Navigation Links
Understanding how neurons regulate metabolism in response to a high-fat diet
Date:8/1/2014

The brain plays a central role in regulating appetite and whole-body metabolism. A protein known as PPARγ is important in the brain's control of food intake and body weight, but the identity of the neurons regulating this process has been unclear. A new study in the Journal of Clinical Investigation demonstrates that PPARγ activity in a type of neuron known as pro-opiomelanocortin (POMC) neurons is critical in mediating the response to high-fat diet. Sabrina Diano and colleagues at Yale University School of Medicine found that mice lacking PPARγ specifically in POMC neurons gained less weight, were more active, and had improved glucose metabolism when fed a high-fat diet. Moreover, animals without PPARγ in POMC neurons did not gain weight when given PPARγ activators. The results of this study indicate that PPARγ expression in POMC neurons regulates whole-body energy balance. The findings also shed light on why PPARγ activators, which are used clinically to increase insulin sensitivity in patients with type 2 diabetes, have a side effect of promoting weight gain.


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Breakthrough in understanding of important blood protein
2. Increasing Molecular Level Understanding of Disease State & Metabolism Drives the Molecular Diagnostics Market, According to New Report by Global Industry Analysts, Inc.
3. Willem de Liefde, Author and Management Expert, Releases New Guide for Understanding Friends, Family, Co-Workers and Ourselves
4. Research brings us nearer to understanding how neuro cells turn cancerous
5. Immune cells role in intestinal movement may lead to better understanding of IBS
6. Scientists deepen genetic understanding of eosinophilic esophagitis
7. Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour
8. Pseudogenes may provide clearer understanding of biomarkers
9. Understanding the unique nature of childrens bodies and brains
10. Funding for better understanding of cancer-causing cell defect
11. Environmental factors as important as genes in understanding autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Clarify Health Solutions, ... raised $6.0 million in an initial round of funding. The round was led ... their caregivers can receive far better care through the application of the best ...
(Date:12/2/2016)... ... December 02, 2016 , ... Date aired: November ... Type 2 Diabetes: The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein , Sharon Kleyne, ... Water, Global Climate Change and Your Health radio program syndicated on Voice of ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... now offer a comprehensive in-house dental plan for all patients. Understanding that budget ... plan that gives patients a number of perks, including discounts on many valuable ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... mental health treatment has announced the opening of a new eating disorder treatment ... and intensive outpatient treatment for adults and adolescents, both males and females ages ...
(Date:11/30/2016)... Warrington, U.K. (PRWEB) , ... November 30, 2016 ... ... to address the tech functions and stylish design wanted by today’s consumers at ... , Cronovo Co-Founder Darin Philip says the new watch is “a game changer” ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , Dec 1, 2016 Research ... "Drug Delivery in Cancer - Technologies, Markets and Companies" ... , ... challenge in management of cancer The market value of ... Cancer market estimates from 2015-2025 are given according to organs involved ...
(Date:12/2/2016)... 2016 Around the corners of world, cancer ... habitable land present over earth. Cancer has become one ... a life time this is because of the increasing ... Given the steady increase in global cancer incidence with ... healthcare costs of treatment, there is increasing interest in ...
(Date:12/2/2016)... Dec. 2, 2016 Allergan plc (NYSE: ... information on its previously announced Accelerated Share Repurchase (ASR) Program. ... ... As previously announced, the Company entered into a ... the Company will repurchase $10 billion of its ordinary shares. ...
Breaking Medicine Technology: