Navigation Links
Uncovering a flaw in drug testing for chronic anxiety disorder
Date:12/13/2012

Pre-clinical trials the stage at which medications or therapies are tested on animals like laboratory mice is a crucial part of drug development. It's only then that scientists can assess benefits and side effects before a drug is administered to patients.

Now, Prof. Ilan Golani of Tel Aviv University's Department of Zoology and Sagol School for Neuroscience and his fellow researchers Prof. Yoav Benjamini of TAU's Department of Statistics and Operations Research and the Sagol School of Neuroscience, and Dr. Ehud Fonio of the Weizmann Institute are questioning the animal models used for measuring chronic disorders such as Generalized Anxiety Disorder. Using a hundred-times longer experimental time-frame and comparing lab mice with wild mice, the researchers found that the lab mice used do not actually experience chronic anxiety.

Instead, the researchers found that the behavior exhibited by the mice in the first minutes of an experiment is only a temporary response to a new environment. With time, the mice revert back to their true temperaments lab mice have calm temperaments and wild mice are anxious. This discovery, which has been reported in the journals PLOS One and Nature Methods, could explain why most candidate drugs developed using this mouse model have poor therapeutic value in treating human brain disorders, says Prof. Golani.

Back to the wild

Because of their genetic similarity to humans, mice are the most commonly used lab animals. Countless hours and billions of dollars have been spent developing mouse models, whose genes can be engineered to mimic human diseases and disorders. And while many of these models have made invaluable contributions to the advancement of research into Parkinson's disease and various cancers, others have proven less effective.

A chronically anxious mouse model is crucial to test anti-anxiety therapies, says Prof. Golani. Currently, scientists use a spec
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Psychological testing may predict success in soccer
2. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
3. Proposed testosterone testing of some female olympians challenged by Stanford scientists
4. Guidelines Issued for When Docs Should Order Vascular Testing
5. Experts recommend men at risk for osteoporosis undergo bone density testing
6. Wednesday Is National HIV Testing Day
7. Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
8. HPV testing in HIV-positive women may help reduce frequent cervical cancer screening
9. What would happen without PSA testing?
10. Heterogeneous ER+ breast cancer models allow more accurate drug testing
11. By studying animal health, researchers find improved ways for developing, testing cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... July 28, 2014 Parker Waichman LLP, a ... to ensure that the heroes of 9/11 are never forgotten, ... announced an important deadline. According to a VCF message ... a covered cancer on or before October 12, 2012 must ... First responders and others who were allegedly injured by the ...
(Date:7/28/2014)... 28, 2014 The Brooke Jackman ... donated more than 200,000 books to children and families ... launch of Brooke’s Cooks, a new initiative designed to ... living among at-risk children and their families in the ... series of nutrition information workshops, cooking demonstrations and readings. ...
(Date:7/28/2014)... 28, 2014 Bariatric Eating, a leading ... that it will be introducing three additional flavors to ... summer. The additional flavors include: , Inspire Summer Melon ... , Inspire Pomegranate Razz Berry -­ Pomegranate, razz and ... vanilla cone , Bariatric Eating's Inspire protein powders ...
(Date:7/28/2014)... regions in the brain was able to arouse animals ... In the August issue of Anesthesiology , investigators ... with continuous doses of either agent would move, raise ... electrical stimulation delivered to the ventral tegmental area (VTA). ... substantia nigra, did not induce the animals to wake ...
(Date:7/28/2014)... York, New York (PRWEB) July 28, 2014 ... the long-acting birth control device caused some users to ... proper position in the uterus continue to mount in ... a new case list issued last month in New ... are pending in a multicounty litigation underway in Bergen ...
Breaking Medicine News(10 mins):Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2Health News:Stimulation of brain region restores consciousness to animals under general anesthesia 2Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 4
... The following fact sheet was released today by ... We Fail Partnership (AARP, Business Roundtable, National Federation of ... Divided We Fail, we urge you to act promptly ... Program (SCHIP). Our nation has a duty to give ...
... journal report:Study highlights:-- Cholesterol-lowering drug adherence drops with ... of going for 90 straight days without medication ... all co-payment group and twice as high in ... to the exempt group (received prescriptions without a ...
... Benzoyl Peroxide Wash to Utilize MICROSPONGE(R) Delivery SystemCARLSBAD, ... the launch of NeoBenz Micro Wash, ... with the MICROSPONGE (R) delivery system, for ... NeoBenz Micro Wash contains 7% benzoyl ...
... 29 Years of Experience with Complex Rehab MarketHOUSTON, Jan. ... almost 30 years of experience, has joined Alliance ... fastest growing accredited complex rehab companies. Kieschnik is an ... Technology Supplier (CRTS) in Houston, Texas, for ASM ( ...
... Association rapid access journal reportStudy highlights:, , ... determine the odds of having cardiovascular disease within 10 years may ... Most adults 50 years and younger have a low ... for heart disease. , Researchers ...
... urban areas , , WEDNESDAY, Jan. 14 (HealthDay News) -- ... are making a comeback in some urban areas, a new ... where infestations have grown in recent years, appear to have ... pyrethroid toxins, such as deltamethrin, commonly used against them, according ...
Cached Medicine News:Health News:Health Care For 11 Million Children 2Health News:Health Care For 11 Million Children 3Health News:Health Care For 11 Million Children 4Health News:Co-Payment Increases Result in Gaps in Veterans' Prescription Usage 2Health News:Co-Payment Increases Result in Gaps in Veterans' Prescription Usage 3Health News:Co-Payment Increases Result in Gaps in Veterans' Prescription Usage 4Health News:SkinMedica(R) Launches NeoBenz(R) Micro Wash for Acne 2Health News:SkinMedica(R) Launches NeoBenz(R) Micro Wash for Acne 3Health News:Veteran Rehab Specialist, Anne Kieschnik, Joins Fast-Growing Alliance Seating & Mobility In Texas 2Health News:Veteran Rehab Specialist, Anne Kieschnik, Joins Fast-Growing Alliance Seating & Mobility In Texas 3Health News:Half of Adults 50 and Younger With Low 10-Year Risk of CVD Have High Lifetime Risk 2Health News:Half of Adults 50 and Younger With Low 10-Year Risk of CVD Have High Lifetime Risk 3Health News:Bed Bugs, Nearly Eradicated, Make a Comeback 2
(Date:7/28/2014)... 2014  A prospective study conducted by the ... has validated the performance of VolparaDensity breast imaging ... volumetrically assessed breast density measurements to breast cancer ... Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), the article, "Automated measurement ... breast cancer risk assessment," was authored by ...
(Date:7/28/2014)... 28, 2014  TNI BioTech, Inc. (OTCQB: TNIB) ... on the development, marketing and distribution of opioid-related ... proxy materials with the Securities and Exchange Commission ... Shareholders to be held on Thursday, September 4, ... record date for determining those shareholders eligible to ...
(Date:7/28/2014)... (NYSE: RMD ), an innovator and pioneer ... and other chronic respiratory conditions, has won a permanent ... medical device manufacturer APEX Medical Corp. (APEX), prohibiting sales ... 220 masks.  The judgment was entered by the Regional ... appealable, and applies throughout Germany.  The ...
Breaking Medicine Technology:Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 2TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 3ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2
... and Only Approved Platelet Producer in Europe Represents ... Switzerland, Feb. 6 Amgen (Nasdaq: ... (EC) has granted marketing authorisation for Nplate(R) (romiplostim) ... (idiopathic) thrombocytopenic purpura (ITP) patients who are refractory ...
... CAMBRIDGE, Mass. and LONDON, Feb. 6 Idenix Pharmaceuticals, ... today announced the execution of a license agreement granting ... a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) in Phase ... treatment of HIV/AIDS. New NNRTIs are needed to ...
Cached Medicine Technology:Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) 2Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) 3Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) 4Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) 5Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) 6Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) 7Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) 8Idenix Pharmaceuticals and GlaxoSmithKline Sign Worldwide License Agreement for IDX899, a Novel NNRTI for the Treatment of HIV 2Idenix Pharmaceuticals and GlaxoSmithKline Sign Worldwide License Agreement for IDX899, a Novel NNRTI for the Treatment of HIV 3Idenix Pharmaceuticals and GlaxoSmithKline Sign Worldwide License Agreement for IDX899, a Novel NNRTI for the Treatment of HIV 4Idenix Pharmaceuticals and GlaxoSmithKline Sign Worldwide License Agreement for IDX899, a Novel NNRTI for the Treatment of HIV 5
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: