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Unique role for blood formation gene identified
Date:9/12/2007

marrow failure occurred as early as 14 days after they induced the experimental loss of MLL, demonstrating the crucial role of MLL as necessary for both the development and maintenance of the bodys blood supply, according to the researchers.

We have shown that the adult blood-forming system depends on the continuous actions of MLL, Ernst said. Moreover, with the mouse model the scientists established to define normal MLL functions, they can begin exploring how to craft new anti-cancer treatments, she pointed out. We and other groups can start designing targeted therapies that inhibit cancerous forms of MLL that occur in childhood leukemia and do not affect normal MLL function, which, based on our studies in mice, would be fatal for the patient.


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Contact: Hali Wickner
dms.communications@dartmouth.edu
Dartmouth Medical School
Source:Eurekalert

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