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Undernourishment in pregnant, lactating females found key to next generation's disease
Date:6/13/2011

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Type 2 diabetes occurs when the body develops resistance to insulin, a hormone that regulates blood sugar. Although the body may initially compensate by secreting more insulin, eventually the pancreas cannot produce enough of the hormone to keep blood sugar from rising. In poorly controlled diabetes, elevated blood sugar severely damages the heart, blood vessels, eyes, kidneys and nerves. The consequences can be fatal and include heart disease, stroke, amputations, blindness and kidney failure.

Worldwide, diabetes is an escalating public health crisis. According to estimates from the World Health Organization (WHO), 366 million people will be diabetic by the 2030, up from 171 million in 2000. This is a 114 percent projected increase.

Formerly called "adult-onset diabetes," type 2 diabetes is seen increasingly in children at earlier and earlier ages. Excess body weight and physical inactivity are known causes, but Nathanielsz and his collaborators have long been interested in whether some individuals might be predisposed to diabetes from birth, or even earlier. Nathanielsz conducts research on this and similar topics through the Center for Pregnancy and Newborn Research in the UT Health Science Center's Department of Obstetrics and Gynecology.

The Study

For this study, to avoid the complication of influences from genes, researchers selected 18 female baboons similar in age and other observable characteristics and housed them with a fertile male baboon. All females became pregnant. From 30 days of gestation, 12 females were randomly assigned to be fed an appropriate diet for their weight. The other six received 70 percent of the chow given to control females on a weight-adjusted basis. The female baboons continued on their respective diets through delivery and the weaning of their offspring. Once the young baboons were weaned, they were fed normal diets.

Just before they reached puberty, the six young baboons
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Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Page: 1 2 3

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