Navigation Links
Univ. of Kentucky Sanders-Brown Center on Aging awarded Alzheimer's drug discovery research grant
Date:1/24/2011

LEXINGTON Ky. (Jan. 24, 2011) - Linda J. Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, has been awarded a $750,000 grant to further her research into a possible treatment for Alzheimer's disease. The grant is from the Edward N. And Della L. Thome Memorial Foundation, and was one of only eight Awards in Alzheimer's Disease Drug Discovery Research to be given in the U.S. in 2010.

Van Eldik's research project focuses on developing an orally active, small molecule drug to inhibit the protein kinase known as p38alphaMAPK. The protein stimulates overproduction of detrimental inflammatory molecules in the brain called proinflammatory cytokines. In normal brain activity, inflammatory and anti-inflammatory molecules operate together to keep brain functions in balance. In the brains of people who have Alzheimer's disease, this balance appears to be disrupted and the overproduction of proinflammatory cytokines leads to poor neuron function, and eventually symptoms of dementia.

Because inflammatory and anti-inflammatory molecules both serve important roles in normal brain function, it is not possible to treat Alzheimer's disease by turning off all inflammatory molecules in the brain. Rather, a successful compound must selectively target proteins like p38alphaMAPK that drive the disruptive inflammatory responses. Van Eldik's goal is to develop a selective small molecule drug to act on this culprit kinase to suppress overactive production of pro-inflammatory cytokines.

Successful so far in an animal model of Alzheimer's disease, Van Eldik's p38-targeted compounds have promise. The grant from the Thome Foundation will enable her to refine the best compound for possible use as a drug. Research will continue in cellular and animal models, as Van Eldik and her collaborators work to identify an optimal candidate drug for future clinical development and testing in humans.


'/>"/>

Contact: Allison Elliott
allison.elliott@uky.edu
University of Kentucky
Source:Eurekalert

Page: 1

Related medicine news :

1. Greenway Medical Technologies Donates Electronic Health Record, Clinical Research and Revenue Cycle Solutions to Northern Kentucky University
2. UIC Center for Research on Women and Gender receives Presidential Award
3. Beth Israel Deaconess Medical Center announces new AAAS Fellows
4. Oncology basic research director at John Theurer Cancer Center continues transplantation research
5. Many Survivors of World Trade Center Attacks Suffered PTSD: Study
6. Dana Farber/Harvard Cancer Center awarded $11.7M grant to support prostate cancer research
7. Collaboration offers NIH Clinical Center resources to Damon Runyon clinical investigators
8. UC Irvine Medical Center recognized for heart failure program
9. Novel therapy for metastatic kidney cancer developed at VCU Massey Cancer Center
10. Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say
11. John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., the ... (VLMS), is pleased to announce the appointment of ... of its Board of Directors and Chairman of ... enables life science companies to manage their entire ... of paper in this process. Furthermore, ValGenesis VLMS ...
Breaking Medicine Technology: