Navigation Links
UT Southwestern study shows estrogen works in the brain to keep weight in check
Date:10/19/2011

DALLAS Oct. 20, 2011 A recent UT Southwestern Medical Center study found that estrogen regulates energy expenditure, appetite and body weight, while insufficient estrogen receptors in specific parts of the brain may lead to obesity.

"Estrogen has a profound effect on metabolism," said Dr. Deborah Clegg, associate professor of internal medicine and senior author of the study published Oct. 5 in Cell Metabolism. "We hadn't previously thought of sex hormones as being critical regulators of food intake and body weight."

The mouse study is the first to show that estrogen, acting through two hypothalamic neural centers in the brain, keeps female body weight in check by regulating hunger and energy expenditure. Female mice lacking estrogen receptor alpha a molecule that sends estrogen signals to neurons in those parts of the brain became obese and developed related diseases, such as diabetes and heart disease.

Similar results were not seen in male mice, although researchers suspect other unknown estrogen receptor sites in the brain play a similar role in regulating metabolism for males as well.

Estrogen receptors are located throughout the body, but researchers found two specific populations of estrogen receptors that appear to regulate energy balance for female mice.

The findings are potentially important for millions of postmenopausal women, many of whom have decided against hormonal replacement therapy. The study could lead to new hormonal replacement therapies in which estrogen is delivered to specific parts of the brain that regulate body weight, thereby avoiding the risks associated with full-body estrogen delivery, such as breast cancer and stroke.

Doctors stopped routinely recommending long-term estrogen therapy for menopausal women in 2002 when a Women's Health Initiative study showed the hormone also led to increased risk of cardiovascular disease.

"The role of estrogen in postmenopausal women continues to remain uncertain," Dr. Clegg said. "Current research is focused on the timing and the type of estrogen supplementation that would be most beneficial to women. Our findings further support a role for estrogens in regulating body weight and energy expenditure, suggesting a benefit of estrogen supplementation in postmenopausal women."


'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. UT Southwestern and University of Cape Town announce 5-year affiliation agreement
2. UT Southwestern, Parkland partner for $6.3 million NCI grant to improve colorectal cancer screenings
3. UT Southwestern scientist shares 2011 Nobel Prize in Physiology or Medicine
4. UT Southwestern launches hand transplant program
5. UT Southwestern support groups book reaches out to husbands, partners of women battling cancer
6. UT Southwestern ophthalmologist helps develop device for monitoring degenerative eye disease
7. UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
8. UT Southwestern pediatric urologist develops procedure to eliminate scarring in kidney surgeries
9. Drug shows improved kidney function for type 2 diabetics, UT Southwestern researchers report
10. UT Southwestern researchers uncover why ketamine produces a fast antidepressant response
11. UT Southwestern surgeons examine hypospadias repair efficacy for patients with differing anatomies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... 2016 , ... In a part of the city where’s it’s easy to spot the neon ... is hoping to attract diners with a taste for real food. , On ... doors to Cornerstone Grill, an urban casual restaurant focusing on dishes made by hand with ...
(Date:5/27/2016)... NJ (PRWEB) , ... May 27, 2016 , ... Two ... named as YWCA Tribute to Women and Industry (TWIN) 2016 honorees. The award ... their workplace. For this year, Geri Boone, Director of the MLTSS (Managed Long-Term Services ...
(Date:5/27/2016)... ... , ... With over 60 percent of acute stroke survivors being left unable ... aid in the rehabilitation process has steadily increased. Ekso Bionics had been working to ... to stroke. , Ekso Bionics has now received clearance from the U.S. Food and ...
(Date:5/27/2016)... York, NY (PRWEB) , ... May 27, 2016 ... ... partnered with Mediaplanet to help educate the many who are unaware of the ... dedicated to aphasia will run within the “Stroke Awareness” campaign. , The link ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... bolstered by inspiring human interest stories, which come courtesy of leaders in the nursing ... within the industry, from leading advocates and associations—namely Abilene Christian University. , As ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... , May 26, 2016   ... software and analytics, network solutions and technology-enabled ... announced it entered into a strategic channel ... of outpatient software solutions and revenue cycle ... specialty hospitals and rehabilitation clinics to optimize ...
(Date:5/25/2016)... -- FDA 510(k) clearance covers Confocal ... urological and surgical applications Mauna Kea ... the multidisciplinary confocal laser endomicroscopy (CLE) platform, today ... with the 12 th 510(k) clearance from ... new FDA clearance covers Confocal Miniprobes indicated for ...
(Date:5/25/2016)... , Deutschland und GERMANTOWN, Maryland ... Zusammenarbeit mit Therawis bedient ... bei Brustkrebs   QIAGEN N.V. (NASDAQ: ... gab heute bekannt, eine Lizenz- und Entwicklungsvereinbarung mit ... Assays für die Onkologie eingegangen zu sein. Ein ...
Breaking Medicine Technology: