Navigation Links
UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
Date:9/4/2007

Charlottesville, Va., September 4, 2007 A University of Virginia researcher has been awarded a $3.6 million grant from the National Institute of Allergy and Infectious Diseases to combat a growing international health crisis.

Dr. Richard Guerrant, founder of UVas Center for Global Health, plans to take a unique approach to treating the bacterium Clostridium difficile, which is growing increasingly resistant to certain antibiotics that work against bacteria of the colon. Clostridium difficile (C. diff) is a bacterium that causes diarrhea and can lead to more serious intestinal conditions such as colitis.

This is a huge problem which has been getting worse since the mid-1980s. Previously healthy young people are becoming ill with the disease and the national mortality rate from the disease has more than doubled in the last few years, Guerrant says.

Patients who are most at risk from C. diff have traditionally been older or have taken antibiotics for an extended period of time. The antibiotics eradicate the beneficial bacteria which all people have in their digestive tract, leaving the drug resistant C. diff to flourish. An estimated 5 to 7 percent of residents of assisted living and nursing facilities are infected with the bacterium.

The Centers for Disease Control reports there have been C. diff outbreaks in hospitals in 23 states. The drug-resistant strain has been blamed for more than 100 deaths over an 18-month period at a hospital in Quebec. The bacteria are found in feces. Infection can occur when people touch items or surfaces contaminated with feces.

C. difficile produces two toxins which cause the body to react with diarrhea, fever, loss of appetite, nausea and abdominal pain. Because the bacterium is proving resistant to antibiotics, Guerrant proposes countering the effects of the toxins instead of targeting the bacterium.

The current treatments have been to try a new antibiotic on the bacterium, which kills even more of the beneficial bacteria and allows C. diff to continue ravaging the patients, Guerrant says. By rendering the toxins harmless, we hope we can keep the debilitating effects of C. diff from proving fatal.

Guerrant says pilot data show this approach has great promise and he plans to collaborate with other UVa scientists and a pharmaceutical company to develop the treatment.


'/>"/>

Contact: David Foreman
davidforeman@virginia.edu
434-924-2242
University of Virginia Health System
Source:Eurekalert

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
4. New Hair in 15 Days Could Now Be A Possibility Say Researchers
5. Researchers at Cornell University as been reported using research fund by false claims
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. Gene researchers make Malaria-resistant mosquito
9. Researchers developed world’s smallest toothbrus
10. Researchers discover receptor cells that can cause epilepsy
11. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Pa. (PRWEB) , ... October 13, 2017 , ... While ... dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. ... to medication in darkness or restricted lighting. As such, it eliminates the need to ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West ... in innovative solutions for injectable drug administration, today announced ... the market opens on Thursday, October 26, 2017, and ... results and business expectations at 9:00 a.m. Eastern Time. ... or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an update ... Puerto Rico , where the company manufactures ... Following a comprehensive onsite assessment, the ... temporary loss of power and minimal water damage due ... have resumed, and the company expects to return to ...
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
Breaking Medicine Technology: