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Unique change in protein structure guides production of RNA from DNA
Date:11/7/2013

ion of cells in general, the team's result stands to inform scientists about a variety of cellular processes. These include, for example, the mechanisms behind stem-cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

"However, there is still much we don't know about acetylation as it relates to transcription," said Dr. Ott. "For example, if CTD acetylation is important for stabilizing transcriptional pausing, why do we also see CTD acetylation at non-paused genes, although at different locations? Further, we believe there may be other steps in the transcription cycle that depend upon acetylation. Our most immediate goal is to find them. By doing so, we hope to deepen our understanding of one of nature's most elegant biological processes."


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Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

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Unique change in protein structure guides production of RNA from DNA
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