Navigation Links
Unhooking the Obesity-Diabetes Connection
Date:7/26/2009

Understanding the link may someday lead to a cure, studies suggest

SUNDAY, July 26 (HealthDay News) -- Scientists may be closer to solving a medical mystery with huge implications for personal and public health: Why obese people are prone to developing type 2 diabetes.

A series of studies appearing online July 26 in Nature Medicine suggest that inflammation within the fat tissues of heavy individuals could trigger the blood sugar disease.

What's more, each of the four completely independent studies, from two continents and three countries, showed that interfering with these immune-cell processes actually reversed diabetes in mice.

The long-term implications of the findings are enticing: perhaps one day a cure for type 2 diabetes, a condition that now plagues more than 23 million people in the United States alone.

"This group of papers suggests that cellular immunity may regulate inflammation in fat," said Dr. Vivian Fonseca, professor of medicine at Texas A&M Health Science Center College of Medicine and director of the Diabetes Institute at Scott & White. "The authors do suggest that if you change the inflammatory response by changing the way the body cells respond to a trigger for inflammation, you might be able to get at the real heart of diabetes and that suggests you could cure it."

But Fonseca warned, all these studies were conducted in mice and have yet to be proven in humans

In type 2 diabetes, the body often becomes resistant to insulin and doesn't use it effectively. In the last decade or so, researchers have presented evidence that suppressing inflammation in animals could improve insulin resistance and other processes involved with diabetes. Inflammation is now widely believed to be involved in many metabolic diseases afflicting obese individuals. Inflammation in fat tissue, in particular, seems to be a culprit, by changing fat tissue function, thereby contributing to insulin resistance.

But the exact mechanisms of the phenomenon have been unclear.

Three papers, one from Japan, one from Canada and one from the United States, showed that immune system cells known as T cells were deficient in obese mice, pushing the immune system to somehow initiate insulin resistance.

Restoring T cells to more normal levels actually reversed weight gain and improved insulin resistance, even when the mice continued on a high-fat diet.

The fourth study looked at another class of immune cells called mast cells, which are more commonly linked to allergies.

An over-abundance of mast cells contributed to obesity and diabetes in mice, but when mast cells were removed from the system the problem was corrected, explained study senior author Guo-Ping Shi, a biochemist with Brigham and Women's Hospital in Boston.

"We gave mice a high-fat diet for three months and they developed obesity and diabetes," he said. But mice that had been stripped of mast cells did not. "These mice are protected from the disease if they are without these cells," Shi said.

Shi's team also gave wild-type ("normal") mice allergy medicines, which work to "stabilize" mast cells. This also led to improvements in the mice.

"We can use the drugs to manipulate cell activity or prevent disease in this case," Shi said.

Shi said he has signed a contract with a local company to develop a version of the drugs to combat diabetes in humans.

More information

There's more on type 2 diabetes at the American Diabetes Association.



SOURCES: Guo-Ping Shi, D.Sc., biochemist, Brigham and Women's Hospital, Boston; Vivian Fonseca, M.D., professor, internal medicine, Texas A&M Health Science Center College of Medicine, chief, endocrinology, and director, Diabetes Institute, Scott & White; July 26, 2009, Nature Medicine, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mylan Commences Tender Offers and Consent Solicitations for Its 5.750% Senior Notes Due 2010 and 6.375% Senior Notes Due 2015 in Connection With Its Proposed Acquisition of Mercks Generic Pharmaceutical Business
2. NIH awards $10.8M to Columbia to study connection between diabetes and heart disease
3. Vitasoy Promotes the Soy Breast Health Connection
4. Randy Jackson and the American Heart Association Promote Awareness about the Connection Between Type 2 Diabetes and Cardiovascular Disease
5. Research examines connection between substance abuse and violence
6. Bestselling Author Dr. Timothy Brantley Explains the Connection of Food and Mood
7. Study finds no connection between vitamin D and overall cancer deaths
8. Free Seminar Features State Funds Back Connection(TM), November 14, in Chico
9. Free Seminar Presents State Funds Back Connection(TM), November 13, in Redding
10. Hormonal Changes and Depression: What is the Connection?
11. Cypak Compliancy Connection Powers Stora Enso Pharma DDSi
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unhooking the Obesity-Diabetes Connection 
(Date:2/23/2017)... Denver, Colorado (PRWEB) , ... February 23, 2017 ... ... Dialog Magazine, an exciting, new, interactive publication where generations converge and explore the ... to expand their worldview, Dialog Magazine enables readers to gain understanding, increase empathy, ...
(Date:2/23/2017)... ... (PRWEB) February 23, ... the nation to come together to combine its favorite springtime ... its favorite fruit – apples! To celebrate National Nutrition Month, ... the “Apple Madness” bracket tournament – a five-week, five-round online ...
(Date:2/23/2017)... ... 23, 2017 , ... Thomas Vas-Don suffered from severe injury due ... was able to successfully recover. In “ Origin & Insertion Charts for Massage Therapists ... the principals of massage, anatomy , trigger points and referral pain patterns ...
(Date:2/22/2017)... ... February 22, 2017 , ... Stem cell therapy has ... technology is so cutting edge, in fact, the U.S. Food and Drug Administration ... However, successful patient outcomes in certain clinical stem cell procedures have shown that ...
(Date:2/22/2017)... ... 2017 , ... Giving patients with diabetes customized coaching sessions, ... hospital admissions, and better blood pressure and glycemic control, a new study ... be found here . , The study comes as health plans increasingly ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017 Research and ... Analysis and Strategies - 2016" report to their offering. ... The latest research ... data and benchmarks in the global Fibromyalgia market. The ... the key drugs marketed for Fibromyalgia and their clinical attributes? How ...
(Date:2/23/2017)... , Feb 23, 2017 Research and Markets ... & Trends - Industry Forecast to 2025" report to their ... The ... around 6.9% over the next decade to reach approximately $47.6 billion ... estimates and forecasts for all the given segments on global as ...
(Date:2/23/2017)...  MiMedx Group, Inc. (NASDAQ: MDXG), the leading regenerative ... to develop and market advanced products and therapies for ... and Dental sectors of healthcare, today announced its record ... December 31, 2016. Full Year 2016 Highlights ... increase over full year 2015 revenue ...
Breaking Medicine Technology: