Navigation Links
Unexpected discovery opens up new opportunities for targeting cancer
Date:1/10/2012

Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding.

Professor Schwabe and his colleagues, Drs Watson, Fairall and Santos, have published their research this week in leading science magazine Nature detailing a new understanding of how transcriptional repression complexes work. Their work, which is based around determining atomic resolution structures of medically important bio-molecular complexes, has been ongoing for six years, and is currently funded through a 1.4 million grant from The Wellcome Trust.

Transcriptional regulatory complexes play an important role in the regulation of development, differentiation, cancer and homeostasis. Transcription is the process of creating a complementary RNA copy of a sequence of DNA and is the first step in the process of gene expression.

Professor John Schwabe, of the University of Leicester's Department of Biochemistry, said: "We have discovered a completely new and unexpected link between inositol phosphate signalling (in this case IP4) and the regulation of histone deacetylase enzymes and hence transcriptional repression or gene silencing.

"In simple terms, we have shown that IP4 acts as a natural signalling molecule to regulate histone deacetylase enzymes which play a key role in regulating gene expression. Apart from the considerable intellectual importance of understanding how transcription is regulated, repression complexes are important therapeutic targets for a number of cancers including several types of leukaemia.

"Our research identifies several new means to potentially target histone deacetylase enzymes therapeutically: either by using drugs to prevent IP4 binding to the enzyme or by interfering with the pathway through which the body makes IP4. Thus this work opens up a whole new area of research with potential for new drugs and a new approach to targeting histone deacetylase enzymes."

Professor Schwabe said that this research is not only an exciting breakthrough in the field, but is also a technological feat relying on both the excellent research facilities in Leicester and the microfocus X-ray source at the Diamond Light Source in Oxfordshire.


'/>"/>

Contact: John Schwabe
js336@le.ac.uk
44-116-229-7038
University of Leicester
Source:Eurekalert  

Related medicine news :

1. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
2. Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding
3. Metabolic protein plays unexpected role in tumor cell formation and growth
4. Mount Sinai researcher finds unexpected temperature sensation for a light detector
5. Unexpected new mechanism behind rheumatoid arthritis
6. An extra 5 years of life an unexpected benefit of osteoporosis treatment
7. Revealing the wiring that allows us to adapt to the unexpected
8. Unexpected find opens up new front in effort to stop HIV
9. Youth adapt faster than seniors to unexpected events
10. Unexpectedly small effects of mutations in bacteria bring new perspectives
11. MIT researchers discover an unexpected twist in cancer metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unexpected discovery opens up new opportunities for targeting cancer
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital ... area economy by obtaining investment capital for emerging technology companies. SCP has ... have already resulted in more than a million dollars of capital investment for ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Finally, a ... after venous procedures, dermaka cream can be incorporated into the post-surgical treatment plans of ... surgical procedures. , dermaka cream is very effective for bruising and causes a ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... , June 23, 2016 Revolutionary ... Oticon , industry leaders in advanced audiology ... of Oticon Opn ™, the world,s first internet ... possibilities for IoT devices.      (Photo: ... introduces a number of ,world firsts,: , ...
Breaking Medicine Technology: