Navigation Links
Ultrasound plus proteomic blood analyses may help physicians diagnose early-stage ovarian cancer
Date:1/21/2010

Noninvasive contrast-enhanced ultrasound imaging, combined with proteomic analyses of blood samples may help physicians identify early-stage ovarian cancer and save the lives of many women, according to an article published in the February issue of the American Journal of Roentgenology. Proteomics is the study of proteins, particularly their structure and function.

Ovarian cancer is the fifth leading cause of cancer-related death. More than 21,500 women annually are diagnosed with the disease. Each year, nearly 15,000 women die from ovarian cancer. More than two-thirds of these patients (67 percent) are diagnosed at an advanced-stage. If early-stage ovarian cancer is detected, survival is greater than 90 percent (compared to 30 percent for advanced-stage disease).

"The fact that so many women are not diagnosed until their disease is advanced confirms the inadequacy of pelvic examinations and standard ultrasound in detecting early-stage ovarian cancer and the dire need for a validated screening method for the detection of early-stage disease," said David A. Fishman, MD, lead author of the article. "The ability to detect ovarian cancer by a simple blood test has long been the holy grail of screening tests. Although a single biomarker blood test would be ideal and simple, it is not possible at present," said Fishman.

The study of proteomics and new analytical techniques using mass spectrometry has led to the discovery of hundreds of unique proteins that may serve as biomarkers and aid in the detection of early-stage cancer. "This new discovery sheds light on the possibility that highly discriminatory proteins may be used for the detection of ovarian cancer. However it is necessary to verify any information found by proteomic analysis with an imaging technique," said Fishman.

Researchers at Mount Sinai School of Medicine and Vanderbilt University Medical Center have discovered that an inexpensive, noninvasive medical imaging technique called contrast-enhanced ultrasound may play a complementary role to confirming or refuting newly discovered biomarkers' ability to accurately detect early-stage ovarian cancer. "We also found that the contrast agents may significantly improve the diagnostic ability of ultrasound to identify early microvascular changes that are known to be associated with early-stage ovarian cancer," said Arthur C. Fleischer, MD, co-author of the article.

"Separately, proteomics and ultrasound are of limited value as early-detection tools," said Fleischer. "However in combination, we will likely be able to shift from an era of diagnosing advanced stage ovarian cancer to that of early-stage disease and, most important, save the lives of many women," he said.


'/>"/>

Contact: Heather Curry
hcurry@acr-arrs.org
703-390-9822
American College of Radiology / American Roentgen Ray Society
Source:Eurekalert

Related medicine news :

1. New acoustic absorber to improve physiotherapy ultrasound machines
2. Ultrasound plus mammography finds more cancers, but increases false positives
3. Good Imaging Now Comes in the Worlds Smallest Ultrasound Package
4. VIDEO from Medialink and Siemens: Worlds Smallest Ultrasound Package Launches in the U.S.
5. Aloka to Unveil New ProSound Diagnostic Ultrasound System at the 17th World Congress on Ultrasound in Obstetrics and Gynecology, 7th to 11th of October 2007 in Florence, Italy
6. Transcutaneous cervical esophageal ultrasound can not substitute for 24-h pH monitoring or manometry
7. Ultrasound-guided injections help ease chronic Achilles tendon pain
8. Ultrasound Beats Blood Test for Gauging Ovarian Cancers: Study
9. Through-Wave Ultrasound: Effective, Economical and Ideal for Breast Imaging, Biopsy
10. ZONARE Surpasses 1000th Worldwide z.one Ultrasound System Shipment
11. Ultrasound Treats Localized Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Looking for a last-minute Valentine’s ... the tips of your toes. Foot massage, whether administered by a professional masseuse or ... relaxation. The American Board of Multiple Specialties in Podiatry (ABMSP) has taken ...
(Date:2/5/2016)... Rafael, CA (PRWEB) , ... February 05, 2016 , ... ... with ChildLight Yoga Studio in Dover, NH to direct high-performance kids yoga training. ChildLight ... New Hampshire’s seacoast, just one hour from Boston. , ChildLight Yoga Studio founder Lisa ...
(Date:2/5/2016)... ... 05, 2016 , ... Give To Cure today announced that it ... to Give To Cure’s campaign that is crowdfunding clinical trials to help find cures ... payments through a smart device. In 2015 alone, Venmo processed $7.5 billion in transactions ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Dr. Justin ... announce their 2nd Annual No Cost Dental Day to individuals in need. The event ... purpose of this No Cost Dental Day is to provide dental care to community ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... In sleep, ... form as a dream. A hallmark feature of patients with eating disorders is significant ... The eating disorder behaviors and obsessions are regarded as maladaptive means for coping with ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... filed in the United States District Court for the District ... class (the "Class") consisting of all persons or entities who ... "Company") (NASDAQ: INSY ) from March 3, 2015 through ... and certain of its officers with violations of the Securities ...
(Date:2/4/2016)... 4, 2016  Montoya Love is recognized by Continental ... of Pharmaceuticals. Montoya is the Regulatory Systems Operations Manager ... Manufacturing and selling a broad ... provides healthcare institutions, clinical laboratories and life science ... across the globe. ...
(Date:2/4/2016)... 2016 Frontier Pharma: Chronic Obstructive Pulmonary ... Chronic Obstructive Pulmonary Disease (COPD) ... of the airways and lungs. Persistent breathing difficulties ... disease one of the leading causes of morbidity ... world. COPD is linked to cumulative exposure to ...
Breaking Medicine Technology: