Navigation Links
UT researchers to study massive transfusion at major trauma centers
Date:10/8/2008

The U.S. Department of Defense has awarded The University of Texas Health Science Center at Houston a $9.2 million grant to conduct a multi-center clinical trial that could lead to an improved survival rate for trauma patients both soldiers and civilians -- who require massive blood transfusions.

The university's Center for Clinical and Translational Sciences (CCTS) is contracting with the U.S. Army Institute of Surgical Research to serve as the data coordination center for a Prospective, Observational, Multi-center Massive Transfusion Trial (PROMMTT). Clinical trial sites for the two-year study will include Memorial Hermann Texas Medical Center and at least nine other trauma centers.

"Those first few hours after injury are critical, and we'll be looking at what happens minute-to-minute that determines whether these patients live or die," said Col. John Holcomb, M.D., co-investigator, director of the Center for Translational Injury Research (CeTIR) and professor in the Department of Surgery at The University of Texas Medical School at Houston.

"This has never been done before. With these data, we'll eventually be able to pinpoint what works and what doesn't, develop standards for transfusion ratios and greatly improve the mortality rate, which currently is as high as 40 to 70 percent, depending on the trauma center. We will be able to design prospective randomized trials with quality data," Holcomb said. "Finally, what we learn in the civilian population will also benefit the military."

From the time a trauma patient is admitted to the hospital to the time of discharge or death, healthcare providers will be logging data on vital signs, units of packed red blood cells, fresh frozen plasma and platelets, as well as medications and other healthcare information.

Jiajie Zhang, Ph.D., co-investigator, holder of the Dr. Doris L. Ross Professorship and the associate dean for research at The University of Texas School of Health Information Sciences at Houston, is leading the effort to design a secure, web-based informatics system that will make it possible to collect these data by the patient's bedside. The system also will allow for subsequent data management and analysis for clinical and translational research.

Mohammad Hossein Rahbar, Ph.D., director of the CCTS's Biostatistics, Epidemiology and Research Design (BERD) Component, is the principal investigator who will establish and manage the consortium of trauma centers and coordinate the data collection, data management and statistical analysis. Deborah Del Junco, Ph.D., associate professor at the CCTS-BERD, is among the co-investigators he will work with on the project.

"It is a very ambitious, meaningful project that draws upon the talents of those who are part of the CCTS," said Rahbar, who also holds a faculty appointment at The University of Texas School of Public Health. "The findings of this study could have long-term global implications, and it will set the stage for future studies."

Peter Davies, M.D., Ph.D., the university's executive vice president of research, said, "We are delighted with the success of Dr. Rahbar and his colleagues, particularly Dr. Del Junco, in competing for this very important award. It is an outstanding example of the ways that our grant to establish the CCTS is allowing us to transform clinical and translational research at our university. In addition, with the very recent recruitment of Dr. John Holcomb to our campus and the formation of the new Center for Translational Injury Research, this PROMMTT award can serve as the foundation for an enormously exciting program of trauma research at the UT Health Science Center at Houston."


'/>"/>

Contact: Meredith Raine
Meredith.Raine@uth.tmc.edu
713-500-3050
University of Texas Health Science Center at Houston
Source:Eurekalert

Related medicine news :

1. Duke researchers show reading can help obese kids lose weight
2. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
3. Researchers create first model for retina receptors
4. Researchers Report Stem Cell Advance
5. ALS Patients and Researchers Unite in Boston for 4th Annual Leadership Summit
6. OHSU Cancer Institute researchers study breathing during radiation
7. Satellite Healthcare Announces 2008 Norman S. Coplon Extramural Grants : Grants Foster Next-Generation Kidney Disease Researchers
8. New leukemia signal could point way to better treatment, Stanford researchers find
9. Penn researchers use honeybee venom toxin to develop a new tool for studying hypertension
10. Johns Hopkins researchers suppress hunger hormone
11. Penn researchers identify natural tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... , ... February 21, 2017 , ... ... acquisition of the predictive analytic firm Predixion’s Healthcare IT practice. Predixion, which raised ... and is backed by giants including Accenture, GE Ventures, and Software AG ...
(Date:2/21/2017)... ... 21, 2017 , ... Along with Valentine’s Day, February marks American Heart Month, ... can lead to a lifetime of heart health. In addition, it is a ... , The Athletic Trainers’ Society of New Jersey (ATSNJ) is urging sports programs to ...
(Date:2/20/2017)... ALEXANDRIA, VA (PRWEB) , ... February 20, 2017 , ... ... with Cambridge Healthcare to open and operate a state-of-the-art memory care community in Alexandria, ... of 2018 on a site just outside of Old Town. , The three-story ...
(Date:2/20/2017)... ... February 20, 2017 , ... The StayWell Company and ... providers better manage patient health risks, foster behavior change and improve health literacy among ... world, will present a demonstration of its video capability at StayWell booth 3443 during ...
(Date:2/20/2017)... ... February 20, 2017 , ... Houston dentist , Dr. ... care at his office, Antoine Dental Center. Emergency dentistry encompasses many treatments for ... at risk for serious complications and often experience severe pain. Not only does ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... 2017  Luminex Corporation (NASDAQ: LMNX ) (the ... the initiation of a quarterly cash dividend to its shareholders, ... will be payable on April 14, 2017 to shareholders of ... 2017. The board of directors intends for ... $0.06 to holders of its common stock, representing a planned ...
(Date:2/21/2017)... 2017 Medical Oxygen Concentrators Market: Overview ... Medical oxygen concentrators are used by ... Patients having low level of oxygen in their ... concentrators are to be used only with prescription ... oxygen concentrators work either on rechargeable lithium batteries ...
(Date:2/21/2017)... 2017 Scientists From Two Companies ... Plastic Industry  ... STEER, creator of advanced materials platform ... fields of plastics, pharmaceuticals, food and nutraceuticals, biomaterials and biorefining, ... Germany , a leading science & ...
Breaking Medicine Technology: