Navigation Links
Umbilical cord protein analysis detects early onset infection
Date:1/29/2009

Yale School of Medicine researchers have identified proteins associated with early onset neonatal sepsis (EONS), a stealthy bacterial infection linked to premature birth, illness and death. Using protein analysis, the researchers have found the biomarkers that can provide key information on how EONS develops.

"The biomarkers we identified have diagnostic value for infection and inflammation," said Yale assistant professor Catalin Buhimschi, M.D., senior investigator on the study who presented the findings in an abstract at the Society for Maternal Fetal Medicine (SMFM) conference in San Diego, Calif. "We have identified changes that occur in the physiology of the fetus that is exposed to infection and inflammation in the amniotic fluid."

Premature births accounts for 75 percent of infant mortality and 50 percent of long-term handicaps, including blindness, deafness, bronchopulmonary dysplasia, developmental delay and cerebral palsy. The poor outcome is not entirely dependent on their gestational age at birth but rather on other processes such as early onset neonatal sepsis. EONS is extremely difficult to diagnose. At-risk pregnant women are currently treated with a dose of antibiotics before delivery. At birth, the babies are treated with yet another round of antibiotics. These antibiotics can mask the presence of EONS, leading to false negative bacterial culture test results and development of antibiotic resistance.

Buhimschi said that the Yale team's work might lead to earlier identification of EONS, so that only babies who need treatment receive antibiotics.

Buhimschi and his team analyzed protein in the cord blood of 155 preterm babies to identify which physiological pathways in the protein are activated in EONS. They used a technique called fluorescence 2-D differential gel electrophoresis (2D-DIGE) to create a map of the biomarkers in fetuses that have sepsis. They then observed how the proteins match in physiological pathways.

"We found that early onset neonatal sepsis is characterized by a variety of biomarkers that have different functions," said Buhimschi. "These biomarkers tell us how the fetus reacts to infection by giving a better map of a baby's physiology."

"We hope this research will lead to identifying babies who will develop EONS so that we can prevent its potentially devastating effects," Buhimschi added.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. Heart Valves Fashioned From Stem Cells in Umbilical Cord Blood
2. BioLife Solutions to Supply CryoStor(TM) to Cryobanks International as Standard Media for Preservation and Storage of Umbilical Cord Blood Stem Cells
3. Stem cells from umbilical cord used in the treatment of hepatic diseases
4. Umbilical cord blood cell transplants may help ALS patients
5. Cord Blood America Says Pennsylvania Joins New York and California in Informing Parents of the Advantages of Umbilical Cord Blood Storage
6. Health risks, benefits come with delayed umbilical cord clamping
7. Injection of human umbilical cord blood helps the aging brain
8. Cord Blood America Supports Trend From New York, California for States to Inform Parents of the Advantages of Umbilical Cord Blood Storage
9. Umbilical cord clamping should be delayed, says expert
10. UT Southwestern researchers identify protein that may explain healthy obesity
11. New Study: Protein in the Morning Helps Dieters Stay on Track and Keep Weight Off
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... today at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra ... authored journal articles published in Emergency Medicine Practice and Pediatric Emergency ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement ... Vice President of North American Capital Sales at HTG Molecular . ... in the commercialization of the HTG EdgeSeq system and associated reagents in North America. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
Breaking Medicine Technology: