Navigation Links
Understanding how neurons regulate metabolism in response to a high-fat diet
Date:8/1/2014

The brain plays a central role in regulating appetite and whole-body metabolism. A protein known as PPARγ is important in the brain's control of food intake and body weight, but the identity of the neurons regulating this process has been unclear. A new study in the Journal of Clinical Investigation demonstrates that PPARγ activity in a type of neuron known as pro-opiomelanocortin (POMC) neurons is critical in mediating the response to high-fat diet. Sabrina Diano and colleagues at Yale University School of Medicine found that mice lacking PPARγ specifically in POMC neurons gained less weight, were more active, and had improved glucose metabolism when fed a high-fat diet. Moreover, animals without PPARγ in POMC neurons did not gain weight when given PPARγ activators. The results of this study indicate that PPARγ expression in POMC neurons regulates whole-body energy balance. The findings also shed light on why PPARγ activators, which are used clinically to increase insulin sensitivity in patients with type 2 diabetes, have a side effect of promoting weight gain.


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Breakthrough in understanding of important blood protein
2. Increasing Molecular Level Understanding of Disease State & Metabolism Drives the Molecular Diagnostics Market, According to New Report by Global Industry Analysts, Inc.
3. Willem de Liefde, Author and Management Expert, Releases New Guide for Understanding Friends, Family, Co-Workers and Ourselves
4. Research brings us nearer to understanding how neuro cells turn cancerous
5. Immune cells role in intestinal movement may lead to better understanding of IBS
6. Scientists deepen genetic understanding of eosinophilic esophagitis
7. Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour
8. Pseudogenes may provide clearer understanding of biomarkers
9. Understanding the unique nature of childrens bodies and brains
10. Funding for better understanding of cancer-causing cell defect
11. Environmental factors as important as genes in understanding autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... ... that their Vice President of Franchise Development, Paula Turner Pizarro, was recently featured ... program, which features the insights of top business leaders from across the globe, ...
(Date:1/18/2017)... ... January 18, 2017 , ... At Hallmark Nameplate, their commitment to quality ... achieved certification to ISO 13485. This certification is another way they are making constant ... and services that they need. , The ISO 13485 Certification is a major accomplishment ...
(Date:1/18/2017)... ... January 18, 2017 , ... Michael J. Hennessy ... for its Center for Biosimilars, announced Michael J. Hennessy Associates, Inc. President Michael ... field of biosimilars through thought leader interaction in, live video and interactive digital ...
(Date:1/18/2017)... ... January 18, 2017 , ... During pregnancy, ... to enamel erosion, and those dental problems can increase the risk of pregnancy ... pregnant women are failing to get the dental care they need. Agoura Hills ...
(Date:1/17/2017)... ... ... Anesthesia Progress – Everyone wants less pain during dental surgery, ... each patient. Dentists have several general anesthesia alternatives and finding the right option can ... Dental College in Tokyo, Japan wanted to find out which anesthetic was the better ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... YORK , Jan. 17, 2017 EU5 ... GlobalData,s new report, "EU5 Glucose Monitoring Market Outlook ... Glucose Monitoring market. The report provides value, in millions ... (USD) within market segments - Blood Glucose Meters, Blood ... provides company shares and distribution shares data for each ...
(Date:1/17/2017)... 17, 2017 Paragon Bioservices received a multiple-award, ... services for a variety of National Institute ... product development activities. The IDIQ mechanism will allow ... task order awards up to $159 million. ... and process development of biopharmaceuticals, is one of ...
(Date:1/17/2017)... Pa. , Jan. 17, 2017  Pennsylvania ... today announced applications for medical marijuana growers/processors and ... Medical Marijuana Program website . Permit applications will ... 2017. "This is an important step ... who desperately need it," Secretary Murphy said. "We,ve ...
Breaking Medicine Technology: