Navigation Links
Unexpectedly small effects of mutations in bacteria bring new perspectives
Date:11/5/2010

Most mutations in the genes of the Salmonella bacterium have a surprisingly small negative impact on bacterial fitness. And this is the case regardless whether they lead to changes in the bacterial proteins or not. This is shown by Uppsala University scientists in an article being published today in the prestigious journal Science.

The researchers have examined the impact of mutations on the rate of growth of the Salmonella bacterium and show that most mutations have generally very small effects. Moreover the negative effects are of the similar magnitude for changes that lead to substitution of amino acids in proteins (so-called non-synonymous mutations) as for mutations that do not change the protein sequence (so-called synonymous mutations).

"The findings open an entirely new chapter for experimental studies of mutations and show that we need to change our view of how mutations lead to negative effects," says Professor Dan Andersson, lead author of the study.

A central question in evolutionary biology, medical genetics, species-conservation biology, and animal breeding is how and why mutations affect an organism's capacity to survive. Usually these questions are studied in DNA sequence analyses from which conclusions have been drawn about what mutations are most common and have become established in the DNA of the organism.

The Uppsala scientists have used another -- experimental -- method whereby they can use various genetic tricks to introduce random individual mutations into any chosen gene, a method that has previously been used primarily in viruses. Two genes that code for proteins that are included in ribosomes were mutated, and using extremely sensitive growth measurements, doctoral candidate Peter Lind showed that most mutations reduced the rate of growth of bacteria by only 0.500 percent. No mutations completely disabled the function of the proteins, and very few had no impact at all.

<
'/>"/>
Contact: Dan Andersson
Dan.Andersson@imbim.uu.se
46-018-471-4175
Uppsala University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
2. Small particles show big promise in beating unpleasant odors
3. Small business success spotlighted by USDA at conference
4. American Chemical Society Webinar focuses on NSFs small business funding programs
5. Health Care Reform Helps Small Businesses Offer Coverage: Report
6. 16.6 million small business employees could benefit from ACA provisions starting this year
7. Babies Born Late May Face Small Cerebral Palsy Risk
8. Small Amounts of Dark Chocolate May Guard Against Heart Failure
9. Henry Ford Hospital study: Donor Risk Index does not impact outcomes on a small scale
10. Small increases in vaccine cost can cause large gaps in protection
11. Smaller hospitals can provide safe and high-quality surgical care comparable to larger counterparts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Aaron Marshall, Corporate Counsel at Northrop Grumman, will serve ... for the 2014-2015 fiscal year. He joined the Board ... "“Serving on the HASA board has given me a broader, ... remember how much others need help." , ABOUT AARON MARSHALL:, ... a B.S. in Finance from the University of Delaware. Currently, ...
(Date:7/22/2014)... The American Society of Hematology (ASH) will honor ... Los Angeles with the 2014 E. Donnall Thomas ... the discovery of the iron-regulatory hormone hepcidin and investigation ... after the Nobel Prize Laureate and past Society president ... hematology that have represented a paradigm shift or significant ...
(Date:7/22/2014)... Robert E. Marc, Ph.D., director of research at the ... been named by the International Society of Eye Research ... Research Foundation,s 2014 Paul Kayser International Award in Retina ... scientist who has made a significant contribution to the ... being presented this week at the ISER Biennial Meeting ...
(Date:7/22/2014)... As reported on July 17, 2014 by ABC ... her favorite beauty products, “ Botox , that’s pretty much ... Botox has changed my life” by halving the amount ... her various, daily appearances. “Suddenly my eyelids are no ... , “I think that Kelly Ripa’s response to the question ...
(Date:7/22/2014)... Latin American Conference on Lung Cancer (LALCA 2014) will ... Peru. , Lung Cancer is still the leading cause ... Building on the success of the previous conferences in ... will discuss the science and advances in the treatment ... and Latin America in particular. , With tobacco being ...
Breaking Medicine News(10 mins):Health News:New Board President for Baltimore-based Nonprofit 2Health News:Tomas Ganz, M.D., Ph.D., to present 2014 ASH E. Donnall Thomas Lecture 2Health News:Tomas Ganz, M.D., Ph.D., to present 2014 ASH E. Donnall Thomas Lecture 3Health News:University of Utah researcher Robert Marc receives Paul Kayser International Award 2Health News:Celebrity Botox: Kelly Ripa Confesses to Getting Botox Injections 2
... human body, HOUSTON, Sept. 25 Can you ... Simply visit The John P. McGovern Museum of Health ... explore the latest,exhibit -- Sesame Street Presents: The Body ... October 4, 2007 and January 13, 2008.,The exhibit offers ...
... 25 A Place for Mom, the nation,s largest,referral ... that John,Temple, Chief Operating Officer was named to the ... The 40 Under 40 List is the Pacific Northwest ... They look for,nominees that work hard to drive the ...
... Phase II data presented today suggest that ZD4054, a ... with Hormone Resistant Prostate Cancer (HRPC), could offer a ... HRPC who were asymptomatic or mildly symptomatic for pain.1 ... percent reduction in the risk of death compared to ...
... 25 ThermoSpas, the country,s,largest hot tub retailer, ... chronically,ill children to give specially-designed therapeutic hot tubs ... program, the company will donate 12,ThermoSpas hot tubs ... who will benefit,from warm water therapy. ThermoSpas encourages ...
... Continuum Health Partners Selects Ericom(R) PowerTerm(R) WebConnect for ... ... 25 Continuum Health Partners, a,New York-based non-profit hospital system, ... of Continuum,s strategy to,provide doctors and staff with secure, on-demand ...
... youngsters to stay healthy, , , TUEDAY, Sept. 25 (HealthDay News) ... and way too much junk food are pushing U.S. children ... new studies finds. , The studies -- published in a ... -- show the myriad challenges youngsters face every day ...
Cached Medicine News:Health News:Sesame Street Exhibition Makes Texas Premier at The Health Museum 2Health News:Sesame Street Exhibition Makes Texas Premier at The Health Museum 3Health News:Sesame Street Exhibition Makes Texas Premier at The Health Museum 4Health News:Sesame Street Exhibition Makes Texas Premier at The Health Museum 5Health News:Sesame Street Exhibition Makes Texas Premier at The Health Museum 6Health News:A Place for Mom COO Makes Seattle's 40 Under 40 List 2Health News:Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054 2Health News:Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054 3Health News:Photos: America's Chronically Ill Children Have New Hope with 'Hot' Gift 2Health News:Ericom Provides Significant Cost-Savings for Major New York City Healthcare Organization 2Health News:Junk Food, TV Driving Kids to Obesity 2Health News:Junk Food, TV Driving Kids to Obesity 3Health News:Junk Food, TV Driving Kids to Obesity 4
(Date:7/22/2014)... July 22, 2014 The National Space Biomedical ... Center for Space Radiation Research (CSRR) under the leadership ... an Associate Professor of Pharmaceutical Sciences within the University ... Division of Radiation Health. She is located in ... a team of investigators working across four U.S. institutions, ...
(Date:7/22/2014)... , July 22, 2014  Decision Resources Group finds that ... Canada will remain relatively stagnant at a value ... fact that percutaneous coronary intervention (PCI) volumes are growing faster ... markets, such as the United States ... largely driven by the increase in penetration of PCI procedures ...
(Date:7/22/2014)... July 22, 2014  Decision Resources Group finds ... (MS) patients currently treated with Biogen Idec,s ... experienced flushing and/or gastrointestinal events while on ... currently experiencing these side effects, signifying either ... management of such events. In the end, ...
Breaking Medicine Technology:Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 3The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 2The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 3Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 2Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 3
... 14 New England Biolabs (NEB) has launched ... to simplify DNA methylation analysis for epigenetics researchers. ... of the current methods, including the lack of ... of 5-hydroxymethlcytosine (5-hmC) in the epigenome. ...
... Fe and Femcon® Fe... -- ARDEE, Ireland, Oct. 14 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... { var s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
Cached Medicine Technology:New England Biolabs Launches a Suite of Innovative Tools to Advance Epigenetics Research, Including PCR-Based Assay to Identify and Quantitate 5-hmC in Epigenome 2Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 2Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 3Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 4Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 5Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 6Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 7Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 8Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 9Warner Chilcott Announces Settlement with Lupin of Loestrin® 24 Fe and Femcon® Fe Patent Litigations 10
... The CKX microscopes utilize the ... visibility and operability in cell ... cost-effective inverted microscope suited to ... of fields--from tissue culture and ...
Continuous rocking motion graphic display....
Stainless steel lockable wall display for up to 12 frames....
Omni labs carries an extensive line of frames, lenses, soft contacts, RGP lenses, and many other products and services. It supports Zeiss, American optical, Sola, Rodenstock, Zylowear, Eyewear design...
Medicine Products: