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Uncontrolled hypertension could bring increased risk for Alzheimer's disease
Date:3/18/2013

trokes and other cardiovascular complications.

Scientists cannot fully explain the neural mechanisms underlying the effect of hypertension and APOE ε4 on amyloid accumulation. But earlier research in animal models showed that chronic hypertension may enable easier penetration of the blood-brain barrier, resulting in more amyloid deposition.

The recent study is significant because it focuses on a group of healthy and cognitively normal middle-aged and older adults, which enables the examination of risk factors and amyloid burden before the development of preclinical dementia. The team plans for long-term longitudinal follow-up with participants to determine which proportion of the subjects eventually develop the disease.

The study's coauthors included Dr. Denise Park, director of the Dallas Lifespan Brain Study, and Dr. Kristen Kennedy and doctoral student Jennifer Rieck, all from The University of Texas at Dallas. The team also included Dr. Michael Devous and Dr. Ramon Diaz-Arrastia, scientists from UT Southwestern Medical Center and the Uniformed Services University of the Health Sciences. In addition to the National Institute on Aging, the Alzheimer's Association provided funds for the study. Avid Radiopharmaceutical provided doses of Amyvid that allowed the researchers to image the amyloid plaque with a PET scan.


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Contact: Emily Martinez
emily.martinez@utdallas.edu
972-345-0061
University of Texas at Dallas
Source:Eurekalert

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