Navigation Links
Under-twisted DNA origami delivers cancer drugs to tumors
Date:9/13/2012

Scientists at Karolinska Institutet in Sweden describe in a new study how so-called DNA origami can enhance the effect of certain cytostatics used in the treatment of cancer. With the aid of modern nanotechnology, scientists can target drugs direct to the tumour while leaving surrounding healthy tissue untouched.

The drug doxorubicin has long been used as a cytostatic (toxin) for cancer treatment but can cause serious adverse reactions such as myocardial disease and severe nausea. Because of this, scientists have been trying to find a means of delivering the drug to the morbid tumour cells without affecting healthy cells. A possible solution that many are pinning their hopes on is to use different types of nanoparticles as 'projectiles' primed with the active substance.

In the present study, which is published in the scientific journal ACS Nano, scientists at Karolinska Institutet show how DNA origami can be used as such a projectile (or carrier) of doxorubicin. DNA origami is a new technique for building nanostrucutres from DNA, the hereditary material found in the cell nucleus. Using this technique, researchers can produce highly complex nanostrucutres with surfaces to which complex patterns of proteins and many other molecules can easily be attached.

What the researchers did on this occasion was to package the doxorubicin in a DNA origami configuration designed in such a way that relaxed the degree of twist of the DNA double helix. This allowed the drug to be released more slowly and operate more effectively on the cancer cells at lower concentrations than is otherwise possible.

"When the DNA has a lower degree of twist, there's more room for the doxorubicin to become attached, which leads to its slower release," says group leader Dr Bjrn Hgberg. "Another advantage to using DNA origami is that we will quickly be able to develop the targeted protein system. This will enable us to deliver drugs in a way that is even more sparing of healthy cells."


'/>"/>
Contact: Press Officer Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. A Revolutionary Dietary Paradigm: New Cookbook Features A SOS-free (Salt, Oil, Sugar ) Diet That Delivers the Optimal Food Plan for Renewing Health
2. Adena Delivers Instant Health Information to Mobile Devices
3. Study Suggests Vaccine May Help Kids With Brain Cancer
4. New Stool Test Might Aid in Early Detection of Colon Cancer
5. Study reveals how cancer drug causes diabetic-like state
6. How a cancer drug leads to diabetes
7. You Survived Cancer: Now Pay Attention to Your Overall Health
8. New drug prevents spread of human prostate cancer cells
9. Eliminating the good cholesterol receptor may fight breast cancer
10. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
11. Experimental Chemo Combo for Colon Cancer Disappoints
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... 21, 2017 , ... Preora Diagnostics Inc. , a ... has received two prestigious recognitions that acknowledge the promise of its PWS Nanoctyology ... has been named a Top 100 Finalist for the 16th annual Chicago Innovation ...
(Date:9/21/2017)... ... 2017 , ... FlipBelt, the fitness brand that specializes in problem solving fitness ... market with the launch of their FlipBelt Crops. , The new fitness bottoms feature ... fingertips while at the gym, on the trail, or on-the-go. , “We always thought ...
(Date:9/21/2017)... ... September 21, 2017 , ... In the inaugural 30-minute podcast ... Professor of Education Gregory A. Smith examines student privacy issues with University of ... Schoolhouse Commercialism, Privacy, and the Failure of Policymaking . , Join Smith ...
(Date:9/20/2017)... Ashburn, Virginia (PRWEB) , ... September 20, 2017 ... ... Spartacote Flex Pure Clinical Plus Coating System for clients that rely on safety ... inhibit the growth of microorganisms. , Silver has been used for centuries for ...
(Date:9/20/2017)... ... , ... Doctors on Liens has added the medical group Bones and Spine ... a personal injury lien basis. Founded by Dr. Wayne Cheng, MD and Dr. Gordon ... with orthopedic injuries to patients in the Inland Empire. , Bones and Spines Surgery ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... , Pa. and KALAMAZOO, Mich. , Sept. ... Penn. , and OptiMed Specialty Pharmacy of ... partnership to offer a strategic hub service that expedites ... highly sought-after personal spirometer, Spiro PD 2.0, and wellness ... A spirometer is a medical device used to measure ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent review ... as the number one company for hearing aids, ranking it higher ... other brands. ... Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, state-of-the-art, ...
(Date:9/9/2017)... , Sept. 9, 2017  Eli Lilly and ... primary and secondary endpoint data for lasmiditan, an investigational, ... which demonstrated statistically significant improvements compared to placebo in ... highlighted today at the 18th Congress of the International ... "The data presented today demonstrate lasmiditan,s potential ...
Breaking Medicine Technology: