Navigation Links
Unique Bone Marrow Transplant Said to Cure Sickle Cell
Date:11/14/2008

Technique is safe and effective, say Children's Hospital of Pittsburgh reseachers

FRIDAY, Nov. 14 (HealthDay News) -- A unique form of bone marrow transplantation is the only safe and effective cure for sickle cell disease, researchers at Children's Hospital of Pittsburgh report.

Traditional bone marrow transplants rely on heavy doses of chemotherapy prior to transplant in order to destroy a recipient's bone marrow so it won't reject the donated marrow. But that makes patients vulnerable to dangerous complications, something that's viewed as an unnecessary risk, because sickle cell disease typically isn't life-threatening, the researchers said.

This new transplant method relies on reduced intensity conditioning (RIC) regimens, which are less toxic to patients and eliminate life-threatening side effects generally associated with bone marrow transplantation. This means transplants can be offered to patients with severe sickle cell disease.

The researchers at Children's Hospital, part of the University of Pittsburgh Medical Center, reported that six of seven sickle cell patients who received RIC bone marrow transplants in the last decade now have donor marrow and are free of sickle cell disease symptoms.

The report was published in the November issue of the journal Biology of Blood and Marrow Transplantation.

"Bone marrow transplant is the only known cure for sickle cell disease. But doctors have avoided performing them in these patients, because complications from a traditional bone marrow transplant can be life-threatening," Dr. Lakshmanan Krishnamurti, a pediatric hematologist/oncologist and director of the Sickle Cell Program at Children's Hospital, said in a hospital news release. He helped develop RIC bone marrow transplants.

"Through the reduced-intensity approach we developed, the potential for complications is dramatically lessened. This study offers hope for a cure for thousands of patients with severe sickle cell disease," Krishnamurti said.

Sickle cell disease, an inherited blood disorder, affects about 80,000 people in the United States, primarily blacks. The disease can cause agonizing pain, strokes, damage to internal organs, and a shortened life expectancy.

More information

The March of Dimes has more about sickle cell disease.



-- Robert Preidt



SOURCES: Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, news release, Nov. 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Unique Holiday Gift for Animal Lovers: A Donation to Fund Animal Health Research; Pick a Favorite Animal - Dog, Cat, Horse, All Species of Wildlife
2. Former NBA and Boston Celtic Star Dee Brown Joins PrimeTime Sports, Boca Ratons Unique Sports Training Facility
3. New Stop Smoking Aid Offers Unique Teeth Whitening Benefit
4. Wolters Kluwer Healths Unique Prescription Data Tapped by FDA in Effort to Advance Drug Safety
5. The Maurer Foundation Promotes Breast Health Message With Unique Traveling Pink Bus
6. All-New Doctor.com Unites Powerful Doctor Search with Unique Social Media Features
7. Unique Way to Help Your Favorite Animal - Morris Animal Foundations 2009 Sponsorship Guide Provides Nearly 200 Options
8. Dr. Jan Linhart Now Offerring Unique Laser Teeth Whitening System
9. 2nd International Conference, Signs of Autism in Infants: Changing Outcomes Through Early Identification and Intervention, October 11 & 12, 2008; Unique and Critical Event
10. NIH launches unique effort to advance study of urologic chronic pelvic pain disorders
11. Arteries from distinct regions of the body have unique immune functions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unique Bone Marrow Transplant Said to Cure Sickle Cell
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... PARIS and NEW YORK , Sept. 12, ... ethical performance ratings for global supply chains, has published the first annual ... the CSR performance of more than 20,400 companies evaluated by EcoVadis, based ... years 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
Breaking Medicine Technology: