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Unexpected toughness may mark out cancer cells in the blood
Date:12/4/2012

f these various, separate molecular abnormalities.

If that is true, simply measuring cancer cells' ability to resist fluid shear stresses might allow researchers to examine the behavior of cancer cells and investigate the effects of cancer drugs on tumor cells.

Translating to clinical

With the surprising findings and their potential for clinical use, the study has grown from a side project of study author and then-graduate student J. Matthew Barnes, and has now garnered external funding to support further research. Jones Nauseef, study author and a UI MSTP student in Henry's lab, has taken up the research, and Henry has established a collaboration with UI urologist James Brown, M.D., to test the technique with blood samples from patients with prostate cancer. That study is being funded by a grant from the Department of Defense.

"A next step for us is to translate these findings into patient specimens and determine whether this can be useful in a context that is clinically meaningful," Henry says, such as determining whether a cancer is progressing or if it may respond to a particular therapy.


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Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert  

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