Navigation Links
UTHealth, Swedish researchers uncover mystery in blood clotting disorder
Date:8/27/2013

HOUSTON (Aug. 27, 2013) Fifteen years ago, a hematologist came to Dianna Milewicz, M.D., Ph.D., with a puzzle: Multiple generations of an East Texas family suffered from a moderately severe bleeding disorder, but it wasn't hemophilia.

"No surgeon would do elective surgery because they bled too much after surgery," said Milewicz, professor and director of the Division of Medical Genetics at The University of Texas Health Science Center at Houston (UTHealth). "So we collected DNA and plasma from the family and were able to determine that a genetic variant in the Factor V gene was causing production of an abnormal form of the Factor V protein, which we called FV-Short. Factor V is a protein known to be important for the blood to clot."

But her team at the UTHealth Medical School couldn't pinpoint exactly how the variation was causing the clotting problem until they collaborated with Bjrn Dahlbӓck, M.D., Ph.D., from Lund University, Malm, Sweden.

"Dr. Dahlbӓck is a world expert on Factor V and he was very excited about the research," said Milewicz, who holds the President George H.W. Bush Chair in Cardiovascular Research. She is also on the faculty of The University of Texas Graduate School of Biomedical Sciences and director of the John Ritter Research Program in Aortic and Vascular Diseases at UTHealth.

"I was indeed very excited when hearing about the puzzling results because the knowledge at the time on the role of FV in coagulation could not explain the bleeding disorder. It has been a great privilege to work with Dr. Milewicz and her colleagues to decode the unexpected and intriguing mechanisms on how FV-Short caused the bleeding disorder," said Dahlbck who holds the chair as professor of Blood Coagulation Research at Lund University, Malm, Sweden.

The results were published in today's online issue of the Journal of Clinical Investigation. Milewicz and Dahlbck are senior co-authors.


'/>"/>

Contact: Deborah Lake
deborah.m.lake@uth.tmc.edu
713-500-3304
University of Texas Health Science Center at Houston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UTHealth, French researchers discover gene defect for new syndrome
2. Lifestyle changes could prevent 400 cardiac events and 200 deaths in Swedish PCI patients
3. Complementary and alternative medicine studied in Swedish surgical care
4. Feinstein Institute Scientist Wins Crafoord Award from Royal Swedish Academy of Sciences for Arthritis Research
5. Surgery is superior to radiotherapy in men with localized PCa, says prize-winning Swedish study
6. Swedish study suggests reduced risk of dementia
7. Extreme Birth Weights Tied to Autism in Swedish Study
8. NIH awards $20 million over 5 years to train next generation of global health researchers
9. Researchers develop a new cell and animal model of inflammatory breast cancer
10. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
11. Researchers Find Gene Mutations That May Be a Key to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Frankfurt, Germany (PRWEB) September 19, 2014 ... today that its new ND® Infusion Catheter ... University of Frankfurt. , The study commenced on September ... Cardiology. The use of the new catheter demonstrated a ... commonly known as stem cells. “We are at the ...
(Date:9/19/2014)... QueenBeeTickets.com has the largest ticket inventory that ... tour set to begin on January 21 of 2015, discount ... the secure website. , Click Here to view ... QueenBeeTickets.com. , The Plain Spoken Tour has recently been announced, ... for a show coming to their local area. Presales have ...
(Date:9/19/2014)... and other adult family members living without minors in ... with young children or adolescents to eat family meals ... research suggests. , The study is the first large-scale ... a substantial amount of research has focused on health ... eating patterns have not been widely studied in adult-only ...
(Date:9/19/2014)... 2014 A McLean County ... (case 14-L-1175), following a failed hip replacement using a ... DePuy Orthopaedics Inc. and Johnson & Johnson over allegations ... Group, a nationally known personal injury law firm, represents ... in litigation involving defective hips. , According to the ...
(Date:9/19/2014)... 19, 2014 VogueQueen.com has ... that will make ladies more beautiful at their weddings. ... everyone can afford. The company’s new products are made ... offering great savings for all the global clients. ... extremely beautiful. I have ordered several items on its ...
Breaking Medicine News(10 mins):Health News:First-in-man procedure utilizes a new method of stem cell delivery 2Health News:First-in-man procedure utilizes a new method of stem cell delivery 3Health News:John Mellencamp Plain Spoken Tour Tickets: QueenBeeTickets.com Delights Customers with Discount Tickets for Mellencamp’s 80-City 2015 Concert Tour with Carlene Carter 2Health News:Even without kids, couples eat frequent family meals 2Health News:Even without kids, couples eat frequent family meals 3Health News:Even without kids, couples eat frequent family meals 4Health News:Flood Law Group Comments on Recent Hip Replacement Lawsuit 2Health News:VogueQueen.com’s New Line Of Cheap Wedding Dresses Aims To Attract Chic Ladies 2
... the World Federation for Mental Health reveals that patients ... life suffers because of their disease. ,Bipolar disorder ... elation and depression. Also known as manic-depressive illness that ... population. This is a chronic condition and most of ...
... been around now for almost 40 years for treatment ... it maybe useful in treating cancer as it has been ... This was reported by international team of scientists. Leslie Wilson, ... Santa Barbara, The results are published in online edition of ...
... Researchers have found that teenage girls living in temperate countries ... in life if they took supplements of Vitamin D in ... is low. The sun is important for formation of the ... ,The vitamin supplement would help to strengthen bones for later ...
... Losing one kilo of weight may be equivalent to losing ... from osteoarthritis of the knee. ,Researchers from the Wake ... of exercise and weight loss on the osteoarthritis of the ... 5% of the body weight in obese elderly patients can ...
... cancer is the most common and deadly cancer worldwide. About ... out of which // 85% will die before 2010. Habit ... is fastly increasing in low and middle income countries. The ... smoking related disease causes 5 million deaths a year. ...
... to a recent study researchers say the drug orlistat ... least a year without // major side effects in ... the intestines to absorb fat by up to 30 ... taking orlistat passes through the body without being digested ...
Cached Medicine News:Health News:Vitamin D Supplement in Teenage Girls essential in Winter months 2Health News:Aggressive Tobacco taxation policy can reduce cigarette smoking, 2
(Date:9/18/2014)... 2014 MiMedx Group, Inc. (NASDAQ: ... marketer of patent protected regenerative biomaterials and bioimplants ... it has entered into a distribution agreement with ... its dehydrated human amnion/chorion membrane ("dHACM") allograft products ... a private label basis. The MiMedx ...
(Date:9/18/2014)... 2014  Zacks.com announces the list of stocks featured ... Research analysts discuss the latest news and events impacting ... the blog include the Avanir Pharmaceuticals (Nasdaq: AVNR - ... Free Report ), Orexigen (Nasdaq: OREX - Free ... ) and Gilead (Nasdaq: GILD - Free Report ...
(Date:9/18/2014)... YORK and PLAINSBORO, N.J. ... announced today its support of the National Hemophilia ... Care , which provides support to people with ... physical and psychosocial challenges that can impede disease ... six modules, Communication With Your Provider About ...
Breaking Medicine Technology:MiMedx Signs Distribution Agreement With Zimmer 2MiMedx Signs Distribution Agreement With Zimmer 3The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 2The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 3The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 4The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 5The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 6Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 2Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 3
... level of blood oxygenation can be an essential ... in the clinical setting is often desirable. In ... technology into easily used point-of-care devices, recent products ... values., ,HemoCue, Inc., Lake Forest, Calif., says that ...
... the context of many clinical laboratories, automated production in ... years. In automobile assembly, for example, automated lines fabricate ... The result has been vastly improved products, far fewer ... These days, only a handful of luxury and sports ...
Cached Medicine Technology:Hemoglobin Testing at the Point of Care 2Hemoglobin Testing at the Point of Care 3Lab Automation Networks Proliferating 2Lab Automation Networks Proliferating 3Lab Automation Networks Proliferating 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: