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Universal flu vaccine clinical trials show promise
Date:6/7/2011

mately proven effective, VAX102 will meet this need and offer a completely new approach to global flu prevention and control."

Two studies, conducted at UTMB and Johnson County Clin-Trials in Lenexa, Kansas, assessed the safety, tolerability and immunogenicity the induced immune response of VAX102.

Healthy adults ages 18-49 were randomly assigned to receive two doses of either vaccine or placebo. The two studies established the dose range for further study. Doses ranging from 0.03 to 10 micrograms were studied. Individuals at the highest doses had more systemic reactions; doses of 1 microgram or less were safe. All vaccinated subjects showed some degree of antibody response, with a more than four-fold increase noted in all groups by 14 days after the second dose of vaccine.

An important next step will be studies to determine the degree to which the vaccine may be effective against influenza infection. Future studies would also investigate the durability of the antibody response and more closely assess cytokine responses proteins released as part of the immune response in an effort to better understand, predict and potentially prevent the adverse reactions noted at highest doses.

Pending results of future trials, VAX102 could be used as a stand-alone vaccine to prevent influenza A infection. Other possible strategies include use in conjunction with vaccines that target traditional influenza antigens, as a part of an approach to increase efficacy when infection occurs with mismatched strains.

VAX102 efficacy would have major global health implications, as worldwide annual influenza vaccination is not currently available due to limitations of licensed vaccines and international immunization infrastructure.

According to Turley, an influenza vaccine that can be produced rapidly and with great economies of scale, such as VAX102 through simple bacterial fermentation, allows for an entirely new approach to inte
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Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

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