Navigation Links
Unique Bone Marrow Transplant Said to Cure Sickle Cell
Date:11/14/2008

Technique is safe and effective, say Children's Hospital of Pittsburgh reseachers

FRIDAY, Nov. 14 (HealthDay News) -- A unique form of bone marrow transplantation is the only safe and effective cure for sickle cell disease, researchers at Children's Hospital of Pittsburgh report.

Traditional bone marrow transplants rely on heavy doses of chemotherapy prior to transplant in order to destroy a recipient's bone marrow so it won't reject the donated marrow. But that makes patients vulnerable to dangerous complications, something that's viewed as an unnecessary risk, because sickle cell disease typically isn't life-threatening, the researchers said.

This new transplant method relies on reduced intensity conditioning (RIC) regimens, which are less toxic to patients and eliminate life-threatening side effects generally associated with bone marrow transplantation. This means transplants can be offered to patients with severe sickle cell disease.

The researchers at Children's Hospital, part of the University of Pittsburgh Medical Center, reported that six of seven sickle cell patients who received RIC bone marrow transplants in the last decade now have donor marrow and are free of sickle cell disease symptoms.

The report was published in the November issue of the journal Biology of Blood and Marrow Transplantation.

"Bone marrow transplant is the only known cure for sickle cell disease. But doctors have avoided performing them in these patients, because complications from a traditional bone marrow transplant can be life-threatening," Dr. Lakshmanan Krishnamurti, a pediatric hematologist/oncologist and director of the Sickle Cell Program at Children's Hospital, said in a hospital news release. He helped develop RIC bone marrow transplants.

"Through the reduced-intensity approach we developed, the potential for complications is dramatically lessened. This study offers hope for a cure for thousands of patients with severe sickle cell disease," Krishnamurti said.

Sickle cell disease, an inherited blood disorder, affects about 80,000 people in the United States, primarily blacks. The disease can cause agonizing pain, strokes, damage to internal organs, and a shortened life expectancy.

More information

The March of Dimes has more about sickle cell disease.



-- Robert Preidt



SOURCES: Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, news release, Nov. 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Unique Holiday Gift for Animal Lovers: A Donation to Fund Animal Health Research; Pick a Favorite Animal - Dog, Cat, Horse, All Species of Wildlife
2. Former NBA and Boston Celtic Star Dee Brown Joins PrimeTime Sports, Boca Ratons Unique Sports Training Facility
3. New Stop Smoking Aid Offers Unique Teeth Whitening Benefit
4. Wolters Kluwer Healths Unique Prescription Data Tapped by FDA in Effort to Advance Drug Safety
5. The Maurer Foundation Promotes Breast Health Message With Unique Traveling Pink Bus
6. All-New Doctor.com Unites Powerful Doctor Search with Unique Social Media Features
7. Unique Way to Help Your Favorite Animal - Morris Animal Foundations 2009 Sponsorship Guide Provides Nearly 200 Options
8. Dr. Jan Linhart Now Offerring Unique Laser Teeth Whitening System
9. 2nd International Conference, Signs of Autism in Infants: Changing Outcomes Through Early Identification and Intervention, October 11 & 12, 2008; Unique and Critical Event
10. NIH launches unique effort to advance study of urologic chronic pelvic pain disorders
11. Arteries from distinct regions of the body have unique immune functions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unique Bone Marrow Transplant Said to Cure Sickle Cell
(Date:1/21/2017)... ... January 21, 2017 , ... Santa Rosa Orthopaedics (SRO) ... located at 167 Lynch Creek Way. The Petaluma office features three comfortable patient ... and rehabilitation services and on-site x-ray services. Two multi-specialist orthopaedic surgeons Dr. ...
(Date:1/20/2017)... ... January 20, 2017 , ... Spectrum Aquatics Launches New ADA Portable Motion Trek BP ... Since the lift is mounted on wheels, it can be wheeled out of the way ... to fasten to the deck. "We have transformed the feedback from customers into specific enhancements ...
(Date:1/20/2017)... ... January 20, 2017 , ... Source Vitál Apothecary, a skin and body care ... announced the company had a successful visit to the 2017 ECRM Diet, Vitamin & ... that work in the nutritional, sports and health industries a chance to meet in ...
(Date:1/20/2017)... Miami, Florida (PRWEB) , ... January 20, 2017 , ... ... in head lice cases in families with school-aged children since the holiday season. ... spend the holidays with their families, sharing hugs and taking photos, which is the ...
(Date:1/20/2017)... ... January 20, 2017 , ... Michael and Betsy Brauser celebrated ... Institute. For Betsy, the clinical trial has been life-saving as she has been ... , Betsy Brauser was diagnosed with ovarian cancer in 2009. She underwent standard ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Research and Markets has announced the ... and Future" report to their offering. ... This research service on the global ... and provides a snapshot of the key participants in the market. ... provided from 2016 to 2020. The market is expected to grow ...
(Date:1/20/2017)... Entscheidung fällt als ... Die internationale humanitäre Stadt soll um knapp 2800 m² ... Seine Hoheit Scheich Muhammad bin Raschid ... von Dubai , hat den Auftrag ... Humanitarian City IHC) zu verdreifachen, um den Betrieb zur ...
(Date:1/19/2017)... The global immunomodulators market is expected ... to a new study by Grand View Research, ... driven by high R&D investments employed by the ... new and therapeutically advanced drugs. This is believed ... unprecedented rate into the immunomodulators market hence providing ...
Breaking Medicine Technology: