Navigation Links
Ultrasound plus mammography finds more cancers, but increases false positives

CHAPEL HILL Adding ultrasound to mammography finds more cancers than mammography alone, but also substantially increases the number of false positives, according to first-year results from a three-year study of the two tests.

At this point, its not clear whether the benefit provided by ultrasound outweighs the additional expense, stress and inconvenience caused by the false positives, said study co-author Etta Pisano, M.D., vice dean for academic affairs in the University of North Carolina at Chapel Hill School of Medicine, Kenan professor of radiology and biomedical engineering and director of the UNC Biomedical Research Imaging Center.

We know that ultrasound does find more cancers. The question is, does it find enough more cancers to make it worthwhile" she said.

The results were presented today (Sept. 28) at the American College of Radiologys fall meeting in Washington, D.C.

The studys principal investigator and lead author is Wendie A. Berg, M.D., Ph.D., of American Radiology Services, located at Johns Hopkins at Greenspring Station in Lutherville, Md. UNC Hospitals is one of the primary study sites, with an enrollment of 198 women (7.5 percent of the study participants).

In the study, 2,637 women at high risk for breast cancer received both mammography and ultrasound exams. The tests were performed by physicians who received special training in breast ultrasound screening. Among the participants, 41 breast cancers were found in 40 women (one had cancer in both breasts) by one or both of the tests. Twelve of the cancers were found by ultrasound alone.

The addition of ultrasound resulted in 136 (5.2 percent) women having biopsies due to suspicion of cancer. Of these women, 14 or 8.5 percent were diagnosed with breast cancer.

Based on these results, the authors concluded that adding ultrasound to mammography will find approximately an additional one to seven cancers per 1,000 high-risk women who had not previously been screened by ultrasound, but will also substantially increase the number of false positives.

We had hoped to see a bigger effect of ultrasound compared to mammography, Pisano said. But I think these results show its a mixed picture at this point.

Pisano said that the study will add magnetic resonance imaging (MRI) exams in its third year, allowing researchers to directly compare the effectiveness of MRI, ultrasound and mammography.

At that point we will have good data on the cost-effectiveness of MRI versus ultrasound on top of mammography, she said. That will be the definitive analysis.


Contact: Stephanie Crayton
University of North Carolina at Chapel Hill

Related medicine news :

1. Ultrasound helps stroke treatment
2. Ultrasound test may detect heart condition early
3. Adding contrast improves ultrasounds ability to detect prostate cancer
4. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
5. The Safety Of Prenatal Ultrasounds Questioned
6. Stanford Medical Center Implements The First Virtual Cardiac Ultrasound
7. Ultrasounds To Detect Changes In Heart Motions
8. Ultrasound may mean end to classic stethoscope
9. Optical Imaging Added To Ultrasound To Improve Imaging Of Breast Cancer
10. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
11. Fetal Development Face The Threat By Frequent Ultrasounds
Post Your Comments:
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. ... ... ... ... Astellas is a ...
Breaking Medicine Technology: