Navigation Links
Underwater sponges and worms may hold key to cure for malaria
Date:6/28/2010

Healing powers for one of the world's deadliest diseases may lie within sponges, sea worms and other underwater creatures.

University of Central Florida scientist Debopam Chakrabarti is analyzing more than 2,500 samples from marine organisms collected off deep sea near Florida's coast. Some of them could hold the key to developing drugs to fight malaria, a mosquito-borne illness that kills more than 1 million people worldwide annually. Chakrabarti is pursuing this study with Amy Wright of Harbor Branch Oceanographic Institute, Fort Pierce, whose team has collected these samples from a depth up to 3000 feet.

Chakrabarti is excited about the early promising results preliminary tests identified about 300 samples that can kill malaria parasites. He's also concerned, however, that the Gulf of Mexico oil spill may wipe out species that could hold healing properties for many deadly diseases.

"There is a very good possibility that the answers to cancers, malaria and other diseases may be found in the ocean," he said. "Why am I so optimistic? Just consider that the oceans cover 70 percent of the planet. Among 36 of the phyla of life, 34 are found in marine environment whereas the land represents only 17 phyla, and we haven't even begun to explore the oceans' depths.

"But I'm worried. Who knows what we may be losing."

He watches the news while continuing his research in hopes of finding answers to malaria, a disease he's dedicated his life to combating. There is no FDA-approved vaccine for malaria, and people are becoming more resistant to the drugs available to treat it.

Chakrabarti and Wright landed a $500,000 grant from the National Institutes of Health and National Institute of Allergy and Infectious Diseases for their study.

So far, Chakrabarti and his two graduate students have conducted preliminary testing of more than 2,500 samples from the Harbor Branch collection. They conducted tests to evaluate growth inhibitory properties of these samples for malaria parasite growing inside human red blood cells in culture.

One active sample derived from a marine sponge contained the compound Nortopsentin. Because of this compound's initial promise, Chakrabarti said, he's already filed an application for patent protection.

Harbor Branch is one of only three organizations in the country that has the capability to collect deep-sea samples. It has submersible vehicles that dive 3,000 feet underwater to collect samples off Florida's coast. Wright directs the biomedical-marine research program at Harbor Branch.

Chakrabarti's approach of identifying new drugs from marine sources builds on prior research around the globe.

In May, the American Society of Clinical Oncology announced results from a Japanese study concluding that the drug eribulin, derived from sea sponges, was effective in helping patients fight breast, colon and urinary cancer. Scientists in Australia are diving into the Great Barrier Reef to explore the potential healing powers of marine creatures living there.

Locally, Gregory Roth, director of medical chemistry and exploratory pharmacology at the Sanford-Burnham Medical Research Institute is working with Harbor Branch on similar research. Sanford-Burnham is one of the UCF College of Medicine's partners at its new health sciences campus in Lake Nona.

Chakrabarti will continue analyzing samples, particularly the 300 already identified as promising, during the next year.

"If we can find two or three good molecules that can be easily synthesized in a lab and that can prevent malaria, I'd be very happy," he said.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Related medicine news :

1. Dangerous lung worms found in people who eat raw crayfish
2. Breakthrough by Danish scientists in preventing maternal malaria
3. UM School of Medicine scientists find new malaria vaccine is safe and protective in children
4. Malaria Parasite Infects Gorillas, Not Just Humans
5. Statement by Dr. Daniel Carucci, Vice President for Global Health for the United Nations Foundation, on Progress Shown in World Malaria Report 2009
6. ONE and Malaria No More Launch Malaria Griots
7. Scientists use cell phone records to predict spread of malaria
8. WHO World Malaria Report Shows Aid Efforts Are Working
9. UM School of Medicine scientists find new malaria vaccine is safe and promotes immune response in children
10. Mimotopes Awarded Major Peptide Supply Contract by the Queensland Institute of Medical Research in the Search for an Effective Malaria Vaccine
11. MARA Fights Malaria With WaveMaker and Amazon Web Services
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Underwater sponges and worms may hold key to cure for malaria
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
Breaking Medicine Technology: