Navigation Links
UT Southwestern study suggests new treatment target for deadly brain tumors
Date:8/1/2012

DALLAS Aug. 1, 2012 A study by UT Southwestern Medical Center researchers published online today in Nature reveals new insight into why the most common, deadly kind of brain tumor in adults recurs and identifies a potential target for future therapies.

Glioblastoma multiforme (GBM) currently is considered incurable. Despite responding to initial therapy, the cancer almost always returns. GBM is a fast-growing, malignant brain tumor that occurred in 15 percent of the estimated 22,000 Americans diagnosed with brain and nervous system tumors in 2010. The median survival rate is about 15 months, according to the National Cancer Institute.

"We identified a subset of brain tumor cells that are slower growing or remain at rest, and appear to be the source of cancer recurrence after standard therapy in which the drug temozolomide is given to stop the tumor's growth," said Dr. Luis Parada, chairman of developmental biology and director of the Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration. "Current therapy targets fast-growing tumor cells but not those responsible for new tumors. To the best of our knowledge, this is the first identification of a cancer stem-like cell in a spontaneously forming tumor inside a mammal."

Using a genetically engineered mouse model of GBM, the researchers found that the resting tumor cells act more like stem cells the non-cancerous cells the body uses to repair and replenish itself which exist in a resting state until needed, he explained.

The existence of cancer stem cells in solid tumors remains controversial, Dr. Parada said, with some scientists in the field taking the concept for granted and others rejecting it outright. In addition, the definition of a cancer stem cell is a moving target, hence the use of the term stem-like cell in this study, he said.

"We a
'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. UT Southwestern study shows treating diabetes early, intensively is best strategy
2. Poor Sleep Hampers Vaccine Effectiveness: Study
3. Medical complications in hospitalized children: The Canadian Paediatric Adverse Events Study
4. Study identifies barriers to breast health care in Pakistan
5. New study suggests clinicians overlook alcohol problems if patients are not intoxicated
6. Even Mild Depression, Anxiety Hurts the Heart: Study
7. JAAOS study highlights success of nerve transfer surgery
8. Study finds people have difficulty controlling multiple chronic conditions
9. Smile! It Might Lower Your Stress Level, Study Shows
10. Less Invasive Surgery Safe for Harvesting Bypass Veins: Study
11. Canadians super-sizing Canadas Food Guide servings: York University study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern study suggests new treatment target for deadly brain tumors
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... say that once the virus takes hold in any country ... // Officials admitted that they are facing an uphill battle ... easily from person to person, triggering a pandemic. ,The ... poultry, one of the most crowded places on earth and, ...
... Clark Gable's son has been exposed as a drug addict ... ,According to contactmusic.com, the daughter Kaylee feels that her grandfather ... his son, actor John Clark Gable, now. , ,She ... I know if my grandfather were alive today it would ...
... to new things and accepts them, although medical transcription is not ... records in papers and are not well stocked in most cases. ... records., ,In contrast, in the US, medical case files are ... industry in the US is well established. It is more than ...
... Fifteenth Annual Meeting and Clinical Congress to be held ... discuss important benefits //of vitamin D and the problems ... ,Vitamin D has been in the new recently and ... attributed to it. Recent studies have highlighted its deficiency ...
... researchers say that the distinctive features of the heart ... of a genetic quirk that is linked to a ... ,Steve Ommen, M.D., director of Mayo’s HCM Clinic ... said that the currently available test was only able ...
... Brachytherapy, which is touted as the best and latest ... Sydney's Mater Hospital Radiotherpahy Department.// ,It is ... set to improve results with fewer side effects. ... the southern hemisphere, bringing together image-enhancing technology that builds ...
Cached Medicine News:Health News:Rising in career top charts is Medical transcription 2
(Date:1/14/2014)... -- Luminex Corporation (Nasdaq: LMNX ) today announced ... quarter of 2013 on Monday, February 3, 2014. A ... after the close of trading. (Logo: ... conference call to discuss the operating highlights and financial ... December 31, 2013 on February 3, 2014, at 5:00 ...
(Date:1/14/2014)... -- Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company of ... Home Medical Equipment, Inc. ("Progressive") of Clarion, PA ... acquisition were not disclosed. Progressive is a ... range of sleep, mobility, and respiratory products to customers in ... Pittsburgh markets. Progressive was founded in 2005 by ...
(Date:1/14/2014)... PLYMOUTH, Minn. , Jan. 14, 2014   NuAire ... for research, have come to agreement with Hitachi Koki ... service the Hitachi brand of centrifuges in North ... professionals throughout the United States and ... use, product benefits and features, options and accessories, training, pricing, ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... U.S. Food and Drug Administration is warning the public ... law enforcement personnel as part of a continued international ... The criminals call the victims -- who ... or via "telepharmacies" -- and identify themselves as FDA ...
... EDDA Technology, a leading provider of advanced computer ... successful commercial installation of its IQQA®-Liver Enterprise product ... one of the top performing living donor liver ... use EDDA Technology,s IQQA®-Liver Enterprise in conjunction with ...
Cached Medicine Technology:FDA Warns Public of Continued Extortion Scam By FDA Impersonators 2FDA Warns Public of Continued Extortion Scam By FDA Impersonators 3EDDA Technology Successfully Installs IQQA®-Liver at Mayo Clinic in Arizona 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: