Navigation Links
UT Southwestern researchers uncover why ketamine produces a fast antidepressant response
Date:6/16/2011

DALLAS June 16, 2011 UT Southwestern Medical Center scientists are shedding new light on why the anesthetic drug ketamine produces a fast-acting antidepressant response in patients with treatment-resistant depression.

The drug's robust effect at low doses as a fast-acting antidepressant potentially has use in emergency rooms with high-risk patients.

"Ketamine produces a very sharp increase that immediately relieves depression," said Dr. Lisa Monteggia, associate professor of psychiatry at UT Southwestern and senior author of the study published June 15 in Nature.

Typical antidepressant medications one of the most widely prescribed classes of drugs in the U.S. each year often take several weeks to relieve symptoms of depression. If they are not successful within 12 weeks, physicians must prescribe a different antidepressant to produce a response.

"Ketamine produces a fast-acting antidepressant effect, and we hope our investigation provides critical information to treat depression effectively sooner," Dr. Monteggia said.

"We now have a novel pathway to explore that may provide potential for the development of faster-acting and longer-lasting antidepressants," Dr. Monteggia said.

The next step, Dr. Monteggia said, is to investigate further the short- and long-term effects of the changes that occur when the brain cells communicate with each other.


'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. UT Southwestern surgeons examine hypospadias repair efficacy for patients with differing anatomies
2. UT Southwestern research uncovers genetic link between emphysema, lung cancer
3. UT Southwestern research teams anti-malarial work wins international Project of the Year award
4. Drug can reverse overgrown hearts to help prevent heart failure, UT Southwestern researchers find
5. UT Southwesterns Luis Parada elected to National Academy of Sciences
6. Antidepressants may not improve all symptoms of depression, UT Southwestern researchers find
7. Limiting carbs, not calories, reduces liver fat faster, UT Southwestern researchers find
8. Pelvic-repair device developed by UT Southwestern surgeons enables minimally invasive trauma surgery
9. UT Southwestern pediatricians launch landmark childrens health study
10. Grant helps UT Southwestern researcher study causes of preterm birth
11. Dangerous blood pressure increases during exercise can be blocked, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , ... June 30, 2015 , ... The American Lung ... at a media event in San Diego. Speakers and clean air advocates included San ... medicine, Natalie Germuska of Kindred Hospital, and Daniel Sullivan, founder and president of Sullivan ...
(Date:6/30/2015)... ... June 30, 2015 , ... According to a June 15th ... grant to study how sensory stimuli can be used to “decrease children’s anxiety and ... for children with autism, will compare patient experience in a “typical dental environment” with ...
(Date:6/30/2015)... NY (PRWEB) , ... June 30, 2015 , ... ... when buying eyeglasses online , finally its here, http://www.express-glasses.com ... express shipping rates, for many location, ask about shipping with DHL Express when ...
(Date:6/30/2015)... ... June 30, 2015 , ... Rocky Mountain Oils, a leading non-MLM supplier ... added a new CEO, Mr. Darold Francis. The changes will help enhance the company’s ... that customers have come to know and respect for over eight years. , “I ...
(Date:6/30/2015)... ... June 30, 2015 , ... MJH Associates today ... Healthcare Research & Analytics , a consultative healthcare market research practice that is ... businesses. HRA offers quantitative and qualitative, custom and multi-client primary market research services ...
Breaking Medicine News(10 mins):Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 2Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 3Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 2Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 3Health News:Eyeglasses Online - Express Glasses Announcing New International Shipping Using DHL 2Health News:Rocky Mountain Oils Adds New CEO, Announces Relocation of Operations to Orem, Utah 2Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 2Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 3
... public, even families are involved, study finds , FRIDAY, ... family history of an incurable genetic disease isn,t worry ... report being discriminated against by insurance companies, relatives and ... Yvonne Bombard and colleagues at the University of British ...
... Children,s Hospital, Summit County ... to provide full-range of services to families with children who have ... Copley Township , , FAIRLAWN, Ohio, ... creation of the Robert J. Keegan Family Center for Autism. , , ...
... Denmark, Friday 12 June 2009: First line treatment with ... ,good, clinical response (ACRp90) in patients newly diagnosed with ... deficient IL-18 response of natural killer (NK) cells*, according ... a joint congress with the 2009 Congress of the ...
... June 2009: Three new studies have individually shown the ... with a good safety profile, in children under four ... associated with improved Health-Related Quality of Life (HRQoL) in ... are being presented at the Paediatric Rheumatology European Society ...
... Denmark, Friday 12 June 2009: Over half (56%) of ... chronic inflammatory disease of the gum and surrounding ligaments ... fewer teeth than healthy matched controls, high prevalence of ... (the extent of periodontal support that has been destroyed ...
... frailty stand to benefit from the first potential ... study presented today by Penn Medicine researchers at ... Ghrelin, a hormone that stimulates appetite, was administered ... geriatric syndrome characterized by unintentional weight loss, weakness, ...
Cached Medicine News:Health News:People With Huntington's Report Discrimination 2Health News:People With Huntington's Report Discrimination 3Health News:Autism Family Foundation Introduces The Robert J. Keegan Family Center for Autism 2Health News:Autism Family Foundation Introduces The Robert J. Keegan Family Center for Autism 3Health News:Early treatment of systemic onset JIA with anakinra restores the IL-18 response 2Health News:3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis 2Health News:3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis 3Health News:3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis 4Health News:Over half of people with rheumatoid arthritis have periodontitis 2Health News:Over half of people with rheumatoid arthritis have periodontitis 3Health News:Appetite-stimulating hormone is first potential medical treatment for frailty in older women 2
(Date:6/30/2015)... June 30, 2015  July 4 th is this ... and the spirit and people behind it. To help honor ... with USA Medical Card, a leading ... for programs that empower independence for our disabled military veterans, ... more people afford their prescriptions. "Due to ...
(Date:6/30/2015)... 2015  Egalet Corporation (Nasdaq: EGLT ... company focused on developing, manufacturing and marketing ... from a Category 3 human abuse liability ... oral oxycodone product candidate in late-stage clinical ... enough to require daily, around-the-clock opioid treatment ...
(Date:6/29/2015)... -- Mordor Intelligence presents their Global Pharmaceutical ... Glass, Paper, Metal) - ByType of Packaging (Ampules, Blister Packs, ... Sachets) - By Geographical Region ( North America ... , Latin America , ... - discussing Industry Value Chain Analysis, Porter,s 5 Force Analysis, ...
Breaking Medicine Technology:Hope For Heroes and USA Medical Card Make a Difference for Our Nation's Heroes 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 3Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 4Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 5Global Pharmaceutical Packaging Market - North America and Europe Expected to Lead Followed by the Asia Pacific Market 2Global Pharmaceutical Packaging Market - North America and Europe Expected to Lead Followed by the Asia Pacific Market 3
... , GREENSBORO, N.C. , Feb. 17 ... feel insecure and self-conscious. Approximately 90% of pregnant women and 70% ... in people who have lost weight within a brief time period. ... body image issues for women of all shapes and sizes. With ...
... SANTA ROSA, Calif. , Feb. 16 Osseon Therapeutics ... Europe . The procedures were performed in Milan, Italy ... largest independent medical device distributor in Europe , Osseoplasty cases ... United Kingdom , Germany and Spain . ...
Cached Medicine Technology:Merz Pharmaceuticals Introduces New Mederma(R) Stretch Marks Therapy Now Available in Drugstores Nationwide 2Merz Pharmaceuticals Introduces New Mederma(R) Stretch Marks Therapy Now Available in Drugstores Nationwide 3Osseon Launches in Europe 2
... The MicroAire® Hi Speed Pulse Lavage ... bone surfaces as well as cleansing ... Now a great system just got ... effective with the addition of ...
... Staple is a novel shape memory alloy bone ... of its Nitinol construction, the prongs of the ... upon application of a heating current. This results ... response of bone and cause adjustable compression across ...
... deformity of the ankle joint with ... fusion of the ankle joint, fractures ... where reconstruction is impossible, and fracture/dislocations ... severe arthritic changes and loss of ...
The Buechel-pappas™ Total Ankle Replacement is a time-tested system which is the result of more than twenty years of development, clinical investigation, and use. The components have been avai...
Medicine Products: