Navigation Links
Unique protein bond enables learning and memory
Date:10/30/2012

AUGUSTA, Ga. Two proteins have a unique bond that enables brain receptors essential to learning and memory to not only get and stay where they're needed, but to be hauled off when they aren't, researchers say.

NMDA receptors increase the activity and communication of brain cells and are strategically placed, much like a welcome center, at the receiving end of the communication highway connecting two cells. They also are targets in brain-degenerating conditions such as Alzheimer's and Parkinson's.

In a true cradle-to-grave relationship, researchers have found the scaffolding protein, SAP102, which helps stabilize the receptor on the cell surface, binds with a subunit of the NMDA receptor called GluN2B at two sites, said Dr. Bo-Shiun Chen, neuroscientist at the Medical College of Georgia at Georgia Health Sciences University.

While one binding site is the norm, these proteins have one that's stronger than the other. When it's time for the normal receptor turnover, the stronger bond releases and the lesser one shuttles the receptor inside the cell for degradation or recycling.

"One binding site is involved in stabilizing the receptor on the cell surface and the other is important in removing the receptor. We think it's a paradigm shift; we've never thought about the same scaffolding protein having two roles," said Chen, corresponding author of the study in the journal Cell Reports.

"We believe by understanding the normal turnover of these receptors, we can learn more about how to prevent the abnormal receptor loss that occurs in debilitating diseases such as Alzheimer's." In Parkinson's, the receptors inexplicably move away from where the synapse, or information highway, connects to the neuron, making them less effective. NMDA receptors are supposed to cluster where the synapse hooks into the receiving neuron; in fact, it's part of what anchors the synapse, Chen said.

Interestingly, this pivotal p
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Moffitt researchers identify unique immune gene signature across thousands of patients solid tumors
2. How is grief unique to young adults with cancer?
3. Kings to develop unique sunscreen with Aethic
4. A CNIO team creates a unique mouse model for the study of aplastic anaemia
5. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
6. Brain Scans of Hoarders Show Unique Abnormalities
7. Heat-shock factor reveals its unique role in supporting highly malignant cancers
8. LA BioMed offers unique educational and research opportunity to local high school seniors
9. Unique program bringing electronic medical record data to ambulances lauded
10. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
11. Unique physiology key to diagnosing and treating diabetes in Asian populations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unique protein bond enables learning and memory
(Date:7/14/2014)... 14, 2014 Documented Legacy , a ... the publication of its first military memoir about a World ... Thursday in October 1943 and 19 months as a prisoner ... and build the American dream. , From the Top ... dream (Amazon) is a true life story of ...
(Date:7/14/2014)... 14, 2014 Seven promising startup ... healthcare problems have been accepted into the ... Accelerator (DHA). , The awardees were selected ... multi-stage process. They include Biomeme, Fitly, Life Patch, ... (from France) and Pulse InfoFrame (from Canada) —both ...
(Date:7/14/2014)... 2014 According to a new market ... (GaN, SiC, and Others), Devices (Power IC, Power Module ... Forecast to 2014 - 2020", the Power Electronics market ... power electronics market is valued at $36.86 Billion and ... 2014- 2020. The report also includes an in-depth analysis ...
(Date:7/14/2014)... Dallas, TX (PRWEB) July 14, 2014 ... transcatheter heart valves market in Americas. The analysis ... over the 2007–2020 period and key company share ... countries: US, Canada, Brazil and Mexico. It uses ... and secondary research and in-house analysis. , Scope, ...
(Date:7/14/2014)... July 13, 2014 (HealthDay News) -- Along with improving ... with Alzheimer,s disease and other types of dementia, a ... quality of life, the researchers said. "These preliminary ... of benefits for people with dementia and their loved ... of Case Western Reserve University and University Hospitals Case ...
Breaking Medicine News(10 mins):Health News:Mount Laurel-based Documented Legacy to Release Military Memoir of World War II Air Force Vet Who Survived Black Thursday Crash 2Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 2Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 3Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 4Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 2Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 3Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 4Health News:Power Electronics Market Estimated to Reach $36.86 Billion by 2020 at CAGR of 7.74% - New Report by MarketsandMarkets 5Health News:Americas Transcatheter Heart Valves Market 2020 Forecasts in New Research Report at LifeScienceIndustryResearch.com 2Health News:Americas Transcatheter Heart Valves Market 2020 Forecasts in New Research Report at LifeScienceIndustryResearch.com 3Health News:Americas Transcatheter Heart Valves Market 2020 Forecasts in New Research Report at LifeScienceIndustryResearch.com 4Health News:Cataract Surgery a Plus for Someone With Dementia, Study Says 2
... the McEwen Centre for Regenerative Medicine, Toronto General Hospital, researchers ... specific repair cells from the bone marrow to the affected ... been known that bone marrow cells have the ability to ... not been known until now is the critically important role ...
... that analyzed nearly 22,000 U.S men for a good 14 ... and keeping tabs on the body weight has an impact ... , ,Dr. Eric B. Rimm, co-author of the study, said ... be psychological, it has become clear that heart disease and ...
... Squibb has announced the launch of BARACLUDE? (entecavir) ... //following its approval by the Drug Controller General of ... treatment of chronic hepatitis B virus infection in adults ... of persistent elevations in serum aminotransferases (ALT or AST) ...
... into a leading diabetes management training center, not ... Afro-Asian countries//. The MV Hospital for Diabetes and ... Organization’s collaborating centre for diabetes research and training ... diverse countries as Cameroon, Tanzania, Myanmar, North Korea, ...
... rich in carbohydrates was very effective in maintaining weight loss ... be presented at the Australian //Institute of Food Science and ... conducted by the University of Melbourne research dietician Liz Delbridge ... for a period of 12 weeks. ,She and ...
... women with type 1 or 2 diabetes over a period ... of hip fracture among them//. This has helped to highlight ... population. ,According to Dr. Mohsen Janghorbani from Isfahan ... has not traditionally been considered a consequence of diabetes mellitus. ...
Cached Medicine News:Health News:Bone Marrow Cells Aid In Heart Repair 2Health News:Bone Marrow Cells Aid In Heart Repair 3Health News:India Approves Baraclude? (entecavir) For ,Treatment Of Chronic HEPATITIS B 2Health News:Diabetic Women Show Increased Risks of Hip Fracture 2
(Date:7/14/2014)... 2014  Remedy Informatics, the leading provider of ... life sciences research, announced that it has teamed ... build the first-ever national patient registry devoted to ... "The National Pancreas Foundation is a ... and committed organizations can effect upon society as ...
(Date:7/14/2014)... , July 14, 2014  Celsion Corporation (NASDAQ: ... that the Company will ring the NASDAQ Stock Market closing ... New York, NY . President ... the Celsion and EGEN management teams will participate in the ... ET.  A live webcast will be available at https://new.livestream.com/nasdaq/live ...
(Date:7/14/2014)... Minn. , July 14, 2014  Today, ATS ... announced that it acquired the assets of MicroTest Labs, ... The acquisition of MTL is the first step in ... chemistry laboratory services platform to support the medical device ... known as Accuratus Lab Services , a name ...
Breaking Medicine Technology:Remedy Informatics Partners with National Pancreas Foundation to Build a National Patient Registry 2Remedy Informatics Partners with National Pancreas Foundation to Build a National Patient Registry 3Celsion Corporation to Ring the NASDAQ Stock Market Closing Bell on July 16, 2014 2Celsion Corporation to Ring the NASDAQ Stock Market Closing Bell on July 16, 2014 3ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 2ATS Labs, Inc. Announces the Acquisition of MicroTest Labs, Inc. 3
... /PRNewswire-iReach/ -- Today Enroute Systems Corporation ... last mile postal service delivery service options for its ... existing support of multiple global and regional carrier parcel ... businesses and residences in over 220 countries through their ...
... 31, 2012 Medical Alarm Concepts Holding, Inc. (OTCQB: ... subsequent order as part of a large ongoing commitment ... purchase order, which will be delivered in monthly installments ... date. "In November 2011, we announced a ...
Cached Medicine Technology:Enroute Adds Last Mile Postal Service Delivery Services 2Enroute Adds Last Mile Postal Service Delivery Services 3Medical Alarm to Begin Fulfillment of MediPendant™ Against Largest Purchase Order - Announces Additional Warrant Cancellations 2Medical Alarm to Begin Fulfillment of MediPendant™ Against Largest Purchase Order - Announces Additional Warrant Cancellations 3Medical Alarm to Begin Fulfillment of MediPendant™ Against Largest Purchase Order - Announces Additional Warrant Cancellations 4