Navigation Links
Unexpected discovery opens up new opportunities for targeting cancer
Date:1/10/2012

Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding.

Professor Schwabe and his colleagues, Drs Watson, Fairall and Santos, have published their research this week in leading science magazine Nature detailing a new understanding of how transcriptional repression complexes work. Their work, which is based around determining atomic resolution structures of medically important bio-molecular complexes, has been ongoing for six years, and is currently funded through a 1.4 million grant from The Wellcome Trust.

Transcriptional regulatory complexes play an important role in the regulation of development, differentiation, cancer and homeostasis. Transcription is the process of creating a complementary RNA copy of a sequence of DNA and is the first step in the process of gene expression.

Professor John Schwabe, of the University of Leicester's Department of Biochemistry, said: "We have discovered a completely new and unexpected link between inositol phosphate signalling (in this case IP4) and the regulation of histone deacetylase enzymes and hence transcriptional repression or gene silencing.

"In simple terms, we have shown that IP4 acts as a natural signalling molecule to regulate histone deacetylase enzymes which play a key role in regulating gene expression. Apart from the considerable intellectual importance of understanding how transcription is regulated, repression complexes are important therapeutic targets for a number of cancers including several types of leukaemia.

"Our research identifies several new means to potentially target histone deacetylase enzymes therapeutically: either by using drugs to prevent IP4 binding to the enzyme or by interfering with the pathway through which the body makes IP4. Thus this work opens up a whole new area of research with potential for new drugs and a new approach to targeting histone deacetylase enzymes."

Professor Schwabe said that this research is not only an exciting breakthrough in the field, but is also a technological feat relying on both the excellent research facilities in Leicester and the microfocus X-ray source at the Diamond Light Source in Oxfordshire.


'/>"/>

Contact: John Schwabe
js336@le.ac.uk
44-116-229-7038
University of Leicester
Source:Eurekalert  

Related medicine news :

1. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
2. Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding
3. Metabolic protein plays unexpected role in tumor cell formation and growth
4. Mount Sinai researcher finds unexpected temperature sensation for a light detector
5. Unexpected new mechanism behind rheumatoid arthritis
6. An extra 5 years of life an unexpected benefit of osteoporosis treatment
7. Revealing the wiring that allows us to adapt to the unexpected
8. Unexpected find opens up new front in effort to stop HIV
9. Youth adapt faster than seniors to unexpected events
10. Unexpectedly small effects of mutations in bacteria bring new perspectives
11. MIT researchers discover an unexpected twist in cancer metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unexpected discovery opens up new opportunities for targeting cancer
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Grove Investment Group (TGIG), has initiated cultivation and processing operations at its production ... and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
Breaking Medicine Technology: