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Undiagnosed OSA patients have altered cardiovascular responses during exercise recovery
Date:1/1/2008

WESTCHESTER, Ill. A study published in the January 1 issue of the journal SLEEP finds that people with untreated obstructive sleep apnea (OSA) have altered cardiovascular responses during recovery from maximal exercise. These results suggest an imbalance in the autonomic control of heart rate during recovery, and may be an early clinical sign of the progression of OSA.

The study, authored by Trent A. Hargens, PhD, of Virginia Tech, focused on 44 individuals: 14 overweight with OSA (OSA), 16 overweight without OSA (No-OSA) and 14 normal weight without OSA (Control). All were between the ages of 18 and 26. The subjects performed maximal ramping exercise testing on a cycle ergometer with five minutes of active recovery. Exercise measurements included heart rate, blood pressure, respiratory exchange ratio and oxygen consumption.

According to the results, in OSA patients, heart rate recovery was significantly weakened compared to the No-OSA and control groups throughout recovery. No differences were noted in the heart rate or blood pressure response to exercise in any group.

We believe our study is the first study to show blunted post-exercise heart rate recovery in young apparently healthy young men who have latent obstructive sleep apnea. Mechanistic studies by other investigators suggest that this response is a function of impaired vagal reactivation following vigorous exercise which is a marker specific to the autonomic dysfunction of sleep apnea, said William G. Herbert, PhD, a co-author of the study. Given these results were observed in young men, follow-up confirmation with large cohorts may support use of this marker for identifying men at early risk of sleep apnea and for monitoring therapy in those already being treated for this common but under-diagnosed disorder.

OSA is a sleep-related breathing disorder that causes your body to stop breathing during sleep. OSA occurs when the tissue in the back of the throat c
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Contact: Jim Arcuri
jarcuri@aasmnet.org
708-492-0930
American Academy of Sleep Medicine
Source:Eurekalert

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