Navigation Links
Unique drug combination may hold the key to reversing Type I diabetes
Date:6/10/2008

epair cannot keep pace against the autoimmune response that is causing the diabetes.

In this study, diabetic mice were either given a placebo (saline) or treated with LSF, INGAP peptide, or LSF and INGAP together. The remission rate was most striking when mice were first treated with LSF in an effort to dampen the autoimmune system and then treated with the combination of LSF and INGAP peptide. This novel therapy resulted in a remission of diabetes in 70% of the mice after all treatments were withdrawn, including animals with very high blood glucose levels prior to treatment. Mice treated with INGAP peptide alone or INGAP peptide/LSF combinations averaged markedly higher levels of serum insulin after treatment than saline treated controls and were similar to non-diabetic mice. It was only when the combination of LSF and INGAP was used that a reversal of hyperglycemia was observed.

"These are very encouraging results," Nadler said. "Since both LSF and INGAP are already known to be safe, we should soon be able to begin testing the combination of LSF and INGAP in the clinic as a potential therapy for Type 1 diabetes in people soon."

Nadler was recruited to EVMS as part of a strategic initiative to expand the medical school's research capabilities in four areas where the state's eastern region has specific health needs and EVMS has existing research strengths, including: diabetes, cardiovascular disease, women's health/infant development, and cancer.

"Our ultimate goal is to improve the health of individuals by discovering novel approaches to the kinds of diseases that take a serious toll on the quality of life in our community and around the world," said Gerald J. Pepe, Ph.D., Dean and Provost of Eastern Virginia Medical School. "Dr. Nadler's work with LSF and INGAP is exactly the kind of innovative new therapy that we want to bring to fruition. Imagine the impact it would have to be able to reverse diabetes."


'/>"/>

Contact: Doug Gardner
gardneda@evms.edu
757-446-7070
Eastern Virginia Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Unique Simulation Training Course Ushers in New Era of Stroke Intervention
2. 2701 Australian: A Unique Partnership
3. Moonview Sanctuary Releases First Case Study of Client Treated Using Unique Moonview Model
4. Arctic explorer delivers unique snow-depth data for CryoSat
5. Study finds unique HIV vaccine formula elicits strong immune responses
6. Anthem Blue Cross and Blue Shield in New Hampshire Announces Unique Enhancement to its ePrescribing Program
7. Upscale Seattle-Based Skincare Clinic Expands Into California With Unique Custom Tailored Skincare Approach
8. Champion Health: Learn How to Create a Unique, Personalized Health Plan That Works and Keeps Working
9. Womans Abdominal Organs Removed in Unique Cancer Surgery
10. LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo
11. New World Record Holder in Powerlifting Credits NutraCeas Unique Rice-Bran-derived Product as his Secret Weapon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Ladies, it doesn't matter what your budget is, ... looking for an affordable gown can visit Discount-Dress.com ... get their dream items. Recently, the company has announced its ... Along with that, it is also providing great discounts for ... the deadline of this promotion is July 29, 2014. ...
(Date:7/11/2014)... July 12, 2014 According to ... total market is expected to register a CAGR ... , Browse 71 market data tables and 76 ... on "C4ISR Market"., http://www.marketsandmarkets.com/Market-Reports/c4isr-market-1315.html , Early ... http://www.marketsandmarkets.com/requestCustomization.asp?id=1315 , The report provides market ...
(Date:7/11/2014)... 11, 2014 (HealthDay News) -- Reducing the number of ... of Lyme disease and other tick-borne infections among people, ... populations can be manipulated to reduce human interactions with ... Lyme disease," the researchers wrote. White-tailed deer are ... Lyme disease to people. The study included nearly ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Microbiology testing ... the in-vitro diagnostics industry, which is expected to pose ... years. The sector owes its growth to the ongoing ... people’s health worldwide and a major factor leading to ... threat of bio-terrorism, and a broader availability of immunosuppressants, ...
(Date:7/11/2014)... Datalogic brings a new and innovative scanner to ... their new Gryphon GD4400 and GM4400 anti-microbial ... MRSA, which claimed 5,500 lives, becomes more preventable. ... the Gryphon GM4400-HC 2D readers can scan nearly all ... off of troublesome LCD monitors, smartphones, and other mobile ...
Breaking Medicine News(10 mins):Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 4Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 3Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3
... By Jenifer Goodwin HealthDay Reporter , FRIDAY, ... temporarily zaps away forehead wrinkles by freezing the nerves ... The technique, if eventually approved by the U.S. Food ... and Dysport. Both are injectable forms of Botulinum toxin ...
... April 2011: Exciting new data presented today at the ... chronic hepatitis C (HCV) patients suppressed the emergence of ... sustained virological response - undetectable HCV RNA - 12 ... study, HCV patients were given four drugs in combination; ...
... on the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer ... and presented updated results at the AACR 102nd Annual ... Heymach, M.D., Ph.D., associate professor of thoracic, head and neck ... Center, said this update details the "discovery phase" of the ...
... April 1 (HealthDay News) -- It,s important to keep injury ... Dr. Steven Greer, of the MCGHealth Sports Medicine Center in ... children. All children should undergo a physical examination before ... an extended period of time, they should begin increasing ...
... April 1 (HealthDay News) -- Updated guidelines to keep children ... released this week by the American Academy of Pediatrics. ... interests, skills and overall well-being, to ensure their child can ... to medically and mentally prepare their child for camp, and ...
... scientific discoveries in children,s health will be presented in Denver ... the Pediatric Academic Societies (PAS). This year,s gathering is a ... and more than 6,500 leaders in academic pediatrics from around ... Colorado Convention Center. Journalists will have access to ...
Cached Medicine News:Health News:Freezing Wrinkles a Possible Alternative to Botox 2Health News:Freezing Wrinkles a Possible Alternative to Botox 3Health News:Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment 2Health News:BATTLE researchers identify new biomarkers for EGFR inhibition 2Health News:Tips for Keeping Young Athletes Safe 2Health News:Pediatrics Group Offers Guidelines to Keep Young Campers Safe, Healthy 2Health News:Children's health is focus of annual meeting of Pediatric Academic Societies 2
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... "Global Hypodermic Needles Market 2014-2018" report to ... A hypodermic needle is a hollow needle ... the body or or to extract fluids from it. ... liquids or to inject substances that cannot be ingested. ...
(Date:7/11/2014)... , July 11, 2014 Research and ... of the "Immunoprotein Diagnostic Testing Market - ... highest CAGR of 6% and is expected to ... to their offering. ... diagnostic testing has been segmented according to immunoprotein ...
(Date:7/10/2014)... 11. Juli 2014  Dilon Technologies, ... die molekulare Bildgebung, einschließlich molekularer Bildgebung ... CE-Zulassung für sein Navigator ® -Gamma-Sondensystem ... das Produkt jetzt europaweit vertreiben. Dilon ... der europäischen Länder ausgedehnt und bereits ...
Breaking Medicine Technology:Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2
... NEW YORK, Jan. 25, 2011 Reportlinker.com ... is available in its catalogue: ... analysis of small molecule brand erosion post-patent ... IntroductionPharma is facing slowing ...
... 2011 Prolong Pharmaceuticals, which in October secured a ... today announced the signing of a long term lease ... and the formal addition of Dr. Hemant Misra to ... and Facilities Operations. The manufacturing facility ...
Cached Medicine Technology:Reportlinker Adds Brand Erosion Post-Patent Expiry - An analysis of small molecule brand erosion post-patent expiry 2Prolong Pharmaceuticals Leases 24,000-Square-Foot Manufacturing Facility, Adds Facilities Veteran to Executive Team 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: