Navigation Links
Unexpected discovery opens up new opportunities for targeting cancer
Date:1/10/2012

Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding.

Professor Schwabe and his colleagues, Drs Watson, Fairall and Santos, have published their research this week in leading science magazine Nature detailing a new understanding of how transcriptional repression complexes work. Their work, which is based around determining atomic resolution structures of medically important bio-molecular complexes, has been ongoing for six years, and is currently funded through a 1.4 million grant from The Wellcome Trust.

Transcriptional regulatory complexes play an important role in the regulation of development, differentiation, cancer and homeostasis. Transcription is the process of creating a complementary RNA copy of a sequence of DNA and is the first step in the process of gene expression.

Professor John Schwabe, of the University of Leicester's Department of Biochemistry, said: "We have discovered a completely new and unexpected link between inositol phosphate signalling (in this case IP4) and the regulation of histone deacetylase enzymes and hence transcriptional repression or gene silencing.

"In simple terms, we have shown that IP4 acts as a natural signalling molecule to regulate histone deacetylase enzymes which play a key role in regulating gene expression. Apart from the considerable intellectual importance of understanding how transcription is regulated, repression complexes are important therapeutic targets for a number of cancers including several types of leukaemia.

"Our research identifies several new means to potentially target histone deacetylase enzymes therapeutically: either by using drugs to prevent IP4 binding to the enzyme or by interfering with the pathway through which the body makes IP4. Thus this work opens up a whole new area of research with potential for new drugs and a new approach to targeting histone deacetylase enzymes."

Professor Schwabe said that this research is not only an exciting breakthrough in the field, but is also a technological feat relying on both the excellent research facilities in Leicester and the microfocus X-ray source at the Diamond Light Source in Oxfordshire.


'/>"/>

Contact: John Schwabe
js336@le.ac.uk
44-116-229-7038
University of Leicester
Source:Eurekalert  

Related medicine news :

1. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
2. Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding
3. Metabolic protein plays unexpected role in tumor cell formation and growth
4. Mount Sinai researcher finds unexpected temperature sensation for a light detector
5. Unexpected new mechanism behind rheumatoid arthritis
6. An extra 5 years of life an unexpected benefit of osteoporosis treatment
7. Revealing the wiring that allows us to adapt to the unexpected
8. Unexpected find opens up new front in effort to stop HIV
9. Youth adapt faster than seniors to unexpected events
10. Unexpectedly small effects of mutations in bacteria bring new perspectives
11. MIT researchers discover an unexpected twist in cancer metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unexpected discovery opens up new opportunities for targeting cancer
(Date:4/22/2017)... , ... April 22, 2017 ... ... of Eastern Pennsylvania has named PROSHRED® Security of Philadelphia its “Woman-Owned ... PROSHRED® Philadelphia specializes in providing information destruction , recycling, and ...
(Date:4/21/2017)... ... April 21, 2017 , ... An April 10 article ... of ancient teeth, which reveal a great deal about prehistoric ice-age dental practitioners and ... may have been used to remove decayed dental matter, and that teeth were then ...
(Date:4/21/2017)... ... April 21, 2017 , ... Chicago plastic surgeon, Dr. Anil R. Shah, ... is a benign bony lump located on the forehead usually attributed to a facial ... sight and pain. Dr. Shah has discovered an approach that is minimally invasive. He ...
(Date:4/21/2017)... ... 2017 , ... Dudnyk has announced the launch of its new brand identity, ... potential of specialty and orphan brands can only be achieved when the needs and ... Effect is at the heart of a true partnership between our agency and our ...
(Date:4/21/2017)... Hong Kong (PRWEB) , ... April 21, 2017 , ... ... Printing (U3DP), the first 3D printing facility among higher education institutions in Hong Kong ... 3D printing, in terms of the range and quantity of facilities in Hong Kong. ...
Breaking Medicine News(10 mins):
(Date:4/21/2017)... Halo Labs announces the launch of a ... called the Horizon at PEGS 2017 in ... analyzes sub visible particulate matter in biopharmaceutical samples to ... early as candidate selection and pre-formulation. Halo ... organization Elion Labs for system validation. "We ...
(Date:4/20/2017)... , April 20, 2017  Cogentix Medical, ... focused on providing the Urology, Uro/Gyn and Gynecology ... that Ash Keswani has joined the Company as ... this newly created position, Mr. Keswani will report ... CEO. "Our organization is delighted that ...
(Date:4/20/2017)... , April 20, 2017  Vivify Health, the ... devices, has been awarded a very significant patent for ... EMRs to continual care via digital health.  This landmark ... intellectual property and further secures Vivify,s position as the ... in 2009, was the first company to apply consumer ...
Breaking Medicine Technology: