Navigation Links
UVA researchers find important clue to immune infertility
Date:9/12/2007

CHARLOTTESVILLE, VA (Sept. 12, 2007) Most of us have never heard of immune infertility, yet it prevents many prospective parents from conceiving.

Immune infertility is one of 80 autoimmune disorders, a group that includes better-known diseases like Multiple Sclerosis and Type 1 Diabetes. This reproductive disorder affects both men and women, causing their immune systems to wage war on sperm.

A recent discovery at the University of Virginia Health System may help pinpoint what molecules assist the immune system in attacking sperm. In the July 2007 issue of Gene, UVa researchers reported finding a new human protein, radial spoke protein 44 (RSP44). Exposure to RSP44 caused infertile men to produce antisperm antibodies (ASA) in their serum.

Weve spent several years looking for sperm molecules that evoke antibody responses in humans, says Dr. John C. Herr, director of UVas Center for Research in Contraceptive and Reproductive Health. The identification of RSP44 gives us additional insight into immune infertility and may prove useful in diagnosing the disorder in a subset of men. RSP44 will likely not be a dominant antigen in everyone.

Researchers believe that RSP44 belongs to a highly conserved and ancient gene family. It can be found in all men, residing in the sperm tail at the center of a structure known as the axoneme. There, it clusters around microtubules involved in sperm movement. Both men and women have RSP44 in hair-like strands, called cilia, in the bronchioles of their lungs, the ventricles of their brains and the lumens of their thyroid gland.

The discovery of RSP44 also promises to broaden scientific thinking about the causes of immune infertility. Until now, researchers believed that ASA only targeted the surface of the sperm membrane.

Because RSP44 is located in the heart of the axoneme, it doesnt appear to be directly involved in ASA binding at the sperm membrane. Identifying RSP44 as an an
'/>"/>

Contact: Ellen McKenna
ecm6n@virginia.edu
434-982-4490
University of Virginia Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers identify the early makers of Neonatal Sepsis
4. OHSU Researchers Announce New Discovery
5. Researchers Identify Gene Connected To Bipolar Disorder
6. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
7. Researchers trick Alzheimers Enzyme
8. Researchers find new HIV hiding place
9. Gene researchers make Malaria-resistant mosquito
10. New Hair in 15 Days Could Now Be A Possibility Say Researchers
11. Researchers developed world’s smallest toothbrus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... Viejo, CA (PRWEB) June 02, 2015 TranSlice: ... with a new style. TranSlice: Reveal allows Final Cut Pro ... and growing lines to reveal their next screen. , TranSlice ... unique style. Final Cut Pro X users can ... and growing lines. , With every panel orientation and direction ...
(Date:6/2/2015)... Amercanex, the American Cannabis Exchange, ... become Amercanex’s new Chief Technology Officer. Amercanex is ... cultivators, wholesale distributors and retail vendors can buy, ... transparent intra-state market. , Jim Miller is an ... space, helping innovative technology companies deliver on their ...
(Date:6/2/2015)... June 02, 2015 Thermi, formerly ... company has successfully transitioned into its new company ... to the company’s continued rapid worldwide expansion and ... of over 25 Thermi employees, including those of ... teams. , “As one of the fastest growing ...
(Date:6/2/2015)... Atlantic Spine Center , a ... three locations in New Jersey, announces the opening of ... facility is at 1045 Park Avenue (at East 86th ... can be arranged by calling 1-844-912-2406. , Dr. ... Center, has been a pioneer in the development of ...
(Date:6/2/2015)... June 02, 2015 Specialty Technical ... compliance and risk solutions , and Radar today ... management effectiveness gap-improvement program. , All organizations need ... on objectives. Organizations not only assess and treat ... to do this (risk managing) thereby embedding these ...
Breaking Medicine News(10 mins):Health News:Announcing the release of TranSlice Reveal from Pixel Film Studios - Professional Split Screen Transitions for FCPX. 2Health News:Amercanex Names Jim Miller to CTO Position 2Health News:Thermi Moves to New Corporate Headquarters as Rapid Company Expansion Continues 2Health News:Renowned Endoscopic Spine Surgeon Dr. Kaixuan Liu Announces Opening of Park Avenue Office 2Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 2Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 3Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 4
... , Feb. 16 In these difficult times in ... bringing money and services into the Reno area.   ... Start Learning Disabilities Programs Inc. is providing cutting edge educational and ... The $200,000.00 represents a net investment into the area. ...
... University researchers have developed a hands-free alternative to cell phone ... doing it, make it safer," said Juan Gilbert, professor and ... Computing. He said one problem with banning texting while ... He said it will be difficult for police to can,t ...
... radiological evidence suggest broken leg, malaria and genetic disorder ... King Tut probably wasn,t killed by a vengeful wife ... a broken leg and several inherited disorders that rendered ... new DNA and radiological evidence suggests. , "What ...
... Washington, DC Combining tamoxifen, the world,s most prescribed breast ... feverfew may prevent initial or future resistance to the drug, ... reported online in FASEB Feb. 12, provides ... also tests a novel way to get around it. "A ...
... them with a laser has been shown to be a ... occur in places where a laser light can,t reach? Scientists ... directing gold nanoparticles into the nuclei of cancer cells, they ... them where they lurk. The research appeared as a communication ...
... peer-reviewed international journal of the American Cancer Society, ... in its Jan. 1 edition, demonstrating disparities in ... white women. The HealthCore study reiterates ... populations using government health programs that African-American ...
Cached Medicine News:Health News:Reno Children With Disabilities Profit From a Little Known but Internationally Recognized Non-Profit Organization as it Quietly Crosses the $200,000.00 Mark in Service Investment Into the Reno Area 2Health News:King Tut's Demise Gets New Explanation 2Health News:King Tut's Demise Gets New Explanation 3Health News:GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen 2Health News:GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen 3Health News:Using gold nanoparticles to hit cancer where it hurts 2Health News:Cancer publishes study confirming disparity in breast cancer treatment 2
(Date:6/1/2015)... June 2, 2015 Islamic ... mainstream reporting standard for Corporate Sustainability and Social ... big step in CSR: The Islamic Reporting Initiative (IRI). ... last month, the Islamic Reporting Initiative is rapidly ... The latest members to express support for ...
(Date:6/1/2015)... -- LaunchPad Medical, LLC announced today that it has ... Corporation,s (NYSE: SYK ) bone adhesive technology, ... Under the terms of the agreement, LaunchPad has ... this technology which is covered by four issued ... from multiple pre-clinical animal studies.  LaunchPad will seek ...
(Date:6/1/2015)... WOODBRIDGE, ON , June 1, 2015 /PRNewswire/ ... a specialty pharmaceutical company with a focus on ... health, announced its operational highlights and financial results ...  All dollar amounts referenced herein are in Canadian ... to deliver on its business strategies despite its ...
Breaking Medicine Technology:Call for Partners: Islamic CSR 2LaunchPad Medical Executes Definitive License Agreement with Stryker for Novel Bone Adhesive Technology 2Pivotal Therapeutics Announces First Quarter Financial Results 2Pivotal Therapeutics Announces First Quarter Financial Results 3Pivotal Therapeutics Announces First Quarter Financial Results 4Pivotal Therapeutics Announces First Quarter Financial Results 5
For reconstruction, trauma and chronic stenosis of canalicular system. Medical grade silicone tubing (tapered at one end). Blue polypropylene suture. Box of 3, sterile....
Recommended to insert plug portion of all monocanalicular intubation systems into punctum....
For proper plug sizing....
For proper plug sizing....
Medicine Products: