Navigation Links
UT Southwestern researchers launch study into search-and-destroy antigen for deadly skin cancer
Date:8/10/2009

DALLAS Aug. 10, 2009 UT Southwestern Medical Center researchers are studying a new antigen to see whether it can track down and kill cancer cells in patients with recurring melanoma, the leading cause of skin cancer deaths.

Researchers are testing a tumor-specific protein called recombinant human melanoma antigen A3 (MAGE-A3) that researchers hope will interact with the body's immune system and generate a search-and-destroy program targeting deadly melanoma cells.

"We inject this antigen into the person and hopefully their immune system will respond to the protein, creating antibodies and cells that will kill the tumor cells. Then, they go through the body to kill cancer cells wherever they reside," explained Dr. James Huth, professor of surgery at UT Southwestern. "It's an old concept, but now we're keying on a specific antigen."

Researchers have been looking for proteins found exclusively in melanoma cells and not in normal human cells so that they can then direct the immune system to generate antibodies that kill only cells containing that specific protein. Earlier studies flagged the MAGE-A3 protein, which resides on the top of certain cancerous cells but is not expressed in normal cells, as a possible target for treating melanoma as well as certain lung, head-and-neck and bladder cancers.

UT Southwestern is one of about 50 sites nationally that will participate in the trial and is actively recruiting patients who have melanoma that has also affected lymph nodes. Participants will be tracked over a five-year period after receiving a series of injections.

"We'd be interested in talking to anyone who has melanoma that has spread to their lymph nodes," Dr. Huth said. "MAGE-A3 had some responses in some melanoma patients in phase 1 and phase 2 studies, and so now we want to see in this phase 3 if something happens in a larger population."

One in every three cancers diagnosed in the U.S. is a skin cancer an
'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dysport proves safe, effective anti-wrinkle treatment, UT Southwestern plastic surgeons find
2. Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report
3. UT Southwestern, UT Arlington to develop magnetic surgery tools
4. UT Southwestern researcher named HHMI Early Career Physician-Scientist
5. Former Gov. Bill Clements Makes Historic Gift to UT Southwestern With $100 Million Transformative Contribution
6. UT Southwesterns Olson wins prestigious French award for heart research
7. Participants in antidepressant drug trials are atypical patients, UT Southwestern researchers report
8. UT Southwestern University Hospital earns outstanding achievement award for cancer care
9. UT Southwestern researchers reveal how the brain processes important information
10. UT Southwestern teaching hospital halves its rate of premature births, researchers find
11. Burn rehabilitation experts at UT Southwestern outline best treatments for post-burn itching
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Calif. (PRWEB) August 30, 2014 Insomnia causes ... helps listeners understand how they unknowingly developed insomnia and the ... restful nights during. Tune in to the show at ... The show airs live on August 30, and will be ... information on programming, go to DrCarolFrancisTalkRadio.com. , "Insomnia ...
(Date:8/30/2014)... Randy Dotinga HealthDay ... About one in five patients operated on for broken bones ... surgery, a new study finds. Less-educated patients and ... more likely to be "doctor shoppers," said study lead author ... Ky. Overall, he said, the study suggests that doctors aren,t ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Hastings and ... injury attorneys located throughout Arizona is pleased to report ... is one specific example among many cases where Hastings ... are able to retain a greater portion of their ... case that providing a positive solution for Arizona car ...
(Date:8/30/2014)... Administration of colchicine, a plant-based medication commonly used ... showed mixed results in reducing potential complications from ... the risk of gastrointestinal adverse effects, according to ... study is being released early online to coincide ... Cardiology Congress. , Common complications after cardiac surgery ...
(Date:8/30/2014)... 2014 "My niece developed a nighttime ... any moment, her fever might get worse," said an ... well aware of how she was doing, I developed ... to continuously monitor a child's temperature. The unit instantly ... ensures that prompt medical care can be given, which ...
Breaking Medicine News(10 mins):Health News:Sleepless Nights, Exhausting Days, Mental Fog – Relief for Insomnia With Clinical Psychologist Dr. Carol Francis 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 3Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $67,100 On A Settlement Of $610,000 2Health News:Medication shows mixed results in reducing complications from cardiac surgery 2
... closely watching the developments in a little-known southwestern Ontario ... vaccine-related exposure among its members. // ,This ... the United States. Health officials are not disclosing the ... thought to be in close vicinity of the Middlesex ...
... is on track to roll-out a nationwide screening programme ... infertility in both sexes//. ,So far nearly 80,000 ... difficult to detect but is easy to cure, following ... Programme (NCSP). ,There has been a heightened concern ...
... is a very famous saying which refers to an attitude ... achieve it and so feign that we are not concerned ... Everybody knows it's good; yet many people still avoid it, ... above statement researchers at the University of Illinois at Urbana-Champaign ...
... As per a Goldman Sachs report, bird flu may reduce ... is easily transmitted among humans, possibly by more than 1-million ... barrels a day, according to data issued by the US ... true global pandemic, the economic implications would be profound, potentially ...
... The FDA has sent shock waves in the industry ... Nov. 8 from the U.S. Food and Drug Administration ... for qualified health claims for lycopene, tomatoes, and tomatoes-based ... lycopene (tomatoes, tomato-based foods containing lycopene) may reduce the ...
... found that less volume of white matter in the frontal lobe ... of decline in brain activity//. The researchers have found that the ... related but due to not using the white matter (frontal lobe) ... the left side of the brain which contains the Grey matter ...
Cached Medicine News:Health News:UK Govt Says On Course For National Chlamydia Screening 2Health News:Important parameters of life: Longevity and quality: both improved by exercise 2Health News:Important parameters of life: Longevity and quality: both improved by exercise 3Health News:Bird Flu Likely To Reduce World Energy Demand 2
(Date:8/29/2014)... DIEGO , Aug. 29, 2014   ... emerging biopharmaceutical company, announced today that Santosh Vetticaden, ... be leaving the Company, for personal reasons, in ... Chief Medical Officer of Aires Pharmaceuticals, which Mast ... former responsibilities as the Company,s interim Chief Medical ...
(Date:8/29/2014)... Research and Markets has announced ... Market & Pipeline Insight 2014" report to their ... prevent and eradicate the prevalence of cancer have achieved ... to low specificity, safety and large number of side ... better solution. It has been discovered that peptides can ...
(Date:8/29/2014)... SILVER SPRING, Md. , Aug. 29, 2014 /PRNewswire/ ... today that the U.S. District Court for the District ... in its favor in the company,s case against Sandoz, ... opinion, Judge Peter Sheridan ruled that U.S. ... Sandoz, Inc., and enjoined Sandoz from marketing its generic ...
Breaking Medicine Technology:Mast Therapeutics Announces Management Change 2Mast Therapeutics Announces Management Change 3Mast Therapeutics Announces Management Change 4Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2District Court Decision Received In Remodulin Patent Case 2
... are part of the Freedom Urinary ... leg bags, kits, and accessories designed ... our customers. These leg bags are ... of 100% latex-free soft, textured medical ...
... bags are part of the Freedom ... of leg bags, kits, and accessories ... of our customers. These leg bags ... constructed of 100% latex-free soft, textured ...
... are part of the Freedom Urinary ... leg bags, kits, and accessories designed ... our customers. These leg bags are ... of 100% latex-free soft, textured medical ...
The latex-free, PVC-free Antibacterial Hydro Personal catheter combines two remarkable innovations into one exclusive catheter that delivers an antibacterial agent while providing the virtually frict...
Medicine Products: