Navigation Links
UT Southwestern researchers investigate predictors for sickle-cell-anemia complications
Date:2/28/2008

DALLAS Feb. 29, 2008 Researchers at UT Southwestern Medical Center have determined that the level, or saturation, of oxygen in blood could be used to identify children with sickle cell anemia who are at an increased risk of stroke.

In a related study, they have also found that a published method used to predict severe complications of the disease may not be adequate.

Stroke is a serious but increasingly preventable complication of sickle cell disease, said Dr. Charles Quinn, assistant professor of pediatrics at UT Southwestern and lead author of a study appearing in Februarys British Journal of Haematology. Several factors have been identified that increase risk for stroke, but better screening tools are still needed.

Hemoglobin is an oxygen-transport protein in red blood cells. People with sickle cell disease, including an estimated 100,000 Americans, have a genetic error affecting their hemoglobin. The defect turns normally soft, round blood cells into inflexible, sickle-shaped cells. The altered shape causes blockages in blood vessels and prevents body tissues from receiving oxygen.

The researchers reviewed the cases of 412 children who are part of the Dallas Newborn Cohort, the worlds largest group of patients with sickle cell disease who were initially diagnosed by newborn screening. All patients reviewed were born after Jan. 1, 1990, a date chosen because patient data was available electronically.

Oxygen saturation in the childrens blood was tracked over time, and the records of those who suffered a stroke were compared to those who did not. The children who had lower levels of oxygen in their blood were more likely to develop stroke, the researchers found.

A decline in oxygen saturation over time seems to further increase the risk of stroke, said Dr. Quinn. Oxygen saturation is easily measured, potentially modifiable and might be used to identify children with sickle cell disease who are at greater risk of having a stroke.

Another study by Dr. Quinn and his colleagues appeared in the January issue of the journal Blood. That study examined how effectively a model developed by the Cooperative Study of Sickle Cell Disease (CSSCD) predicted severe disease in the newborn cohort.

Because sickle cell disease can affect children in many different ways, it is difficult to identify young children who are at high risk of adverse outcomes before irreversible organ damage occurs. Such outcomes include death, stroke, frequent pain or recurrent acute chest syndrome. The CSSCD criteria, which evaluates patients based on factors such as occurrences of dactylitis a type of painful swelling of the hands and feet in the first year of life, steady-state hemoglobin concentration in the second year of life, and steady-state leukocyte count in the second year of life, was created in hopes that a predictive model would allow early, tailored therapy to prevent adverse outcomes.

We found the CSSCD model was not better than random prediction when applied to the Dallas Newborn Cohort, said Dr. Quinn, the Blood studys lead author. Most subjects who experienced adverse events were predicted to be at low risk for adverse events, and no subject who was predicted to be at high risk actually experienced an adverse outcome. We concluded that the model was not clinically useful, at least not in the Dallas cohort.

Dr. Quinn said the findings suggest that the CSSCD model should not be used as the sole criterion to initiate early, high-risk intervention and that a robust early prediction model is still needed.


'/>"/>

Contact: Erin Prather Stafford
erin.pratherstafford@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. UT Southwestern surgeons complete North Texas first single-incision gallbladder removal
2. UT Southwestern plastic surgeons deploy new carbon dioxide-based fractional laser
3. BMI criteria for obesity surgery should be lowered, UT Southwestern researchers suggest
4. UT Southwestern: Patients with mild Cushing syndrome may benefit from adrenalectomy
5. Physicians seek to improve the quality of sleep in ICU, researchers at UT Southwestern report
6. UT Southwestern urologist uses Botox to treat debilitating condition
7. UT Southwestern researcher named Howard Hughes Medical Institute investigator
8. 2 UT Southwestern researchers elected to National Academy of Sciences Institute of Medicine
9. UT Southwestern investigating hypothermic technique in treating pediatric head injuries
10. UT Southwestern scientist receives NIH Directors New Innovator Award
11. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern researchers investigate predictors for sickle-cell-anemia complications
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... Engineers at ... bio-compatible, because it produces the same kind of electrical energy that the body uses. ... form of moving electrons. This flow of electrons out of the battery is generated ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... federal Substance Abuse and Mental Health Services Administration’s (SAMHSA) State Targeted Response to ... Department of Health Care Services, will facilitate the development of a hub and ...
(Date:7/24/2017)... ... July 24, 2017 , ... Every year, thousands of dedicated Higher ... InstructureCon. Each annual event is coupled with a dynamic theme like Camp Canvas; this ... theme, Mission: InstructureCon 0017. , To extend their partnership with Canvas beyond the ...
(Date:7/24/2017)... Beach, California (PRWEB) , ... July 24, 2017 ... ... commercialization of autologous fat (adipose) transfer systems announces the issuance of United States ... ‘324 patent) for its adipose filtration technology. The '398 and '324 patents ...
(Date:7/24/2017)... ... July 24, 2017 , ... Paul Vitenas, MD, FACS is excited to report ... invited to attend Allergan’s recent meeting with their Plastics Advisory Board. As one of ... Allergan is bringing a newly defined structure to the aesthetics market. Dr. Vitenas ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... 17, 2017  MedX Holdings, Inc., the manufacturer and ... and rehabilitation equipment, today announced the national roll out ... considered the gold standard for the treatment of low ... strengthening equipment. How ... physician or practice who prescribe the MedX Home Back ...
(Date:7/13/2017)... 13, 2017  Centurion Medical Products, a leader in medical product ... fecal impaction removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are part ... alleviate patient pain while preventing unneeded emergency department admission due to ...
(Date:7/12/2017)... INDIANAPOLIS , July 12, 2017  Eli Lilly and ... settlement agreement with generic companies to resolve pending patent litigation ... Virginia regarding the Cialis ® ... expire on April 26, 2020. As part of the agreement, ... on September 27, 2018. "The unit dose patent ...
Breaking Medicine Technology: