Navigation Links
Unexpected find opens up new front in effort to stop HIV
Date:1/22/2011

HIV adapts in a surprising way to survive and thrive in its hiding spot within the human immune system, scientists have learned. While the finding helps explain why HIV remains such a formidable foe after three decades of research more than 30 million people worldwide are infected with HIV it also offers scientists a new, unexpected way to try to stop the virus.

The work by researchers at the University of Rochester Medical Center and Emory University was published Dec. 10 in the Journal of Biological Chemistry.

It's thanks largely to its ability to hide out in the body that HIV is able to survive for decades and ultimately win out against the body's relentless immune assault. One of the virus's favorite hiding spots is an immune cell called a macrophage, whose job is to chew up and destroy foreign invaders and cellular debris.

For more than 15 years, Baek Kim, Ph.D., has been fascinated by HIV's ability to take cover in a cell whose very job is to kill foreign cells. In the last couple of years Kim, professor of Microbiology and Immunology at the University of Rochester Medical Center, has teamed with Emory scientist Raymond F. Schinazi, Ph.D., D.Sc., director of the Laboratory of Biochemical Pharmacology at Emory's Center for AIDS Research, to test whether the virus is somehow able to sidestep its usual way of replicating when it's in the macrophage.

The pair found that when HIV faces a shortage of the molecular machinery needed to copy itself within the macrophage, the virus adapts by bypassing one of the molecules it usually uses and instead tapping another molecule that is available.

Normally, the virus uses dNTP (deoxynucleoside triphosphate, the building blocks for making the viral genetic machinery) to get the job done, but dNTP is hardly present in macrophages macrophages don't need it, since they don't replicate. But macrophages do have high levels of a closely related molecule called rNTP (ribonu
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MIT researchers discover an unexpected twist in cancer metabolism
2. Unexpectedly small effects of mutations in bacteria bring new perspectives
3. Youth adapt faster than seniors to unexpected events
4. Aegis of Bellevue Opens With Outstanding Attendance
5. St. Josephs Hospital-North Opens in North Tampa
6. Children's National Medical Center Opens Remaining Floors of Patient Tower
7. Leading U.S. Infertility Practice Opens Boston IVF The Maine Center in Portland, Helping Build Families in Maine
8. B2B Appointment Setting/Lead Generation Innovator Intelemark Opens New Office in Northeast
9. With Launch of a Rocket Composter, Northwest State Community College opens a new frontier in green technology in the US.
10. UniqueU Medical Weight Loss Program Opens Cincinnati Location
11. CDI College Opens a New Campus in Richmond
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... 31, 2015 , ... Ticket Down is a reliable source for authentic tickets ... Grant Park. The festival will end on Sunday, August 2nd. , ... annual Lollapalooza. This unique and unbelievably popular festival attracts the best in entertainment ...
(Date:7/31/2015)... ... ... The 2nd annual Ride to Fight On will start and end near the ... to Fight On is a cycling fundraiser that benefits the West Cancer Center, a ... University of Tennessee Health Science Center. A health and wellness festival featuring food, music, ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... Group, Inc. has re-branded their social media profiles to better connect with the ... consumers to communicate, find information, share insights and opinions. The Rally Insurance Group, ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to the article published July 27 on My ... was contained and extinguished by the city’s fire department before it caused major damage throughout ... time of the fire, and it was a fire alarm system that tipped off fire ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... educating both readers and potential patients alike on various plastic surgery procedures including, ... covered also include such popular dermatology procedures like Botox and fillers. , ...
Breaking Medicine News(10 mins):Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3Health News:Cosmetic Town: Now Providing Interactive And Vital Medical Knowledge 2
... hip is a growing problem that will continue to ... on risk factors for developing OA, but few have ... new study published in the December issue of Arthritis ... hip pain to determine their disease progression and to ...
... with the United States, Food and Drug Administration (FDA) ... the treatment of metastatic adenocarcinoma of the ... upper gastrointestinal tract, MONTREAL, ... will compare SP1049C plus Best Supportive Care (BSC),versus BSC alone for ...
... YORK (Nov. 29, 2007) -- There ... individuals in the U.S. diagnosed with chronic Immune ... reduces the number of platelets in their blood ... hemorrhages. Now, the results of an international multicenter ...
... today that life,sDHA(TM), its patented, vegetarian form of ... heart health, is now,available in three new products ... schnitzel, and cordon bleu, and will all,contain 40 ... Based in The,Netherlands, Dalco Foods provides food products ...
... , , WEDNESDAY, Nov. 28 (HealthDay News) -- The number of ... since the 1980s, and that means an increased risk of ... of radiation, a new report contends. , Today, more than ... United States, compared with 3 million in 1980. A CT ...
... African-American men face an observable disadvantage versus Caucasian ... Not only is prostate cancer detected later in African ... treat. , Findings on the social and ... today at the American Association for Cancer Research conference ...
Cached Medicine News:Health News:Identifying patients at high risk for total hip replacement 2Health News:Supratek Pharma Inc. announced today that under the Special Protocol 2Health News:Eltrombopag studied in Idiopathic Thrombocytopenic Purpura 2Health News:Martek's life'sDHA(TM) Featured in Dalco Foods Wellness Line Meat Products 2Health News:Martek's life'sDHA(TM) Featured in Dalco Foods Wellness Line Meat Products 3Health News:Rise in CT Scans Poses Cancer Risk 2Health News:Rise in CT Scans Poses Cancer Risk 3Health News:Genetic and behavioral differences add to prostate cancer disparities 2Health News:Genetic and behavioral differences add to prostate cancer disparities 3Health News:Genetic and behavioral differences add to prostate cancer disparities 4Health News:Genetic and behavioral differences add to prostate cancer disparities 5
(Date:7/31/2015)... July 31, 2015  Semler Scientific, Inc. (Nasdaq: ... services to healthcare insurers and physician groups, today reported ... 2015. "In the second quarter of ... revenue growth of 54%, quarter over quarter revenue growth ... installed base of FloChec® units of 18%," said Doug ...
(Date:7/31/2015)... 2015  Xencor, Inc. (NASDAQ: XNCR ), a ... treatment of autoimmune diseases, asthma and allergic diseases, and ... Hata to its board of directors. ... development is a tremendous asset to our board," said ... officer of Xencor. "Xencor faces a range of opportunities ...
(Date:7/31/2015)... HYDERABAD, India , July 31, 2015 /PRNewswire/ ... Billing and CRM solutions for video, data and cloud ... (PoC) with a leading pharma giant for Internet ... managing different IoT applications offered on subscription model. ... Pharma giant is striving for business ...
Breaking Medicine Technology:Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2
... CITY, Calif. and TORTONA, Italy, July 28, 2011 ... a global technology and engineering Company wholly-owned by Italy,s ... broad collaboration to develop and produce sustainable detergent alcohols ... includes development of second generation detergent alcohols from cellulosic ...
... Pa., July 28, 2011 McNeil Consumer ... for new dosing instructions lowering the maximum daily dose ... U.S. from 8 pills per day (4,000 mg) to ... designed to help encourage appropriate acetaminophen use and reduce ...
Cached Medicine Technology:Codexis and Chemtex to Collaborate on Sustainable Detergent Alcohols for the Household Products Market 2Codexis and Chemtex to Collaborate on Sustainable Detergent Alcohols for the Household Products Market 3Codexis and Chemtex to Collaborate on Sustainable Detergent Alcohols for the Household Products Market 4McNeil Consumer Healthcare Announces Plans for New Dosing Instructions for TYLENOL® Products 2McNeil Consumer Healthcare Announces Plans for New Dosing Instructions for TYLENOL® Products 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: