Navigation Links
UT Southwestern researchers identify protein that may explain 'healthy' obesity
Date:1/29/2009

DALLAS Jan. 29, 2009 Mice whose fat cells were allowed to grow larger than fat cells in normal mice developed "healthy" obesity when fed a high-fat diet, researchers at UT Southwestern Medical Center found in a new study.

The fat but healthy mice lacked a protein called collagen VI, which normally surrounds fat cells and limits how large they can grow, like a cage around a water balloon. The findings appear online and in a future edition of Molecular and Cellular Biology.

"The mice lacking collagen VI fared much better metabolically than their counterparts that retained this particular collagen," said Dr. Philipp Scherer, director of the Touchstone Center for Diabetes Research at UT Southwestern and the study's senior author. "The mice without collagen VI don't develop inflammation or insulin resistance. They still get obese, but it's a 'healthy' obesity."

When people take in more calories than needed, excess calories are stored in adipose or fatty tissue. The fat cells are embedded in and secrete substances into an extracellular matrix, a type of connective tissue that provides support to fat tissue, like scaffolding. Collagen VI is one component of the extracellular matrix. Too much of this connective tissue prevents individual cells from expanding and can lead to fibrosis and eventually inflammation.

Inflammation is thought to be an underlying cause of metabolic disorders in humans, said Dr. Scherer. Large fat cells are often considered a bad omen, he said, because they typically lead to increased cell death and systemic insulin resistance. Under normal circumstances, fat cells continue to grow until they reach a point where the extracellular matrix they've built around themselves is so strong that it's no longer flexible.

"In this particular case, however, the large fat cells are not as inflamed as they would normally be," Dr. Scherer said. "Fat cells that lack collagen VI can grow to a huge size without becoming inflamed, suggesting that collagen VI directly affects the ability of fat cells to expand."

Dr. Scherer said the current finding is clinically relevant and probably will translate well from the mice to humans. "Our study highlights the fact that collagen VI, and possibly other extracellular matrix constituents, are extremely important in modulating fat-cell physiology," he said.

The next step is to determine precisely how collagen VI functions in the body.

"We need to get a better grip on targets that may allow us to interfere in this process. Unfortunately collagen VI can't be knocked out in humans, but we may be able to manipulate it," Dr. Scherer said.


'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. UT Southwestern researchers discover brains memory buffer in single cells
2. UT Southwestern researchers find drug-coated stents less risky for heart bypass patients
3. UT Southwestern University Hospitals transplant program recognized for increasing organ donor rates
4. Childhood anxiety disorders can and should be treated, according to UT Southwestern national expert
5. Interferon needed for cells to remember how to defeat a virus, UT Southwestern researchers report
6. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
7. Cancer requires support from immune system to develop, UT Southwestern researchers report
8. Vaginal/Caesarean combo delivery of twins safe, UT Southwestern-led research finds
9. Steroids aid recovery from pneumonia, UT Southwestern researchers say
10. Superbug breast infections controllable in nursing mothers, UT Southwestern researchers find
11. UT Southwestern scientists discover leptin can also aid type 1 diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
Breaking Medicine Technology: