaccine in mice. The results have appeared this month in a paper in the Journal of General Virology.

"Current flu vaccines rely on health authorities being able to predict what the forthcoming viral strain is going to be, and reformulating the vaccines each year accordingly. This is extremely time consuming, labor intensive and expensive, and it's something that a universal vaccine could overcome," Dr Miller says.

"A simple and totally synthetic universal vaccine one that is not derived from an influenza virus and does not require annual reformulation would have clear advantages in health clinics to control and prevent the spread of flu."

Dr Miller and colleagues used specific peptides delivered to the noses of mice. The peptides trigger an immune response to a tiny region of the flu virus that is present in all influenza A and B viruses, which effectively neutralizes the virus.

The test vaccine provided mice with 100% protection against a laboratory strain of virus (H3N2) and 20% protection against a highly pathogenic virus (H5N1, known as "bird flu"), which is consistent with the protection levels achieved with commercially available anti-influenza drugs.

"This is a positive response and one that shows promise for further testing both in laboratory and clinical settings," Dr Miller says.

He says that while the universal vaccine could be given as an injection, using a nasal spray has a number of advantages: "It is non-invasive and would be a preferred option for people afraid of needles. Importantly, a nasal spray stimulates local immune responses at the natural site of virus entry.

"This vaccine would also reduce the allergy risk for many patients because current flu vaccines are grown in eggs, those who are hypersensitive to eggs can't be vaccinated. Such a universal vaccine may also, of course, do away with the need for annual re-vaccinations, which is the situation many patients face today."


Contact: Dr. Darren Miller
University of Adelaide

Related medicine news :

1. Universal Health Realty Income Trust Reports 2009 Fourth Quarter and Full Year Financial Results
2. Families Fighting Flu Commends the CDCs Advisory Committee on Immunization Practices Recommendation for Universal Influenza Vaccination
3. New York State Adopts Universal Provider Datasource to Reduce Administrative Costs for Medicaid
4. Universal Health Care Debate Coincides with Release of My eMHR, the Nation's First Free Electronic Personal Health Records System
5. Mount Sinai researchers move closer to a universal influenza vaccine
6. Mount Sinai researchers approaching universal treatment for all strains of influenza
7. Universal HIV testing and immediate treatment could reduce but not eliminate HIV/AIDS epidemic
8. Study shows universal surveillance for MRSA significantly decreased HAIs at PCMH
9. AIDS 2010 delegates and speakers unite in support of full funding for the Global Fund, the next milestone in drive for universal access
10. Government urges universal flu vaccinations
11. Experts recommend universal screening of newborns for congenital adrenal hyperplasia
Post Your Comments:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: