Navigation Links
Univ. of Kentucky Sanders-Brown Center on Aging awarded Alzheimer's drug discovery research grant
Date:1/24/2011

LEXINGTON Ky. (Jan. 24, 2011) - Linda J. Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, has been awarded a $750,000 grant to further her research into a possible treatment for Alzheimer's disease. The grant is from the Edward N. And Della L. Thome Memorial Foundation, and was one of only eight Awards in Alzheimer's Disease Drug Discovery Research to be given in the U.S. in 2010.

Van Eldik's research project focuses on developing an orally active, small molecule drug to inhibit the protein kinase known as p38alphaMAPK. The protein stimulates overproduction of detrimental inflammatory molecules in the brain called proinflammatory cytokines. In normal brain activity, inflammatory and anti-inflammatory molecules operate together to keep brain functions in balance. In the brains of people who have Alzheimer's disease, this balance appears to be disrupted and the overproduction of proinflammatory cytokines leads to poor neuron function, and eventually symptoms of dementia.

Because inflammatory and anti-inflammatory molecules both serve important roles in normal brain function, it is not possible to treat Alzheimer's disease by turning off all inflammatory molecules in the brain. Rather, a successful compound must selectively target proteins like p38alphaMAPK that drive the disruptive inflammatory responses. Van Eldik's goal is to develop a selective small molecule drug to act on this culprit kinase to suppress overactive production of pro-inflammatory cytokines.

Successful so far in an animal model of Alzheimer's disease, Van Eldik's p38-targeted compounds have promise. The grant from the Thome Foundation will enable her to refine the best compound for possible use as a drug. Research will continue in cellular and animal models, as Van Eldik and her collaborators work to identify an optimal candidate drug for future clinical development and testing in humans.


'/>"/>

Contact: Allison Elliott
allison.elliott@uky.edu
University of Kentucky
Source:Eurekalert

Page: 1

Related medicine news :

1. Greenway Medical Technologies Donates Electronic Health Record, Clinical Research and Revenue Cycle Solutions to Northern Kentucky University
2. UIC Center for Research on Women and Gender receives Presidential Award
3. Beth Israel Deaconess Medical Center announces new AAAS Fellows
4. Oncology basic research director at John Theurer Cancer Center continues transplantation research
5. Many Survivors of World Trade Center Attacks Suffered PTSD: Study
6. Dana Farber/Harvard Cancer Center awarded $11.7M grant to support prostate cancer research
7. Collaboration offers NIH Clinical Center resources to Damon Runyon clinical investigators
8. UC Irvine Medical Center recognized for heart failure program
9. Novel therapy for metastatic kidney cancer developed at VCU Massey Cancer Center
10. Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say
11. John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... (PRWEB) September 02, 2014 NOVAtime ... Management solution development company, announced today that Avon ... 2009, has upgraded to NOVAtime 4000 Time ... conjunction with NOVAtime’s latest smart clock, the ... Farmington Valley of Connecticut is an award-winning nursing ...
(Date:9/2/2014)... FL (PRWEB) September 02, 2014 ... for about a decade, primarily to help people ... time, there are three developed systems,” says Dana ... approaches substantively differ, the goals are much the ... support of some type of harmonica.” , The ...
(Date:9/2/2014)... September 2014 – The days when skin care was ... shave daily – and commit common mistakes that can contribute ... inevitable, according to Joshua Fox, MD, medical director ... care was something in which only women seemed interested. But ... ages who realize that their fathers’ bare-bones routine of nicking ...
(Date:9/2/2014)... AURO the enterprise Canadian Public Cloud ... of its leadership team with the appointment of Kevin ... joins AURO in conjunction with his current role at ... the operations, product management and engineering teams to lead ... as ensuring effective internal and external controls are in ...
(Date:9/1/2014)... is one of the most loved online suppliers of ... quality and elegant floors, plywoods, veneers, fences and carpets. ... solid bamboo floors online. , As ... the new collection. BambooIndustry.com is also committed to offering ... and great customer services. Also, the company is considering ...
Breaking Medicine News(10 mins):Health News:Avon Healthcare Upgrades to NOVAtime 4000 Time and Attendance / Workforce Management Solution with NT7000 Smart Clocks 2Health News:Avon Healthcare Upgrades to NOVAtime 4000 Time and Attendance / Workforce Management Solution with NT7000 Smart Clocks 3Health News:Harmonica Techs, Inventor of the Pulmonica Pulmonary Harmonica, Outlines New Uses for Harmonicas in Healthcare 2Health News:Harmonica Techs, Inventor of the Pulmonica Pulmonary Harmonica, Outlines New Uses for Harmonicas in Healthcare 3Health News:Rough Isn’t Rugged in Men’s Skin: Dermatology specialist Dr. Joshua Fox with Advanced Dermatology PC offers tips on easy skin maintenance for men 2Health News:Rough Isn’t Rugged in Men’s Skin: Dermatology specialist Dr. Joshua Fox with Advanced Dermatology PC offers tips on easy skin maintenance for men 3Health News:AURO Appoints Kevin Liang as New Chief Financial Officer for Canadian Enterprise Public Cloud 2Health News:AURO Appoints Kevin Liang as New Chief Financial Officer for Canadian Enterprise Public Cloud 3Health News:BambooIndustry.com: Solid Bamboo Floors Provided At Discounted Rates 2
... , , , WASHINGTON, Sept. 17 ... today issued a joint Open Letter to Congress declaring that ... on Congress to act now on meaningful reforms. They state that ... our citizens now. , , The Open Letter ...
... , DALLAS, Sept. 17 For the ... Health Harris Methodist Hospital Southlake (THHMHS) one of the country,s 100 ... from an evaluation of 317 healthcare companies in partnership with Best ... programs nationwide. , , "Our vision ...
... , CARROLLTON, Ga., Sept. 17 /PRNewswire/ ... 11 th ( ) consecutive fiscal year ... Leader healthcare professional and provider conference. The conference, held in ... healthcare leaders, who participated in training and educational seminars designed to ...
... 17 The Damon Runyon Cancer Research Foundation ... , a run/walk and kids fun run at Yankee Stadium to support cancer ... of its kind to be held inside the new stadium, will support brilliant ... , , "This is a chance for New Yorkers and ...
... effects of cancer treatment, chemobrain a range of ... and other subtle cognitive changes following chemotherapy seriously ... a result, they have to adopt a range of ... lives. Breast cancer survivors tell their story ...
... ... the advisory board for PerfectServe, a healthcare communications company. , ... Knoxville, TN (PRWEB) Sept. 15, 2009 -- ... board for PerfectServe, a healthcare communications company. The board provides guidance on innovative ways ...
Cached Medicine News:Health News:Leading American Healthcare Experts Press Congress to Act Quickly on Health Reform 2Health News:Leading American Healthcare Experts Press Congress to Act Quickly on Health Reform 3Health News:Leading American Healthcare Experts Press Congress to Act Quickly on Health Reform 4Health News:Modern Healthcare Selects Texas Health Harris Methodist Hospital Southlake as One of the Best Places to Work in Healthcare 2Health News:Greenway Medical Technologies' PrimeLeader Conference Brings in Record Number of Customers as Company Continues Fast-Paced Growth 2Health News:Greenway Medical Technologies' PrimeLeader Conference Brings in Record Number of Customers as Company Continues Fast-Paced Growth 3Health News:Damon Runyon 5K Run/Walk at Yankee Stadium to Benefit Cancer Research 2Health News:Damon Runyon 5K Run/Walk at Yankee Stadium to Benefit Cancer Research 3Health News:Damon Runyon 5K Run/Walk at Yankee Stadium to Benefit Cancer Research 4Health News:Chemobrain -- the flip side of surviving cancer 2Health News:William Dwyer Named to PerfectServe Advisory Board 2
(Date:8/29/2014)... Aug. 29, 2014 Does your doctor know what ... doctors have recommended marijuana to the over 112,000 currently registered ... the majority of the other roughly 20,300+ active physicians listed ... little about it – even though a poll in February ... say they have tried it. "With marijuana ...
(Date:8/29/2014)... , Aug. 29, 2014 Diseases largely eradicated ... generation ago are returning. Measles was declared eliminated in ... 2014 as of August 15—the highest incidence in 20 ... health department declared whooping cough a problem of ... getting sick and dying from these preventable diseases—in part ...
(Date:8/29/2014)... 29, 2014  Abaxis, Inc. (NasdaqGS: ABAX ... and consumables to the medical, research and veterinary markets, ... Chief Executive Officer, will present at the CL King ... Tuesday, September 9, 2014 at 12:30 p.m. ET. The ... Hotel in New York City . ...
Breaking Medicine Technology:Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2
... PITTSBURGH, Nov. 9, 2011 Mylan Inc. (Nasdaq: ... to action in the global fight against HIV/AIDS. ... industry has made significant contributions toward making HIV/AIDS medicines ... to expanding access to treatment for more people. As ...
... N.J., Nov. 9, 2011 ProTron Technologies announces a ... systems through the patented Stethotron® Cerebral Stethoscope. ... brain aneurysm. In 50% of ruptured aneurysms, patients in ... One of the major factors leading to aneurysm ...
Cached Medicine Technology:Mylan Applauds Obama Administration's Call to Create an "AIDS-Free Generation" Through Global Fight Against HIV/AIDS 2
... Tissue Oximeter is a lightweight, portable console display ... with two separate channels for up to one ... well as adjustable alarms for low and high ... very user friendly and requires minimal training., ,Sensors ...
CO 2 SMO-Capnograph/Pulse Oximeter...
... Performance ,MARS Technology is the next generation ... an addition to our current family of ... advantage of new technological breakthroughs in signal ... pulse signal resulting in superior performance during ...
... Handheld Pulse Oximeter is a one-of-a-kind oximeter ... of the N-20PA has been shock-tested, vibration-tested ... it has even withstood the rigors ... for spot check measurements and also useful ...
Medicine Products: