Navigation Links
UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
Date:7/25/2011

DALLAS July 25, 2011 UT Southwestern Medical Center researchers have narrowed the potential drug targets for advanced prostate cancer by demonstrating that late-stage tumors are driven by a different hormonal pathway than was thought previously.

While testosterone is generally known to stimulate the growth of the disease, advanced prostate cancer that is resistant to standard hormonal therapy actually is driven by a pathway that circumvents the male hormone, said Dr. Nima Sharifi, assistant professor of internal medicine and senior author of the study in Proceedings of the National Academy of Sciences.

"Our findings will change the framework for the way people think about this disease," said Dr. Sharifi, a researcher in UT Southwestern's Harold C. Simmons Comprehensive Cancer Center. "The general assumption is that the tumor accelerates through testosterone when, in fact, the pathway goes around it to the most potent hormone. We both found the existence of this pathway in models and patients, and have shown that these resistant tumors are clearly driven by this other pathway."

Prostate cancer is the most common cancer in men and trails only lung cancer as a leading cause of cancer death for men in the U.S. Some 220,000 men are diagnosed with the disease every year; 32,000 will develop the metastasized form the focus of the current study and will die from it.

In advanced prostate cancer cases, the testosterone driving the disease is converted into a more potent hormone that accelerates tumor growth. The standard treatment has been to deplete testosterone in the tumors, but they eventually become resistant to hormone depletion because they make their own androgens, or male hormones.

In the current study, UT Southwestern scientists analyzed prostate cancer cell lines, mouse models and fresh tumor tissue from patients. Their findings suggest that potential drug therapies need to target an enzyme responsible for initiating hormone production earlier in the process.

"This now suggests that a potential drug target is one step upstream in the pathway," said Dr. Sharifi. "This can be thought of as charting a map of the correct pathway. You have to figure out which way the river flows before you can block the river."

The findings also will help researchers develop accurate biomarkers of response and resistance to hormonal therapies, which eventually will help identify why and how prostate cancer tumors become resistant, he said.


'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
2. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
3. UT Southwestern participates in nationwide study offering free lung tumor genetic testing
4. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
5. Novel anti-malarial drug candidate found by UT Southwestern researchers
6. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
7. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
8. UT Southwestern unveils next generation CT scanner that views whole organs in a heartbeat
9. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
10. Interferon might help asthma patients breathe easier, UT Southwestern study suggests
11. UT Southwesterns cancer center earns National Cancer Institute designation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... , ... March 29, 2017 ... ... Alliance (GRMA) is growing as it continues developing an ANSI-approved, consensus-based American ... The organization, which plans to publish the first ANSI-approved GMP standard for ...
(Date:3/29/2017)... , ... March 29, 2017 , ... HealthCareMandA.com will host ... April 20, 2017, at 1:00 PM ET. A recording of the webinar will also ... Webinar Series. , Home health and hospice companies are still popular targets for healthcare ...
(Date:3/29/2017)... ... March 29, 2017 , ... Physicians’ Education ... specialized continuing medical education conference for clinicians who manage some of the most ... York. , The program will be led by co- chairs Dr. John ...
(Date:3/28/2017)... ... March 28, 2017 , ... Tuesday, March 28, 2017, is the ... take the Diabetes Risk Test to find out if they are at risk for ... will light up the evening sky by programming the LAX pylons the color red. ...
(Date:3/28/2017)... ... March 28, 2017 , ... Revolution for Truth has organized ... protect parental rights and civil liberties, and to restore transparency within government agencies ... coincides with a press conference taking place Friday morning calling on President Trump ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 29, 2017   Dynatronics Corporation (NASDAQ: ... of Cynthia L. McHenry (Cyndi) as ... for leading Dynatronics manufacturing, distribution, and purchasing operations ... Dynatronics, CEO Kelvyn H. Cullimore, Jr. ... search process conducted by the company as it ...
(Date:3/29/2017)... , March 29, 2017 FinancialBuzz.com News Commentary  ... Data published in a research report ... will reach a value of USD 55.8 billion by 2025. The projection ... United States and a more open approach towards cannabis products ... Florida , North Dakota , ...
(Date:3/28/2017)... 2017 The global emerging cancer diagnostics market ... from 2016 to 2023 and reach a figure of ... is a chronic disease and is affecting a huge ... market. This report is focused on emerging cancer diagnostics ... is propelled due to factors such as: increasing number ...
Breaking Medicine Technology: