Navigation Links
Unique Bone Marrow Transplant Said to Cure Sickle Cell
Date:11/14/2008

Technique is safe and effective, say Children's Hospital of Pittsburgh reseachers

FRIDAY, Nov. 14 (HealthDay News) -- A unique form of bone marrow transplantation is the only safe and effective cure for sickle cell disease, researchers at Children's Hospital of Pittsburgh report.

Traditional bone marrow transplants rely on heavy doses of chemotherapy prior to transplant in order to destroy a recipient's bone marrow so it won't reject the donated marrow. But that makes patients vulnerable to dangerous complications, something that's viewed as an unnecessary risk, because sickle cell disease typically isn't life-threatening, the researchers said.

This new transplant method relies on reduced intensity conditioning (RIC) regimens, which are less toxic to patients and eliminate life-threatening side effects generally associated with bone marrow transplantation. This means transplants can be offered to patients with severe sickle cell disease.

The researchers at Children's Hospital, part of the University of Pittsburgh Medical Center, reported that six of seven sickle cell patients who received RIC bone marrow transplants in the last decade now have donor marrow and are free of sickle cell disease symptoms.

The report was published in the November issue of the journal Biology of Blood and Marrow Transplantation.

"Bone marrow transplant is the only known cure for sickle cell disease. But doctors have avoided performing them in these patients, because complications from a traditional bone marrow transplant can be life-threatening," Dr. Lakshmanan Krishnamurti, a pediatric hematologist/oncologist and director of the Sickle Cell Program at Children's Hospital, said in a hospital news release. He helped develop RIC bone marrow transplants.

"Through the reduced-intensity approach we developed, the potential for complications is dramatically lessened. This study offers hope for a cure for thousands of patients with severe sickle cell disease," Krishnamurti said.

Sickle cell disease, an inherited blood disorder, affects about 80,000 people in the United States, primarily blacks. The disease can cause agonizing pain, strokes, damage to internal organs, and a shortened life expectancy.

More information

The March of Dimes has more about sickle cell disease.



-- Robert Preidt



SOURCES: Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, news release, Nov. 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Unique Holiday Gift for Animal Lovers: A Donation to Fund Animal Health Research; Pick a Favorite Animal - Dog, Cat, Horse, All Species of Wildlife
2. Former NBA and Boston Celtic Star Dee Brown Joins PrimeTime Sports, Boca Ratons Unique Sports Training Facility
3. New Stop Smoking Aid Offers Unique Teeth Whitening Benefit
4. Wolters Kluwer Healths Unique Prescription Data Tapped by FDA in Effort to Advance Drug Safety
5. The Maurer Foundation Promotes Breast Health Message With Unique Traveling Pink Bus
6. All-New Doctor.com Unites Powerful Doctor Search with Unique Social Media Features
7. Unique Way to Help Your Favorite Animal - Morris Animal Foundations 2009 Sponsorship Guide Provides Nearly 200 Options
8. Dr. Jan Linhart Now Offerring Unique Laser Teeth Whitening System
9. 2nd International Conference, Signs of Autism in Infants: Changing Outcomes Through Early Identification and Intervention, October 11 & 12, 2008; Unique and Critical Event
10. NIH launches unique effort to advance study of urologic chronic pelvic pain disorders
11. Arteries from distinct regions of the body have unique immune functions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unique Bone Marrow Transplant Said to Cure Sickle Cell
(Date:3/28/2017)... ... 28, 2017 , ... AutismOne announced the Board Certified in ... Medicine and available for application on Saturday, May 27, 2017, following Thursday, Friday, ... Springs. , Ed Arranga, president of AutismOne, stated: "Many of the modalities termed ...
(Date:3/28/2017)... ... 2017 , ... Public relations pros work hard to earn placements and ... While many results are clear, much of PR is hard to quantify. Goal-setting and ... to measurement, firms should always take an all-inclusive approach that takes both traditional and ...
(Date:3/28/2017)... ... 2017 , ... With expansion and efficiency in mind, Patten Seed Company completed ... processing plant opened in Marshallville in 2006, and a bagging and shipping facility has ... transition of Patten Seed operations to the Middle Georgia location from their previous home ...
(Date:3/28/2017)... ... 2017 , ... Oily skin is a common and unwelcomed occurrence in people of all ages, ... to offer to the discussion of dealing with excess skin oil. “Oily skin is a ... remedies that can help remove the oily shine while keeping the skin fresh and clean,” ...
(Date:3/28/2017)... ... 28, 2017 , ... Nurse practitioners and physician assistants are ... in the healthcare workforce, according to a survey recently released by PracticeMatch ... candidate leads to healthcare employers of physicians and advanced practice clinicians. , Only ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Calif. , March 27, 2017  Cryoport, Inc. ... that it intends to offer shares of common stock ... registration statement on file with the Securities and Exchange ... and other conditions, and there can be no assurance ... completed, or as to the actual size or terms ...
(Date:3/27/2017)... , March 27, 2017 ... attendees and more than 600 exhibitors from 70 ... opportunities and solutions that will advance the medical ... 2017 at the Messe Stuttgart, Stuttgart, ... medical technology platform showcasing the key trends and ...
(Date:3/27/2017)... , March 27, 2017  Sanderling Ventures, ... by Ethicon, a division of Johnson & Johnson. Torax ... for the treatment of gastro-esophageal reflux disease (GERD). ... augmentation (MSA) technology and the procedure is currently ... Torax Medical was founded by Sanderling ...
Breaking Medicine Technology: