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UT Southwestern researchers identify protein that may explain 'healthy' obesity
Date:1/29/2009

thout becoming inflamed, suggesting that collagen VI directly affects the ability of fat cells to expand."

Dr. Scherer said the current finding is clinically relevant and probably will translate well from the mice to humans. "Our study highlights the fact that collagen VI, and possibly other extracellular matrix constituents, are extremely important in modulating fat-cell physiology," he said.

The next step is to determine precisely how collagen VI functions in the body.

"We need to get a better grip on targets that may allow us to interfere in this process. Unfortunately collagen VI can't be knocked out in humans, but we may be able to manipulate it," Dr. Scherer said.


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Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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