Navigation Links
Unique change in protein structure guides production of RNA from DNA
Date:11/7/2013

mammals, the researchers took a closer look.

The first breakthrough came when the research team identified a new type of modification, known as acetylation, which regulated transcription.

"Our next breakthrough occurred when we pinpointed the precise locations on the CTD where acetylation occurredand realized it was unique to higher eukaryotes," explained Sebastian Schrder, PhD, the paper's first author. "We then wanted to see how this mammalian-specific acetylation fit into the realm of polymerase pausing."

Now that the team knew where the CTD became acetylated, their next goal was to find out when. Clues to the timing of acetylation came in experiments where they mutated RNAPII so that CDT was unable to become acetylated. In these cases, the length of polymerase pausing dropped, and the necessary steps for the completion of transcription failed to occur. Additional experiments revealed the elusive timeline of acetylation and transcription.

"RNAPII binds to DNA to prepare for transcription. Shortly after that we see polymerase pausingat which point the CTD becomes highly acetylated," continued Dr. Shrder. "Soon after the pause, CTD is then deacetylatedthe original modification is reversedand transcription continues without a hitch."

Polymerase pausing is not unique to mammalsin fact it was characterized in HIV, the virus that causes AIDS, many years agobut the fact that the CTD becomes acetylated just before or during the time when transcription is paused appears to be unique. Drs. Ott and Schrder argue that CTD acetylation is a stabilizer, preparing RNAPII for efficient completion of transcription and slowing down the process to make sure everything is functioning correctlynot unlike the final 'systems check' a pilot must perform before takeoff.

These findings offer important insight into the relationship between acetylation and transcription. And given the importance of transcription in the growth and maturat
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. FDAnews Announces The FDA Unique Device Identification (UDI) Rule Virtual Conference
2. UC develops unique nano carrier to target drug delivery to cancer cells
3. Unique Collection of Charcoal Wedding Dresses Released By iFitDress.com
4. Healthy Directions & Dr. Sinatra Debut Omega-3 Joint Relief with Turmeric, a Unique Joint Supplement
5. US Hair Restoration Establishes a Unique and Advanced Training Program for Hair Transplant Technicians
6. Unique Dry Eye Relief Technology Builds Momentum with a New Global Patent
7. Zion Health Announces Unique Vegan Eco-Body Care Gifts for Women Now Available for Wholesale Orders for the Holidays
8. Tea Leaves Health and HealthPost Partner to Create Unique Offering to the Healthcare Industry
9. RAPS Releases New Edition of Unique Global Regulatory Affairs Reference Book
10. Diet Doc Hormone Diets & Weight Loss Plans Offers Uniquely Designed Prescription Hormone Diet Plans that Now Energize the Body Without Fattening Sugary Foods
11. Introducing an Innovative Method to Search for Term Life Insurance Online with Unique Internet Insurance Broker EQuote
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unique change in protein structure guides production of RNA from DNA
(Date:4/21/2014)... EAST LANSING, Mich. --- The most effective way ... at the start and keep them from growing. ... the Journal of Biological Chemistry , shows ... clumping, or aggregating, the first step of neurological ... Huntington,s disease. , The results are pushing the ...
(Date:4/20/2014)... A single type of cell in the lining ... invasive bladder cancer, according to researchers at the Stanford ... mice, is the first to pinpoint the normal cell ... It,s also the first to show that most bladder ... one cell, and explains why many human bladder cancers ...
(Date:4/18/2014)... a discovery that turns 160 years of neuroanatomy on ... known to be essential for the fast transmission of ... as ubiquitous as thought, according to a new work ... Cell Institute (HSCI) and the University,s Department of Stem ... Lichtman, of Harvard,s Department of Molecular and Cellular Biology. ...
(Date:4/18/2014)... made a brain-related discovery that could revolutionize doctors, ... discovery opens up the possibility that environmental and/or ... brain activity that the researchers have identified as ... of Neuroscience has just published a paper ... professor of psychology and his doctoral student John ...
(Date:4/17/2014)... PHILADELPHIA The presence of chronic inflammation in ... aggressive, prostate cancer, and this association was found ... levels, according to a study published in ... of the American Association for Cancer Research. , ... some participants of the placebo arm of the ...
Breaking Medicine News(10 mins):Health News:MSU physicists push new Parkinson's treatment toward clinical trials 2Health News:Stanford scientists identify source of most cases of invasive bladder cancer 2Health News:Stanford scientists identify source of most cases of invasive bladder cancer 3Health News:Stanford scientists identify source of most cases of invasive bladder cancer 4Health News:Stanford scientists identify source of most cases of invasive bladder cancer 5Health News:Finding turns neuroanatomy on its head 2Health News:Finding turns neuroanatomy on its head 3Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3
... for Cryopreservation of Cell-Based ... Melanoma Therapy, ... BLFS), a leading developer and marketer of,proprietary hypothermic storage and cryopreservation ... the,adoption of its products in the cellular therapy and cord blood ...
... Reesman, RN, Executive,Director, Passport Health Colorado, says far too ... types, leave,home without taking the basic steps she suggests ... into their health as they do into their,destination choice, ... 1) Get advice from a travel health professional. ...
... new standards, LENEXA, Kan., Mar. 26 ... of ClosedLoop(TM) clinical systems for,blood and medication management, ... Transfusion software for hospital,blood banks and LifeTrak(R) software ... global blood labeling standards being required in the,United ...
... 2008 Resources for Voters on Health Care and,Social ... Academy of,Actuaries said the most recent Medicare trustees, ... long-term financing issues.,According to the program,s trustees, Medicare,s ... taxes, and Medicare must,rely also on interest accrued ...
... Spheris, a leading global,outsource provider of clinical documentation technology ... months ended December 31, 2007., Financial Highlights-Fourth Quarter ... of 2007 were $48.6 million compared,with $51.4 million in ... net revenues during the fourth quarter of 2007 from ...
... March 26 FluoroPharma Inc., a company,developing ... Emission,Tomography (PET) market, announced that it has ... Hospital (MGH) for the development and,commercialization of ... (AD). The licensed technologies, which were co-developed ...
Cached Medicine News:Health News:BioLife Solutions Expands Presence in Cell Therapy and Cord Blood Banking Market Segments 2Health News:BioLife Solutions Expands Presence in Cell Therapy and Cord Blood Banking Market Segments 3Health News:The Top Ten Health Tips for International Travel 2Health News:ISBT 128 Labeling Implementation Date Looms for Blood Centers 2Health News:ISBT 128 Labeling Implementation Date Looms for Blood Centers 3Health News:Medicare Trustees' Report Highlights Need for Reform 2Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 2Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 3Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 4Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 5Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 6Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 7Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 8Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 9Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 10Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 11Health News:FluoroPharma Inc. Expands Technology Platform to Include Agents for Alzheimer's Disease (AD) 2
(Date:1/15/2014)... , Jan. 15, 2014  In an unprecedented effort to curb ... in ambulances and other transport vehicles, an advanced and portable UV ... personnel for the first time. In order to ... these deadly pathogens, West Palm Beach Fire ...
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: ... concerning composition of matter, biological targets, mechanism of action, ... This patent application describes a novel ... (VSRNAs) which interfere with the basic homeostatic cellular processes ...
(Date:1/15/2014)... GENEVA, Ill. , Jan. 15, 2014 The ... a Medical Fitness Center by the Medical Fitness Association, ... centers to achieve their full potential. The Cadence Fitness ... in the western suburbs and second in the Chicagoland ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... the quantitative determination of Immunoglobulin E ... atopic allergic diseases such as atopic ... been shown to exhibit increased total,immunoglobulin ... is also known as the,reagenic antibody. ...
...
...
...
Medicine Products: