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United Therapeutics Reports 2008 Fourth Quarter and Annual Financial Results
Date:2/17/2009

$20,890 $8,570 $60,549 $38,459 License fees 150,000 - 150,000 11,013 Cancer 687 3,189 2,771 13,874 Infectious disease 725 278 1,556 824 Share-based compensation 4,918 3,671 16,200 12,373 Other 2,531 2,002 8,105 6,809 Total research and development expense $179,751 $17,710 $239,181 $83,352

Cardiovascular programs. During the three months ended December 31, 2008, expenses related to our cardiovascular programs increased over those for the three months ended December 31, 2007, as a result of the following:

  • Expenses associated with our inhaled and oral treprostinil programs increased by approximately $3.1 million. The increase in related expenditures corresponded to the progression of ongoing clinical trials, activities surrounding the unblinding of our FREEDOM-C trial of oral treprostinil and the filing of our application for marketing approval of inhaled treprostinil in the European Union;
  • We made milestone payments of $4.0 million and $2.0 million to Toray Industries, Inc. (Toray) and Aradigm Corporation (Aradigm), respectively, during the fourth quarter of 2008. These milestone payments were made in accordance with the terms of our agreements with Toray and Aradigm to develop and commercialize Toray's beraprost-MR for pulmonary arterial hypertension and Aradigm's AERx Essence for use with inhaled treprostinil;
  • Growth in our clinical staff to focus on new and investigational cardiovascular projects during 2008 resulted in a corresponding increase in salaries and related expenses of approximately $2.7 million for the fourth quarter of 2008; and
  • In December 2008, we made a one-time, upfront payment of $150.0 millio
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