Navigation Links
Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding
Date:12/13/2011

Cold Spring Harbor, NY -- Something rotten never smelled so sweet.

This is what members of a team of scientists at Cold Spring Harbor Laboratory (CSHL) are telling one another as they discuss a new finding they did not expect to make. They have discovered that hydrogen sulfide (H2S) the flammable, highly toxic gas that we usually associate with the smell of rotten eggs in landfills and sewers plays an important role in the regulation of a signaling pathway implicated in biological malfunctions linked to Alzheimer's and Parkinson's diseases, among others.

"H2S comes under the category of things that people think of as toxic and nasty, but which can actually be harnessed to serve a useful purpose," says CSHL Professor Nicholas K. Tonks, FRS, who led the research team. In fact, H2S, which is produced naturally in small quantities in various tissues, is a gasotransmitter, one of a family of gaseous signaling molecules that includes nitrous oxide (NO) and carbon monoxide (CO). Unlike growth factors, cytokines and hormones that act through receptors in the cell membrane, these gasotransmitters are able to permeate membranes and enter freely the interior of living cells.

Tonks and colleagues were intrigued by reports in the scientific literature suggesting that H2S was produced as part of the cell's response to what is called ER stress. The ER is the cellular organ called the endoplasmic reticulum. It is an extensive network of membranes spread throughout the cytosol, which is involved in protein synthesis and processing.

When the cell is placed under stress, specifically when newly formed proteins are being manufactured in the ER so rapidly that they do not fold properly, rendering them non-functional, the cell must make a decision either to slow down protein production to match its physiological requirements in the hope that proteins will begin to fold properly or, if that is not sufficient, to commit a form of suicid
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. MIT researchers discover an unexpected twist in cancer metabolism
2. Unexpectedly small effects of mutations in bacteria bring new perspectives
3. Youth adapt faster than seniors to unexpected events
4. Unexpected find opens up new front in effort to stop HIV
5. Revealing the wiring that allows us to adapt to the unexpected
6. An extra 5 years of life an unexpected benefit of osteoporosis treatment
7. Unexpected new mechanism behind rheumatoid arthritis
8. Mount Sinai researcher finds unexpected temperature sensation for a light detector
9. Metabolic protein plays unexpected role in tumor cell formation and growth
10. Defective signaling pathway sheds light on cystic fibrosis
11. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... , ... July 01, 2015 , ... Amada Senior Care, ... new office in the greater Phoenix area – their Mesa, Arizona location . ... senior care with their purchase of the rights to the area after years of ...
(Date:7/1/2015)... ... ... Who doesn’t want a life filled with thriving positivity and high-life satisfaction? Do ... life, and positive friendships and relationships? , Dr. Marsha W. Snyder explains how ... , With a focus on solving the epidemic of ill-being in the medical profession, ...
(Date:7/1/2015)... ... July 01, 2015 , ... Northbound Treatment Services ... of Referral Relations. , Emily originally entered the behavioral healthcare industry as ... implemented unique academic curriculum for clients to engage in their educational journey while ...
(Date:7/1/2015)... ... July 01, 2015 , ... AvePoint, ... announced the opening of a new operational office in Zurich, Switzerland. The new ... across all lines of business for organizations throughout the Swiss market. , ...
(Date:7/1/2015)... ... 2015 , ... Recent research has revealed that most adults lack confidence in ... to professionals. Starting the last Monday of June, Whiter Image Dental will ... discount on the customer’s first popular In-Office 2 Patient Kit. , ...
Breaking Medicine News(10 mins):Health News:Amada Senior Care Expands to Greater Phoenix Area 2Health News:Medical Doctor Explains The Healthy Effects of a Positive Outlook in New Book 2Health News:Northbound Treatment Services Welcomes Emily Orrick as Director of Referral Relations 2Health News:AvePoint Opens Office in Zurich to Meet Increasing Market Demand for Enterprise Collaboration Solutions in Switzerland 2Health News:AvePoint Opens Office in Zurich to Meet Increasing Market Demand for Enterprise Collaboration Solutions in Switzerland 3Health News:Whiter Image Dental Offers New Customers Half-Off Teeth Whitening Kit 2
... feet on Wii boards, report notes , WEDNESDAY, Feb. 3 ... gaming in 2006, more than just the ligaments and tendons ... a new report details foot injuries that have been incurred ... of games were introduced, patients typically presented with ligament injuries ...
... , WEDNESDAY, Feb. 3 (HealthDay News) -- Recent immigrants to ... suffer a stroke at a young age than long-term residents, ... identified 966,000 new immigrants to Ontario over a 12-year period ... lived in the province for at least five years. During ...
... ... partnership with the World Food Program (WFP), successfully distributed critically needed food supplies over ... , ... (Vocus) February 3, 2010 -- The global humanitarian organization Save the Children, in partnership ...
... , , Hope4MentalHealth.org Served Up Celebrities and Tweeted Up ... in Park City January 23-24 , ... made its debut in Park City, Utah as a sponsor ... during the 2010 Sundance Film Festival™ . A multi tiered event ...
... , ... this past season has been marked as the winningest in franchise history, ... who provided quarterback DREW BREES ( PURDUE ) ... list of "firsts" today.  The New Orleans Saints offensive line was the ...
... ... and Unstructured Outdoor Play, , ... Washington (Vocus) February 3, 2010 -- National Wildlife Federation (NWF), more than 200 health, ... make time outdoors a health priority for children. , , , , ,The new ...
Cached Medicine News:Health News:Wii Popularity Leads to New Kind of Gaming Injury 2Health News:Wii Popularity Leads to New Kind of Gaming Injury 3Health News:Immigrants at Lower Stroke Risk Than Long-Term Residents? 2Health News:Save the Children Supplies 30,000 Haitian Children and Families with Rice at Sites in Marissant and Tabarre, Will Continue for Two Weeks 2Health News:Save the Children Supplies 30,000 Haitian Children and Families with Rice at Sites in Marissant and Tabarre, Will Continue for Two Weeks 3Health News:Hope4MentalHealth.org Made Its Debut at Sundance 2Health News:Hope4MentalHealth.org Made Its Debut at Sundance 3Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 2Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 3Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 4Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 5Health News:Health, Conservation, Youth-Serving Groups To Surgeon General:,Make Outdoor Time A Health Priority , 2Health News:Health, Conservation, Youth-Serving Groups To Surgeon General:,Make Outdoor Time A Health Priority , 3Health News:Health, Conservation, Youth-Serving Groups To Surgeon General:,Make Outdoor Time A Health Priority , 4Health News:Health, Conservation, Youth-Serving Groups To Surgeon General:,Make Outdoor Time A Health Priority , 5
(Date:6/30/2015)... -- Today, UBM China, a wholly owned subsidiary of ... Exhibition Co., Ltd. to jointly run the Health Expo ... concurrently with CWMEE 2016. This cooperation ... MEDTEC China and DENTECH China, and fills its blank ... also another concrete cooperative project in Chengdu ...
(Date:6/30/2015)... 2015  July 4 th is this weekend, a ... spirit and people behind it. To help honor our current ... USA Medical Card, a leading provider of ... that empower independence for our disabled military veterans, police, firemen, ... afford their prescriptions. "Due to USA ...
(Date:6/30/2015)... N.C. , June 30, 2015  Marken, the ... to the life sciences industry, has been granted permission ... patient shipment of clinical drug product in Korea.  This ... South Korea to continue receiving their clinical ... System (MERS). The emergency was caused by ...
Breaking Medicine Technology:UBM Joins Chengdu Tianyi to Hold CWMEE 2016 2UBM Joins Chengdu Tianyi to Hold CWMEE 2016 3Hope For Heroes and USA Medical Card Make a Difference for Our Nation's Heroes 2Marken Delivers Direct To Patients During MERS Outbreak 2Marken Delivers Direct To Patients During MERS Outbreak 3
... - VASTox plc (AIM: VOX), a leading,UK biotechnology ... of £400,000 by the Welsh Development Agency,(”WDA”) under ... 12 months, will support the research and development,work ... the unique skills and expertise of its scientists,based ...
... 2007 /PRNewswire-USNewswire/ -- The,following statement may be attributed ... Medical Research (CAMR): , "In the face of ... the stroke of his veto pen deliberately to ... well as endanger,the future health and well being ...
Cached Medicine Technology:Vastox Awarded £400,000 Grant to Support R&D at,Carbohydrate Chemistry Facility 2Vastox Awarded £400,000 Grant to Support R&D at,Carbohydrate Chemistry Facility 3President Bush Ignores America's Plea for Support of Stem Cell,Research 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: