Navigation Links
UT Southwestern study shows estrogen works in the brain to keep weight in check
Date:10/19/2011

DALLAS Oct. 20, 2011 A recent UT Southwestern Medical Center study found that estrogen regulates energy expenditure, appetite and body weight, while insufficient estrogen receptors in specific parts of the brain may lead to obesity.

"Estrogen has a profound effect on metabolism," said Dr. Deborah Clegg, associate professor of internal medicine and senior author of the study published Oct. 5 in Cell Metabolism. "We hadn't previously thought of sex hormones as being critical regulators of food intake and body weight."

The mouse study is the first to show that estrogen, acting through two hypothalamic neural centers in the brain, keeps female body weight in check by regulating hunger and energy expenditure. Female mice lacking estrogen receptor alpha a molecule that sends estrogen signals to neurons in those parts of the brain became obese and developed related diseases, such as diabetes and heart disease.

Similar results were not seen in male mice, although researchers suspect other unknown estrogen receptor sites in the brain play a similar role in regulating metabolism for males as well.

Estrogen receptors are located throughout the body, but researchers found two specific populations of estrogen receptors that appear to regulate energy balance for female mice.

The findings are potentially important for millions of postmenopausal women, many of whom have decided against hormonal replacement therapy. The study could lead to new hormonal replacement therapies in which estrogen is delivered to specific parts of the brain that regulate body weight, thereby avoiding the risks associated with full-body estrogen delivery, such as breast cancer and stroke.

Doctors stopped routinely recommending long-term estrogen therapy for menopausal women in 2002 when a Women's Health Initiative study showed the hormone also led to increased risk of cardiovascular disease.

"The role of estrogen in postmenopausal women continues to remain uncertain," Dr. Clegg said. "Current research is focused on the timing and the type of estrogen supplementation that would be most beneficial to women. Our findings further support a role for estrogens in regulating body weight and energy expenditure, suggesting a benefit of estrogen supplementation in postmenopausal women."


'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. UT Southwestern and University of Cape Town announce 5-year affiliation agreement
2. UT Southwestern, Parkland partner for $6.3 million NCI grant to improve colorectal cancer screenings
3. UT Southwestern scientist shares 2011 Nobel Prize in Physiology or Medicine
4. UT Southwestern launches hand transplant program
5. UT Southwestern support groups book reaches out to husbands, partners of women battling cancer
6. UT Southwestern ophthalmologist helps develop device for monitoring degenerative eye disease
7. UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
8. UT Southwestern pediatric urologist develops procedure to eliminate scarring in kidney surgeries
9. Drug shows improved kidney function for type 2 diabetics, UT Southwestern researchers report
10. UT Southwestern researchers uncover why ketamine produces a fast antidepressant response
11. UT Southwestern surgeons examine hypospadias repair efficacy for patients with differing anatomies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... September 21, 2017 , ... Demonstrating ... governmental public health departments have been awarded five-year accreditation status through the ... benefits of being served by a PHAB-accredited health department now extend to ...
(Date:9/21/2017)... Southborough, Mass. (PRWEB) , ... September 21, 2017 , ... ... for children with autism, announced today the election of Yie-Hsin Hung to the Board ... Yie-Hsin Hung join our Board of Directors. Ms. Hung is an invaluable addition to ...
(Date:9/21/2017)... ... September 21, 2017 , ... FlipBelt, the fitness brand that specializes ... to the athletic wear market with the launch of their FlipBelt Crops. , The ... essentials securely at their fingertips while at the gym, on the trail, or on-the-go. ...
(Date:9/20/2017)... ... September 20, 2017 , ... Reflections Recovery Center, a ... by The Joint Commission for chemical dependency and behavioral health services. , The ... care organizations that meet the commission’s rigorous standards. Accreditation by The Joint Commission ...
(Date:9/20/2017)... GLENDALE, Calif. (PRWEB) , ... September 20, 2017 ... ... 15th year of providing a voice for people who have kidney disease. The ... many writers to share their stories. Entrants needed to meet only one ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... , Sept. 5, 2017  Getinge, a ... created a vibrant charitable donation program -- "Color ... support congenital heart defect research by The Children,s ... and the general public are encouraged to download ... submit the completed artwork to the gallery on ...
(Date:9/1/2017)... N.J. , Sept. 1, 2017  Bayer will present ... the European Society for Medical Oncology (ESMO) 2017 Congress, September ... presented will include new preclinical and clinical data on Bayer,s ... two earlier pipeline projects. ... the best minds in cancer research at ESMO," said ...
(Date:8/28/2017)... 2017   Aesculight ®, a division of LightScalpel ®, LLC, ... Built on over 20 years of American veterinary laser surgery innovation, Aesculight® ... VetScalpel®Features and Enhancements ... excising a tumor with his new VetScalpel laser. Dr. Duclos practices veterinary ... ...
Breaking Medicine Technology: