Navigation Links
Ultrasound plus proteomic blood analyses may help physicians diagnose early-stage ovarian cancer
Date:1/21/2010

Noninvasive contrast-enhanced ultrasound imaging, combined with proteomic analyses of blood samples may help physicians identify early-stage ovarian cancer and save the lives of many women, according to an article published in the February issue of the American Journal of Roentgenology. Proteomics is the study of proteins, particularly their structure and function.

Ovarian cancer is the fifth leading cause of cancer-related death. More than 21,500 women annually are diagnosed with the disease. Each year, nearly 15,000 women die from ovarian cancer. More than two-thirds of these patients (67 percent) are diagnosed at an advanced-stage. If early-stage ovarian cancer is detected, survival is greater than 90 percent (compared to 30 percent for advanced-stage disease).

"The fact that so many women are not diagnosed until their disease is advanced confirms the inadequacy of pelvic examinations and standard ultrasound in detecting early-stage ovarian cancer and the dire need for a validated screening method for the detection of early-stage disease," said David A. Fishman, MD, lead author of the article. "The ability to detect ovarian cancer by a simple blood test has long been the holy grail of screening tests. Although a single biomarker blood test would be ideal and simple, it is not possible at present," said Fishman.

The study of proteomics and new analytical techniques using mass spectrometry has led to the discovery of hundreds of unique proteins that may serve as biomarkers and aid in the detection of early-stage cancer. "This new discovery sheds light on the possibility that highly discriminatory proteins may be used for the detection of ovarian cancer. However it is necessary to verify any information found by proteomic analysis with an imaging technique," said Fishman.

Researchers at Mount Sinai School of Medicine and Vanderbilt University Medical Center have discovered that an inexpensive, noninvasive medical imaging technique called contrast-enhanced ultrasound may play a complementary role to confirming or refuting newly discovered biomarkers' ability to accurately detect early-stage ovarian cancer. "We also found that the contrast agents may significantly improve the diagnostic ability of ultrasound to identify early microvascular changes that are known to be associated with early-stage ovarian cancer," said Arthur C. Fleischer, MD, co-author of the article.

"Separately, proteomics and ultrasound are of limited value as early-detection tools," said Fleischer. "However in combination, we will likely be able to shift from an era of diagnosing advanced stage ovarian cancer to that of early-stage disease and, most important, save the lives of many women," he said.


'/>"/>

Contact: Heather Curry
hcurry@acr-arrs.org
703-390-9822
American College of Radiology / American Roentgen Ray Society
Source:Eurekalert

Related medicine news :

1. New acoustic absorber to improve physiotherapy ultrasound machines
2. Ultrasound plus mammography finds more cancers, but increases false positives
3. Good Imaging Now Comes in the Worlds Smallest Ultrasound Package
4. VIDEO from Medialink and Siemens: Worlds Smallest Ultrasound Package Launches in the U.S.
5. Aloka to Unveil New ProSound Diagnostic Ultrasound System at the 17th World Congress on Ultrasound in Obstetrics and Gynecology, 7th to 11th of October 2007 in Florence, Italy
6. Transcutaneous cervical esophageal ultrasound can not substitute for 24-h pH monitoring or manometry
7. Ultrasound-guided injections help ease chronic Achilles tendon pain
8. Ultrasound Beats Blood Test for Gauging Ovarian Cancers: Study
9. Through-Wave Ultrasound: Effective, Economical and Ideal for Breast Imaging, Biopsy
10. ZONARE Surpasses 1000th Worldwide z.one Ultrasound System Shipment
11. Ultrasound Treats Localized Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 2016 , ... An April Gallup survey found rising health care costs to ... Sun Health Senior Living (SHSL) may not share those same worries thanks to ... for the year, while holding the line on increasing their contributions, including premiums, deductibles ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership of Life Science ... the organization has earned its ISO 13485 certification, indicating the company’s quality control ... rules and policies associated with ISO quality standard 13485. , BSI Group ...
(Date:5/26/2016)... Texas (PRWEB) , ... May 26, 2016 , ... ... Friday, May 13 at Blackhorse Golf Club in Cypress. With the help of community ... non-profit that restores, empowers, and renews hope for wounded service members and their families ...
(Date:5/26/2016)... ... May 26, 2016 , ... The MIAMI Institute for Age Management and ... Adonis Maiquez MD, ABAARM. Dr. Adonis , Wellness Physician of the MIAMI Institute ... of the Institute for Functional Medicine. , He also heads up FITTLab, the comprehensive ...
(Date:5/26/2016)... ... ... Bunion Bootie , the manufacturer of the newest and best in ... customer demand over the Mother’s Day Weekend promotion. So much so, that they completely ... completely replenished its inventory levels, it hopes to continue its current sales pace, and ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... ReportsnReports.com adds "Chronic Cough ... provides an overview on therapeutic pipeline of Chronic ... therapeutics assessment by drug target, mechanism of action ... along with latest updates, and featured news and ... in the therapeutic development for Chronic Cough and ...
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
(Date:5/24/2016)... May 24, 2016 The ... world , s first dual therapy stent, ...   OrbusNeich, a global company specializing in ... portfolio to include products to treat peripheral artery disease. ... first entry devices for lower limb and arteriovenous (AV) ...
Breaking Medicine Technology: