Navigation Links
UW scientists discover why human body cannot fight HIV infection
Date:7/12/2012

University of Washington researchers have made a discovery that sheds light on why the human body is unable to adequately fight off HIV infection.

The work, directed by Dr. Michael Gale, Jr., a professor in the Immunology Department, will be featured in the August print issue of the Journal of Virology.

The researchers discovered that the viral protein vpu, which is created by HIV during infection, directly interferes with the immune response protein IRF3 to dampen the ability of the immune system to protect against virus infection.

"By understanding exactly what HIV does to hamper the innate immune response during early infection, we can develop a clearer picture of how the virus is able to evade immunity to establish a long-term infection," said Dr. Brian Doehle, a postdoctoral fellow and lead author of the article.

The research expanded on an earlier discovery by the Gale lab that HIV directly antagonizes the early innate immune response in infected cells by impairing IRF3 function.

The new studies found that the HIV protein vpu specifically binds to the immune protein IRF3 and targets it for destruction, thereby, preventing IRF3 from functioning to trigger an immune response within the infected cell.

The scientists also found that HIV strains engineered to lack vpu, which is made during infection, did not impair the immune response.

"We have effectively identified a new Achilles heel in the arsenal that HIV uses to overcome the defenses present in the body's immune system", stated Dr. Gale. "This knowledge can be used to design new HIV antiviral therapeutics that prevent vpu from interacting with IRF3 and targeting it for destruction, thus enhancing immunity.

The development of new HIV antiviral therapeutics is critical to successfully treating HIV-infected people. Even though HIV antiviral therapeutics have already been developed and can effectively treat HIV infections, over time they lose their effectiveness due to the ability of the virus to adapt and spread despite the therapy, said Gale. "Therefore, the identification of new targets for treatment therapy is essential to providing the most effective treatment for HIV-infected patients".

Gale's laboratory has already begun translating the knowledge from these discoveries to tracking the molecular events that occur in patients during infection.

Arjun Rustagi, an MD/PhD student in the UW Medical Scientist Training Program, has developed a procedure to measure IRF3 activity in human blood cells. This new methodology will be used to measure IRF3 function over the course of HIV infection -- from the early stages of acute infection to the later stages of chronic infection that lead to AIDS.

By linking IRF3 function with infection over time, researchers will be able to understand how antiviral therapeutics that are designed to improve IRF3 function might impact the overall course of the disease in an HIV-infected individual.


'/>"/>
Contact: Bobbi Nodell
bnodell@uw.edu
206-543-8309
University of Washington
Source:Eurekalert

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... ... August 23, 2017 , ... Arizona ... hospitals nationally that earned the designation of High Performing Hospitals by U.S. News ... performing indicates a hospital was significantly better than the national average in a ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... Golden Bridge Awards® - for Risk Management Solution Innovations and Security Solution for ... online platform released in 2017 and its DHS SAFETY Act-designated enterprise security assessment ...
(Date:8/22/2017)... ... August 22, 2017 , ... The ... health is as simple as eating healthy foods. But this well-known piece of ... making insulin, or breaking apart carbohydrates—depends not only on properties of the food ...
(Date:8/22/2017)... ... August 22, 2017 , ... Nurses at Apple Rehab Watch ... Cove, recently received training and certification in Closed Pulse Irrigation™ (CPI) for ... five-star rating from the Centers for Medicare and Medicaid Services, to have a CPI ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Covert ... the creation of published author, Julianne Hale, a consultant for the Intelligence Community. ... counter-terrorism expert focusing on the Near East region. Julianne has written hundreds ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017 Insightin Health, provider ... retention, and engagement, announced the selection of ... Product Development, effective as of February 2017. In this ... implementation strategy for our clients. Wood brings with ... consulting and business analytics within the healthcare industry. ...
(Date:8/7/2017)... DUBLIN , Aug. 7, 2017  Endo International ... has reached agreements to resolve virtually all known U.S. ... in discussions to resolve the known remaining U.S. claims ... installment payments beginning in the fourth quarter of 2017 ... part of its second quarter 2017 results, the Company ...
(Date:8/2/2017)... , Aug. 2, 2017 Fenita ... Who as a Pinnacle Lifetime Professional in the ... Account Manager at Turing Pharmaceuticals, AG. Her skills ... and relationship building.                ... than 25 years of experience as a highly ...
Breaking Medicine Technology: