Navigation Links
UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
Date:7/25/2011

DALLAS July 25, 2011 UT Southwestern Medical Center researchers have narrowed the potential drug targets for advanced prostate cancer by demonstrating that late-stage tumors are driven by a different hormonal pathway than was thought previously.

While testosterone is generally known to stimulate the growth of the disease, advanced prostate cancer that is resistant to standard hormonal therapy actually is driven by a pathway that circumvents the male hormone, said Dr. Nima Sharifi, assistant professor of internal medicine and senior author of the study in Proceedings of the National Academy of Sciences.

"Our findings will change the framework for the way people think about this disease," said Dr. Sharifi, a researcher in UT Southwestern's Harold C. Simmons Comprehensive Cancer Center. "The general assumption is that the tumor accelerates through testosterone when, in fact, the pathway goes around it to the most potent hormone. We both found the existence of this pathway in models and patients, and have shown that these resistant tumors are clearly driven by this other pathway."

Prostate cancer is the most common cancer in men and trails only lung cancer as a leading cause of cancer death for men in the U.S. Some 220,000 men are diagnosed with the disease every year; 32,000 will develop the metastasized form the focus of the current study and will die from it.

In advanced prostate cancer cases, the testosterone driving the disease is converted into a more potent hormone that accelerates tumor growth. The standard treatment has been to deplete testosterone in the tumors, but they eventually become resistant to hormone depletion because they make their own androgens, or male hormones.

In the current study, UT Southwestern scientists analyzed prostate cancer cell lines, mouse models and fresh tumor tissue from patients. Their findings suggest that potential drug therapies need to target an enzyme responsible for initiating hormone production earlier in the process.

"This now suggests that a potential drug target is one step upstream in the pathway," said Dr. Sharifi. "This can be thought of as charting a map of the correct pathway. You have to figure out which way the river flows before you can block the river."

The findings also will help researchers develop accurate biomarkers of response and resistance to hormonal therapies, which eventually will help identify why and how prostate cancer tumors become resistant, he said.


'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
2. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
3. UT Southwestern participates in nationwide study offering free lung tumor genetic testing
4. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
5. Novel anti-malarial drug candidate found by UT Southwestern researchers
6. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
7. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
8. UT Southwestern unveils next generation CT scanner that views whole organs in a heartbeat
9. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
10. Interferon might help asthma patients breathe easier, UT Southwestern study suggests
11. UT Southwesterns cancer center earns National Cancer Institute designation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 16, 2017 , ... In ... education and high-level training standards to an international multidisciplinary group of healthcare treatment ... As a way to further its mission at the grassroots level, iaedp launched ...
(Date:1/16/2017)... ... January 16, 2017 , ... NexTec Group has been selected as a ... honored for their accomplishments in the field of midmarket financial software. , Members of ... and innovation. Selection is not based on revenue and those firms chosen represent a ...
(Date:1/15/2017)... ... January 15, 2017 , ... Accreditation ... achieved accreditation for its specialty care services. Albertsons Companies is the largest ... care service for pharmacy patients. , Accreditation by ACHC reflects Albertsons Companies’ dedication ...
(Date:1/15/2017)... Pa. (PRWEB) , ... January 15, 2017 , ... The ... newest location in Radnor, Pennsylvania. As construction wraps up on the 14,000+ square foot ... The Gravity Vaults sixth location, including three in New Jersey and two in New ...
(Date:1/14/2017)... ... January 14, 2017 , ... AgileMinder develops innovative products and services that bring ... now available on Apple as a fun, free emoji sticker pack for iMessage. Use ... the ten color coded values on The Emoji Scale. , On Apple: "The ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... -- Research and Markets has announced the addition of ... their offering. ... Global multiple myeloma drugs market to grow at a CAGR of ... the present scenario and the growth prospects of the global multiple ... report considers the revenue generated from the sales of branded and ...
(Date:1/16/2017)... 16, 2017  This report by Persistence Market ... market for the period 2016–2024. The primary objective ... information related to market opportunities in the global ... study demonstrates the various dynamics that are expected ... of the global peripherally inserted central catheters market ...
(Date:1/16/2017)... 16, 2017 Derek H. Potts , ... was recently appointed Liaison Counsel in California,s ... Xarelto cases. In this role, Potts was assigned to ... actively assist the Court and Co Lead Plaintiff,s Counsel. ... Adelman Jackson Fairchild & Wade and Ruth ...
Breaking Medicine Technology: