Navigation Links
Umbilical cord blood cell transplants may help ALS patients
Date:6/24/2008

Tampa, FL (June 24, 2008) A study at the University of South Florida has shown that transplants of mononuclear human umbilical cord blood (MNChUCB) cells may help patients suffering from Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease. A disease in which the motor neurons in the spinal cord and brain degenerate, ALS leaves its victims with progressive muscle weakness, paralysis and, finally, respiratory failure three to five years after diagnosis.

In this study, USF researchers transplanted human umbilical cord blood (HUCB) cells into mouse models with ALS. Cells were transplanted at three different dose strength levels -- low, moderate and high -- to determine the degree to which dose levels of transplanted cells might delay disease symptom progression and increase lifespan. In results published today online at PloS ONE (Public Library of Science), researchers determined that the moderate-strength dose of HUCB cells was most effective in increasing lifespan and reducing disease progression.

"Our results demonstrate that treatment for ALS with an appropriate dose of MNC hUBC cells may provide a neuroprotective effect for motor neurons through active involvement of these cells in modulating the host immune inflammatory system response," said the study's lead author Svitlana Garbuzova-Davis, PhD, DSc, of the Center of Excellence for Aging and Brain Repair at USF.

According to the research team, modulating immune and inflammatory effectors with HUCB cells could have a protective effect on dying motor neurons. The team had previously shown that hUBC cell transplants reduced inflammation and provided neuroprotection in models of stroke and Alzheimer's disease.

"This preclinical study indicates that MNC hUBC cells may protect motor neurons by inhibiting an immune inflammatory response by decreasing pro-inflammatory cytokines, signaling proteins in the brain and spinal cord that play a role in immune response," Garbuzova-Davis and colleagues wrote. "Proinflammatory cytokines may be indirect mediators for glial cells' contribution to motoneuron death and the decrease in these cytokines might be due to a reduction of activated microglia, the cells that form active immune defense in the central nervous system."

The research team noted, however, that the mechanism underlying the beneficial effect of hUBC cells for repairing diseased motor neurons in ALS still needs more clarification.

Suggesting that 'more is not better,' it was the moderate, not the high, dose of hUBC cells that proved most effective. Researchers speculated that the high dose may have been less effective because it induced an immunological conflict within the mouse model.

"Future studies should look at multiple injections of smaller doses over time, in order to help translate this research to clinical trials," according to co-author Paul R. Sanberg, PhD, DSc, director of the Center.

"Developing an effective treatment for ALS is complicated by the diffuse nature of motor neuron death," concluded Garbuzova-Davis. "However, cell therapy may offer a promising new treatment."


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida Health
Source:Eurekalert

Related medicine news :

1. Cord Blood America Says Pennsylvania Joins New York and California in Informing Parents of the Advantages of Umbilical Cord Blood Storage
2. Health risks, benefits come with delayed umbilical cord clamping
3. Injection of human umbilical cord blood helps the aging brain
4. Cord Blood America Supports Trend From New York, California for States to Inform Parents of the Advantages of Umbilical Cord Blood Storage
5. Umbilical cord clamping should be delayed, says expert
6. Going Online to Draw the Line on High Blood Pressure
7. New blood clot guidelines for pregnant women
8. Local Blood Supply at Low Levels
9. Study in Circulation provides detail on how low blood flow promotes vascular disease
10. Symptom Screening Plus a Simple Blood Test Equals a 20 Percent Jump in Early Detection of Ovarian Cancer
11. Symptoms Plus Blood Test Boost Ovarian Cancer Detection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... (PRWEB) , ... ... ... For Immediate ... Polling Shows Young Women Seek Sex and Relationship Advice from ...
(Date:8/18/2017)... ... August 18, 2017 , ... Mediaplanet today announces the ... healthy lifestyles and highlighting the importance of proactive eye and ear health. The ... the latest innovations in hearing aid technology. , In this issue, the ...
(Date:8/18/2017)... WV (PRWEB) , ... August 18, 2017 , ... ... financial consulting services and asset protection assistance to communities in North-Central West Virginia, ... provide critical services to at-risk boys in the area. , The Chestnut Mountain ...
(Date:8/18/2017)... ... August 18, 2017 , ... Goss & Associates ... residential and commercial clients in the greater Houston region, is helping locally recognized ... the fight against cancer. , Founded by Tony and Amber Bender after losing ...
(Date:8/18/2017)... ... ... Overseer at The House of Yahweh in Abilene, Texas, has released a new publication this ... of the Savior whom the world calls “Mother Mary”. Yisrayl says when compared to what ... historical woman. , “The world bows, kisses the feet of, cries out to and ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017   Mostyn Law and Gulf Coast ... Houston, Texas . The Mostyn Law family has ... years. That is why Mostyn Law is partnering with ... to show its appreciation. Blood supplies are running low. ... short of hospital needs in August. That is why the blood ...
(Date:8/15/2017)... 15, 2017  AOTI Inc. announced today that its fully owned ... recently opened a New York City Office in Yonkers, ... unique Topical Wound Oxygen (TWO 2 ) homecare therapy. This new ... for Health Care (ACHC) under the company,s DMEPOS accreditation for Home/Durable ... Advanced ...
(Date:8/8/2017)... AVIV, Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: ... immunology, today reports its financial results for the second ... achievements during the second quarter 2017 and to date: ... multiple clinical development programs for the Company,s lead project, ... 3 pivotal study with BL-8040 as novel stem cell ...
Breaking Medicine Technology: