Navigation Links
UW study: Sleep apnea associated with higher mortality from cancer
Date:5/20/2012

Madison, Wis. and San Francisco Sleep-disordered breathing (SDB), commonly known as sleep apnea, is associated with an increased risk of cancer mortality, according to a new study.

While previous studies have associated SDB with increased risks of hypertension, cardiovascular disease, depression, and early death, this is the first human study to link apnea with higher rate of cancer mortality. Lead author Dr. F. Javier Nieto, chair of the department of population health sciences at the UW School of Medicine and Public Health, says the study showed a nearly five times higher incidence of cancer deaths in patients with severe SDB compared to those without the disorder, a result that echoes previous findings in animal studies.

"Clearly, there is a correlation, and we are a long way from proving that sleep apnea causes cancer or contributes to its growth," says Nieto, an expert in sleep epidemiology. "But animal studies have shown that the intermittent hypoxia (an inadequate supply of oxygen) that characterizes sleep apnea promotes angiogenesisincreased vascular growth--and tumor growth. Our results suggest that SDB is also associated with an increased risk of cancer mortality in humans."

Dr. Nieto will present his study May 20 at the American Thoracic Society 2012 International Conference in San Francisco. It will be published in American Journal of Respiratory and Critical Care Medicine.

The team of University of Wisconsin-Madison investigators led by Nieto conducted this research in collaboration with Dr. Ramon Farr, professor of physiology at University of Barcelona, Spain. In a separate study also presented at the ATS conference, Dr. Farr's group showed that the effect of intermittent hypoxia on cancer growth is considerably stronger in lean mice than in obese mice.

The Wisconsin researchers examined 22-year mortality data on 1,522 subjects from the Wisconsin Sleep Cohort. This cohort is a longitudinal, community-based epidemiology study of sleep apnea and other sleep problems that begun in 1989 under the leadership of Dr. Terry Young, also a member of the UW population health sciences faculty. The cohort began was a random sample of Wisconsin state employees.

The participants undergo overnight sleep studies that include polysomnography an all-night recording of sleep and breathing and many other tests at four-year intervals. The studies are conducted in a specially designed unit at the federally funded UW Institute for Clinical and Transitional Research Center (ICTR).

After adjustment for age, sex, body mass index, and smoking, Nieto's study found that both all-cause and cancer mortality were associated with the presence and severity of SDB in a dose-response fashion. People with severe SDB died of cancer at a rate 4.8 times higher than people with no sleep breathing problems.

These associations were similar after excluding the 126 subjects who had used continuous positive airway pressure and were stronger among non-obese subjects than obese subjects.

"In our large population-based sample, SDB was associated with an elevated risk of cancer mortality," concluded Dr. Nieto. "Additional studies are needed to replicate these results. If the relationship between SDB and cancer mortality is validated in further studies, the diagnosis and treatment of SDB in patients with cancer might be indicated to prolong survival."


'/>"/>

Contact: Susan Lampert Smith
ssmith5@uwhealth.org
608-262-7335
University of Wisconsin-Madison
Source:Eurekalert

Related medicine news :

1. OHSU study: Misdiagnosis of MS is costing health system millions per year
2. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
3. Study: More Pre-Teens Get Vaccines When Middle Schools Require Them
4. Study: No link between depression, nasal obstruction
5. Study: Insomnia takes toll on tinnitus patients
6. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
7. Study: Low bone density medications may have protective effect on endometrial cancer
8. Study: US tobacco-control efforts prevented nearly 800,000 cancer deaths between 1975 and 2000
9. Study: Sleep gets better with age, not worse
10. Study: Over 100,000 Californians likely to miss out on health care due to language barriers
11. Study: No Significant Rise in Seizure Risk From Common Kids Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... “Engineering Bubbles,” an oil painting submitted ... ARRS Art Forum held recently at the Annual Meeting in Los Angeles. The first ... ARRS members and Annual Meeting attendees. , “Through art I hope to ...
(Date:5/2/2016)... ... May 02, 2016 , ... Over $60 Billion is spent ... pet gear and toys, leading product review site for Toys, Tots, Pets & More ... at their Spring Showcase at the Metropolitan Pavilion in New York City. , ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... has announced a new Specialty Pharmacy Patient Satisfaction Award that will recognize specialty ... the quarterly results from Zitter Health Insights’ Specialty Pharmacy Patient Satisfaction Survey compiled ...
(Date:5/2/2016)... ... ... According to an American Psychological Association article, the Centers for Disease ... of 18. Of those who survive, many still face effects as they reach adulthood. ... new book, Lyah! Lyah! Pants on Fyah!, she shares stories from women who are ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... Research & Analytics EVP and GM Jim Callandrillo and Duane Reed, VP ... 55th Annual Pharmaceutical Business Intelligence and Research Group (PBIRG) General Meeting ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... NEW YORK , May 2, 2016 /PRNewswire/ ... Series B financing of Graybug Vision, Inc. Graybug ... to developing therapies that may transform care for ... and glaucoma.  Graybug Vision,s technology was first developed ... out into a startup venture. ...
(Date:4/29/2016)... 2016  In the next ten years, the ... systems dependent on CRTs monitors to those reliant on ... Medical monitors and will automatically sync to existing ... foreseeable benefits to this technological advancement, it also ... to be replaced in order to be LCD ...
(Date:4/29/2016)... -- Glycotope GmbH, a clinical-stage immuno-oncology company ... of Dr. Alfredo Zurlo as Chief Medical ... many years clinical experience and a proven track record ... was at Mologen AG where he was Chief Medical ... Zurlo held various positions at F Hoffmann La Roche ...
Breaking Medicine Technology: