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Understanding mental illness through gene-environment interactions
Date:3/17/2009

nges in the central nervous system, particularly in relation to learning and memory. Dr. Sweatt is also a talented artist and his painting adorns the cover of this issue of Biological Psychiatry. In another Review, Akbarian and Huang discuss mutations of genes that are involved in the regulation of histone lysine methylation, a type of epigenetic modification, that are associated with neurodevelopmental diseases, including mental retardation, autism and schizophrenia. They include novel approaches on examining how these mechanisms operate in a healthy or diseased brain. In the final epigenetics article of this issue, Monteggia and Kavalali examine the epigenetics of Rett syndrome, a neurodevelopmental disorder that causes mental retardation and autistic-like behavior, as it arises from mutations in a gene that is believed to alter synaptic transmission.

In all, these epigenetics papers provide fundamental new insights into the complex issues of gene-environment interactions and will aid future work that attempts to advance our understanding of mental illness.


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Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

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