Navigation Links
UW researchers discover the brain origins of variation in pathological anxiety
Date:3/25/2013

Madison, Wis. New findings from nonhuman primates suggest that an overactive core circuit in the brain, and its interaction with other specialized circuits, accounts for the variability in symptoms shown by patients with severe anxiety. In a brain-imaging study to be published online today in the Proceedings of the National Academy of Sciences (PNAS), researchers from the University of Wisconsin School of Medicine and Public Health describe work that for the first time provides an understanding of the root causes of clinical variability in anxiety disorders.

Using a well-established nonhuman primate model of childhood anxiety, the scientists identified a core circuit that is chronically over-active in all anxious individuals, regardless of their particular pattern of symptoms. They also identified a set of more specialized circuits that are over- or under-active in individuals prone to particular symptoms, such as chronically high levels of the stress-hormone cortisol.

"These findings provide important new insights into altered brain functioning that explain why people with anxiety have such different symptoms and clinical presentations, and it also gives us new ideas, based on an understanding of altered brain function, for helping people with different types of anxiety,'' says Dr. Ned Kalin, senior author, chair of Psychiatry and director of the HealthEmotions Research Institute.

"There is a large need for new treatment strategies, because our current treatments don't work well for many anxious adults and children who come to us for help."

In the study, key anxiety-related symptoms were measured in 238 young rhesus monkeys using behavioral and hormonal measurement procedures similar to those routinely used to assess extreme shyness in children. Young monkeys are ideally suited for these studies because of their similarities in brain development and social behavior, Kalin noted. Variation in brain ac
'/>"/>

Contact: Susan Lampert Smith
ssmith5@uwhealth.org
608-890-5643
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers decode biology of blood and iron disorders mapping out novel future therapies
2. Researchers developing antiviral drug to combat contagious norovirus
3. WSU researchers to study effect of fatigue on attention
4. Patient Wishes Should Guide End-of-Life Care, Researchers Say
5. Researchers new method may sharpen microscopic images
6. Researchers tackle physician challenge of correctly ordering laboratory tests
7. Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
8. Brain Circuitry Yields Clue to Autism, Researchers Say
9. NIH-supported researchers identify new class of malaria compounds
10. Researchers develop new anatomically based classification for diagnosing cervical spinal stenosis
11. Mayo Clinic researchers develop test to gauge severity of concussions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Using frozen stool from healthy, unrelated donors was ... relapsing diarrhea caused by Clostridium difficile , ... Clinical Infectious Diseases and available online. ... equally effective whether given via a colonoscope or ... may make this promising treatment more readily available ...
(Date:4/23/2014)... John J. O,Shea, M.D., scientific director at the National ... has been named the 2014 recipient of the Ross ... peer-reviewed, open-access journal Molecular Medicine . The award ... York Academy of Sciences in Manhattan, followed by scientific ... is part of the National Institutes of Health. , ...
(Date:4/23/2014)... - Purdue University researchers have developed a way to ... by using tiny gold particles with tails of synthetic ... agricultural and biological engineering, used gold nanoparticles to target ... BRCA1 messenger RNA splice variants, which can indicate the ... these mRNA splice variants in a cell can be ...
(Date:4/23/2014)... NY, April 23, 2014Men whose testosterone falls below normal ... to be overweight and have heart disease and type ... identify testosterone-deficient men for further testing and possible treatment ... Men,s Health , a peer-reviewed publication from Mary Ann ... the Journal of Men,s Health website at ...
(Date:4/23/2014)... benefits of probiotics, antioxidants and other nutritional compounds, more ... industry is getting in on the action. But legitimate ... the industry is responding with clinical research to shore ... Chemical & Engineering News (C&EN), the weekly ... M. Bomgardner, a senior editor at C&EN, writes that ...
Breaking Medicine News(10 mins):Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2
... lead in the blood may signal a risk two times ... according to medical researchers. "Past studies (in cadavers) ... kidneys from individuals with cancer have higher lead levels," said ... Medicine. "But prior to this study, the identification of higher ...
... Waxman, a professor of oncology, was inspired to write a ... insight into his patients, fears, hopes, and the impact the ... Room, Waxman explores the relationship of patient and specialist, how ... actually mean when talking to their patients. Jonathan ...
... , MONDAY, Jan. 23 (HealthDay News) -- Despite ... lifelong risk for skin cancer, just 25 percent of 14-year-olds ... What,s more, behaviors linked to risky sun exposure increased ... in the sun and less use of sunscreen than when ...
... Research to Prevent Blindness (RPB) has awarded Massachusetts Eye ... $30,000 Medical Student Eye Research Fellowship. The award will support ... allow Ms. Shah to participate in research under the mentorship ... Pasquale in collaboration with Dr. Suzanne Freitag, Director of the ...
... at the Gladstone Institutes have identified a finely tuned ... healthy and fully formed beating heartoffering new insight into ... the door to one day developing therapies to fight ... paper being published online today in Nature Genetics ...
... , SUNDAY, Jan. 22 (HealthDay News) -- Doing yoga ... known as "hot yoga" -- is increasing in popularity, but it ... high temperatures may be dangerous for people with certain health conditions, ... the rehabilitation department at the Hospital for Special Surgery in New ...
Cached Medicine News:Health News:Lead blood levels may increase smokers' risk for kidney cancer 2Health News:Lead blood levels may increase smokers' risk for kidney cancer 3Health News:True stories from the cancer ward 2Health News:Only 1 in 4 Young Teens Uses Sunscreen Regularly, Study Finds 2Health News:Gladstone scientists identify genetic mechanism linked to congenital heart disease 2Health News:Avoid Getting Scorched by 'Hot Yoga' 2
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... Forecast – Worldwide Analysis ... Market Analysis Insulin ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Delivery Systems -- Focus on End Users ... STUDY OBJECTIVES A drug delivery ...
(Date:1/15/2014)...  A novel wearable injector slightly larger than an Oreo cookie ... self-inject prescription drugs in the large doses required to treat ... deficiencies, and genetic disorders.  An emerging biologic ... according to analysts.   Many of these drugs will require a ...
Breaking Medicine Technology:Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2
Features a twist-on backswitch, with a diffused, cobalt blue light beam....
Heavy duty, all purpose illuminator available in black only. Unique Clip Switch automatically turns off when returned to pocket. Pre-focused lens tip Heine XHL Halogen bulb for bright, concentrated l...
... the latest in auto focus. The Genie ... monitors or televisions to create a color ... unique viewing needs. Using advanced technology to ... Genie Pro allows a user to simultaneously ...
The Miniviewer magnifies text or color images 5 to 15 times. MiniViewers superior magnification, light weight and portable design offer you the ultimate in flexibility....
Medicine Products: