Navigation Links
Unexpected new mechanism behind rheumatoid arthritis
Date:2/7/2011

A team of researchers at the University of Gothenburg, Sweden, has identified an enzyme that protects against inflammation and joint destruction. Made when the researchers blocked production of the enzyme GGTase-I in transgenic mice, this unexpected discovery could lead to the identification of new mechanisms that control the development of inflammatory disorders, as well as new medicines.

The article has been published in the Journal of Clinical Investigation (JCI). GGTase-I is found in all cells but is particularly important for the function of so-called CAAX proteins in inflammatory cells. GGTase-I attaches a cholesterol-like fatty acid on the CAAX proteins.

Researchers previously believed that this fatty acid played an important role in activating the proteins and could contribute to the functioning of inflammatory cells. There are now medicines that include substances that suppress the activity of GGTase-I with the aim of stopping the CAAX proteins from working. These substances are already being clinically tested on cancer patients, and researchers have also wondered whether they could be used to alleviate inflammatory disorders such as rheumatoid arthritis.

However, treatment with substances that inhibit GGTase-I has often been non-specific, making it difficult for researchers to assess the real potential of GGTase-I as a drug target.

"We therefore developed genetic strategies in transgenic mice to switch off the gene that codes for GGTase-I," says PhD student Omar Khan who is heading up the study along with professor Martin Berg and co-worker docent/consultant Maria Bokarewa from the Institute of Medicine. "This allowed us to investigate whether a complete blockade of GGTase-I can inhibit the development of inflammatory disorders and whether there are any side-effects."

However, the results were quite the opposite of what the researchers were expecting. Instead of inhibiting inflammation, the deficiency of GG
'/>"/>

Contact: Omar Khan
omar.khan@wlab.gu.se
46-031-342-4723
University of Gothenburg
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. An extra 5 years of life an unexpected benefit of osteoporosis treatment
2. Revealing the wiring that allows us to adapt to the unexpected
3. Unexpected find opens up new front in effort to stop HIV
4. Youth adapt faster than seniors to unexpected events
5. Unexpectedly small effects of mutations in bacteria bring new perspectives
6. MIT researchers discover an unexpected twist in cancer metabolism
7. Princeton scientists discover mechanism involved in breast cancers spread to bone
8. UCLA researchers uncover new cell biological mechanism that regulates protein stability in cells
9. UCI researchers find novel memory-enhancing mechanism in brain
10. A new mechanism for reversible proteasome inhibition
11. NIH scientists identify mechanism responsible for spreading biofilm infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... leading Dartmouth researcher, working with The Melanoma Genetics Consortium, ... today in the Journal of the National Cancer ... of melanoma. , "For the first time, we have ... telomeres play a part in the risk of developing ... PhD, School of Medicine at the University of Leeds ...
(Date:9/19/2014)... News) -- U.S. military troops deployed to sunny climates ... to a new study. Many returning troops ... some cases, military personnel developed blisters on their skin ... size of their moles since being deployed overseas. ... skin cancer, the study authors noted. "The past ...
(Date:9/19/2014)... The U.S. Food and Drug Administration approved a new type ... a class of once-a-week injectable drugs that help manage blood ... "Trulicity is a new treatment option, which can be used ... sugar levels in the overall management of type 2 diabetes," ... Drug Evaluation II, said in an agency news release. ...
(Date:9/19/2014)... 2014 MetroMD, a leading anti-ageing clinic has ... of human health. This therapy has grown tremendously across USA ... more effective, safe and dependable. It has far reaching benefits ... to live a very healthy and active lifestyle even beyond ... therapy, a senior therapist at MetroMD said, “HGH or Human ...
(Date:9/19/2014)... - New research published today in the online journal ... reach 6,800 in West Africa by the end of ... , Arizona State University and Harvard University researchers ... rise in cases significantly increased in August in Liberia ... was put in place, indicating that the mass quarantine ...
Breaking Medicine News(10 mins):Health News:Melanoma risk found to have genetic determinant 2Health News:Some U.S. Troops May Face Greater Skin Cancer Risk 2Health News:FDA Approves Another Weekly Injectable Drug for Type 2 Diabetes 2Health News:MetroMD Announces Better HGH Therapy - the ‘God Particle’ of Human Health 2Health News:Research predicts possible 6,800 new Ebola cases this month 2
... April 2010 - Elsevier, the world-leading publisher of ... proudly announces the release of a brand-new single ... mitral valve disease by the internationally renowned cardiac ... will launch at the 90th Annual Meeting of ...
... ... and printing products, today announced it is ready for immediate shipping of thousands of ... through customer service or instantly online from the company’s award winning web site My1Stop.com. ... Ft. Scott, ...
... ... money with FatWallet’s expert selection of deals for Mother’s Day. Experienced experts research the ... and seasonal categories such as laptops, HDTVs, Father’s Day and graduation. , ... (PRWEB) April 26, 2010 -- ...
... ... Documentation by Integrating Electronic Medical Forms Generated During the Pre-operative Process into Core ... ... important new level of clinical integration designed to provide immediate access to patient ...
... ... area residents safe and effective cosmetic and aesthetic treatments. Advanced Aesthetics utilizes top ... ... The art of aesthetics is continually changing. As technology progresses, innovative treatments replace ...
... that factors known to increase the risk of breast cancer ... Published early online in Cancer , a peer-reviewed journal ... is needed to evaluate how breast cancer risk factors differ ... frequently in certain ethnic and racial groups, but the reasons ...
Cached Medicine News:Health News:Elsevier launches Carpentier's reconstructive valve surgery book 2Health News:My1Stop.com New Packaging Supplies Offering for Distribution Centers and Small Business Shipping 2Health News:Expert Approved: FatWallet Guides Mother's Day Shoppers to the Best Deals Online 2Health News:SourceMedical Provides Ambulatory Surgery Centers with New Levels of Document Integration for Easy Access to Patient Data 2Health News:SourceMedical Provides Ambulatory Surgery Centers with New Levels of Document Integration for Easy Access to Patient Data 3Health News:In Coeur d'Alene Idaho, Top Of The Line Aesthetic Treatments And Non-Invasive Laser Technology Can Be Found Only At Advanced Aesthetics 2Health News:In Coeur d'Alene Idaho, Top Of The Line Aesthetic Treatments And Non-Invasive Laser Technology Can Be Found Only At Advanced Aesthetics 3Health News:Breast cancer risk factors differ among races 2
(Date:9/19/2014)... Sept. 19, 2014 Today, iHealth Lab Inc. announced ... Ventures, Ltd. for its first institutional round of funding. ... iHealth,s global reach, accelerate growth and innovation, and invest ... the investment, Xiaomi Ventures will join iHealth,s board of ... infrastructure and ecommerce. "We are very pleased ...
(Date:9/19/2014)... , September 19, 2014 ... ) has announced the addition of the ... report to their offering.      ... have been broadly classified into wide categories ... used for the treatment of different gynecological ...
(Date:9/19/2014)... , Sept. 19, 2014  The board of ... declared a quarterly cash dividend of $0.42 per share.  ... 17, 2014 to stockholders of record at the close ... AbbVie AbbVie is a global, research-based biopharmaceutical company formed ... is to use its expertise, dedicated people and unique ...
Breaking Medicine Technology:iHealth Raises $25 Million to Fuel Growth and Global Market Share 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3
... Calif., April 14 Researchers at,the Barbara ... been studying,racial disparities related to cancer patients. ... (AACR) Annual Meeting, Karmanos researchers,Vitaly Balan, Ph.D., ... their abstract, Galectin-3 nsSNP rs4644 Foretells Human ...
... 14 Perrigo Company,(Nasdaq: PRGO ; ... final approval,from the U.S. Food and Drug ... Cetirizine Hydrochloride Oral Solution,(Allergy) and Children,s Cetirizine ... will be marketed under store brand labels ...
Cached Medicine Technology:Karmanos Researchers Study the Impact of Galectin-3 on Breast Cancer Disparity in Caucasian and Asian Women 2Karmanos Researchers Study the Impact of Galectin-3 on Breast Cancer Disparity in Caucasian and Asian Women 3Perrigo Announces Approval for Over-the-Counter Children's Cetirizine Oral Solution 2
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
... provide a broad selection of ... a wide variety of ophthalmic ... is packaged sterile, complete with ... switch in the "off " ...
... provide a broad selection of ... a wide variety of ophthalmic ... is packaged sterile, complete with ... switch in the "off " ...
Medicine Products: