Navigation Links
UT Southwestern researchers identify protein that may explain 'healthy' obesity
Date:1/29/2009

DALLAS Jan. 29, 2009 Mice whose fat cells were allowed to grow larger than fat cells in normal mice developed "healthy" obesity when fed a high-fat diet, researchers at UT Southwestern Medical Center found in a new study.

The fat but healthy mice lacked a protein called collagen VI, which normally surrounds fat cells and limits how large they can grow, like a cage around a water balloon. The findings appear online and in a future edition of Molecular and Cellular Biology.

"The mice lacking collagen VI fared much better metabolically than their counterparts that retained this particular collagen," said Dr. Philipp Scherer, director of the Touchstone Center for Diabetes Research at UT Southwestern and the study's senior author. "The mice without collagen VI don't develop inflammation or insulin resistance. They still get obese, but it's a 'healthy' obesity."

When people take in more calories than needed, excess calories are stored in adipose or fatty tissue. The fat cells are embedded in and secrete substances into an extracellular matrix, a type of connective tissue that provides support to fat tissue, like scaffolding. Collagen VI is one component of the extracellular matrix. Too much of this connective tissue prevents individual cells from expanding and can lead to fibrosis and eventually inflammation.

Inflammation is thought to be an underlying cause of metabolic disorders in humans, said Dr. Scherer. Large fat cells are often considered a bad omen, he said, because they typically lead to increased cell death and systemic insulin resistance. Under normal circumstances, fat cells continue to grow until they reach a point where the extracellular matrix they've built around themselves is so strong that it's no longer flexible.

"In this particular case, however, the large fat cells are not as inflamed as they would normally be," Dr. Scherer said. "Fat cells that lack collagen VI can grow to a huge size wi
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UT Southwestern researchers discover brains memory buffer in single cells
2. UT Southwestern researchers find drug-coated stents less risky for heart bypass patients
3. UT Southwestern University Hospitals transplant program recognized for increasing organ donor rates
4. Childhood anxiety disorders can and should be treated, according to UT Southwestern national expert
5. Interferon needed for cells to remember how to defeat a virus, UT Southwestern researchers report
6. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
7. Cancer requires support from immune system to develop, UT Southwestern researchers report
8. Vaginal/Caesarean combo delivery of twins safe, UT Southwestern-led research finds
9. Steroids aid recovery from pneumonia, UT Southwestern researchers say
10. Superbug breast infections controllable in nursing mothers, UT Southwestern researchers find
11. UT Southwestern scientists discover leptin can also aid type 1 diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... Plains, NJ (PRWEB) , ... August 31, 2015 , ... ... as an “NJ Top Doc.” , At OSSMC, Dr. Kovatis treats all surgical and ... orthopedics and traumatic injuries to the entire musculoskeletal system, excluding the spine. , Dr. ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... digital marketing communications company announced today that it has officially launched a new ... the new website and brand refresh are more closely aligned with the company’s ...
(Date:8/31/2015)... ... August 31, 2015 , ... Finnleo is pleased to announce ... Sauna. After months of extensive engineering and design of our newest sauna model, the ... elements and is offered at a very attractive price-point. , Before outdoor saunas ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... ezDI’s computer-assisted coding (CAC) software for its Clinical Documentation Improvement (CDI) and medical ... a patent pending ICD-10 solution - ezCAC is an enterprise-level coding solution that ...
(Date:8/31/2015)... Valley, CA (PRWEB) , ... August 31, 2015 , ... ... Ghasri, to the practice. Dr. Pedram Ghasri is a graduate of the University of ... neuroscience and continued his studies at the University of California, Irvine Medical School. As ...
Breaking Medicine News(10 mins):Health News:NJ Top Docs Presents, Dr. Paul Kovatis of Orthopedic Spine & Sports Medicine Center on his Five Year Anniversary as an "NJ Top Doc" 2Health News:Diablo Publications Launches New Company Website 2Health News:Diablo Publications Launches New Company Website 3Health News:Say “Hello” to the Brand New Finnleo Terrace Outdoor Saunas 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 3Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 4Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2
... of outdated inspection practices desperately needed, critics say ... system that guarantees the safety of food in the ... new report finds. , Gaps in the food safety ... inconsistencies among agencies protecting food safety, according to the ...
... have a significantly higher risk of developing Alzheimers ... remains unexplained. Now, researchers at the Salk Institute ... for the diabetes Alzheimers interaction. , In ... of Neurobiology of Aging, investigators led by David ...
... becoming three kinds of cardiac cells , , WEDNESDAY, April ... created from mouse skin cells reprogrammed to have the ... researchers at the University of California, Los Angeles. ... induced pluripotent stem (iPS) cells, which don,t involve the ...
... Actually Work in Real ... ... healthcare community, announced the launch of an,innovative new tool that brings patient ... drugs, and eight out of,ten surfing the web for their healthcare information, ...
... lifestyles, WASHINGTON, April 29 Blue Cross ... of all sizes to get,their workers to take ... inactive lifestyles and preventable health conditions,have on the ... companies,are holding lunchtime walks across America as part ...
... Inc.,(NYSE: HI ) today announced that its Board ... traded company of $0.1825 per share,on the company,s common ... of record at the close of business on June ... approve this inaugural dividend is based,on the strength of ...
Cached Medicine News:Health News:Report Slams U.S. Food Safety System 2Health News:Report Slams U.S. Food Safety System 3Health News:Report Slams U.S. Food Safety System 4Health News:Salk study links diabetes and Alzheimer's disease 2Health News:Salk study links diabetes and Alzheimer's disease 3Health News:Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells 2Health News:iGuard.org Alters the Face of E-Health: New Web Service Draws 10,000 New Patients Weekly 2Health News:iGuard.org Alters the Face of E-Health: New Web Service Draws 10,000 New Patients Weekly 3Health News:Blue Cross and Blue Shield Companies to Get Workers Out of The Office and on Their Feet in All 50 States 2Health News:Blue Cross and Blue Shield Companies to Get Workers Out of The Office and on Their Feet in All 50 States 3Health News:Blue Cross and Blue Shield Companies to Get Workers Out of The Office and on Their Feet in All 50 States 4Health News:Blue Cross and Blue Shield Companies to Get Workers Out of The Office and on Their Feet in All 50 States 5Health News:Hillenbrand, Inc. Declares First Quarterly Dividend As a New Publicly Traded Company 2
(Date:8/31/2015)... , Aug. 31, 2015  Daktari Diagnostics today announced a ... United States and Canada , ... The deal, worth up to $8.5 million over the next ... clinical validation and regulatory approval of Daktari,s HCV test. ... point-of-care instrument that can detect low levels of virus directly ...
(Date:8/31/2015)... Aug. 31, 2015  On August 5, 2015, the ... Oregon denied motions to dismiss securities class ... ) and certain of its directors. The class actions ... and dump" scheme to artificially inflate Galena,s stock price, ... stock price was inflated, sold massive amounts of their ...
(Date:8/31/2015)... -- Regen BioPharma, Inc. (OTCBB: RGBP) and (PINK: ... of delivering its patented (US Patent 8,263,571) gene ... a clinically approved formulation as delivery system.  The ... silencing therapeutics in which the gene silencing drug ... By utilizing a local delivery system, potential toxicities ...
Breaking Medicine Technology:Daktari Enters Collaboration Agreement with Merck to Develop Test for Hepatitis C Virus 2Daktari Enters Collaboration Agreement with Merck to Develop Test for Hepatitis C Virus 3Galena Biopharma, Inc. Stock Alert: Schubert Firm Investigates Potential Breaches of Fiduciary Duty 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3
... FREDERICKSBURG, Va., Feb. 17, 2011 Radiologic Associates ... Gently Campaign to increase awareness of opportunities to lower ... initiative of the Alliance for Radiation Safety in Pediatric ... undergone additional training in ways to reduce radiation exposure, ...
... Feb. 17, 2011 The method represented in the ... respiratory arterial pressure wave (a blood wave that ... blood pressure readings to provide healthcare professionals and users ... on systemic blood pressure. (Logo: ...
Cached Medicine Technology:Radiologic Associates of Fredericksburg Announces Image Gently Campaign to 'Child Size' Doses for Children 2ICAP Ocean Tomo Announces Advanced Techniques for Measuring Blood Pressure From Coherence L.L.C. 2
Distinct male and female designs for proper anatomical fit. Hip and pelvic components sized independently. Rigid posterior tongue minimizes pelvic rotation. Available in black or white plastic. Aggre...
... B3 Triplanar hip joint is ... - extension, abduction - Ad-duction, ... our Boston Post-Op Hip Orthosis. ... custom Hip Spicas in both ...
... advance in walker design in years. A real step ... bearing surfaces of the foot rest on adaptive areas ... heel strike. The footbed in the sole conforms to ... and stability. , ,No leg length discrepancy; Heel ...
... The High Tide walker provides comfortable stability ... of the lower leg, stress fractures of ... fractures of the ankle. Extension pads for ... patients.The shorter Low Tide walker with midcalf ...
Medicine Products: