Navigation Links
UT Southwestern researchers create experimental vaccine against Alzheimer's
Date:10/8/2010

DALLAS Oct. 12, 2010 Researchers at UT Southwestern Medical Center have created an experimental vaccine against beta-amyloid, the small protein that forms plaques in the brain and is believed to contribute to the development of Alzheimer's disease.

Compared with similar so-called DNA vaccines that the UT Southwestern researchers tested in an animal study, the new experimental vaccine stimulated more than 10 times as many antibodies that bind to and eliminate beta-amyloid. The results appeared in the journal Vaccine.

Future studies will focus on determining the safety of the vaccine and whether it protects mental function in animals, said Dr. Roger Rosenberg, director of the Alzheimer's Disease Center at UT Southwestern and senior author of the study.

"The antibody is specific; it binds to plaque in the brain. It doesn't bind to brain tissue that does not contain plaque," Dr. Rosenberg said. "This approach shows promise in generating enough antibodies to be useful clinically in treating patients."

A traditional vaccine an injection of beta-amyloid protein itself into the arm has been shown in other research to trigger an immune response, including the production of antibodies and other bodily defenses against beta-amyloid. However, the immune response to this type of vaccine sometimes caused significant brain swelling, so Dr. Rosenberg and his colleagues focused on developing a nontraditional DNA vaccine.

The DNA vaccine does not contain beta-amyloid itself but instead a piece of the beta-amyloid gene that codes for the protein. In the current study, the researchers coated tiny gold beads with the beta-amyloid DNA and injected them into the skin of the animals' ears. Once in the body, the DNA stimulated an immune response, including antibodies to beta-amyloid.

The next step in the research is to test long-term safety in animals, Dr. Rosenberg said.

"After seven years developing this vaccine, we are hopeful it will not show any significant toxicity, and that we will be able to develop it for human use," he said.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Blood test could diagnose Alzheimers disease, UT Southwestern researchers find
2. NIH awards $8 million to UT Southwestern to study metabolism, obesity-related inflammation
3. Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
4. UT Southwestern University Hospital -- St. Paul recognized as Primary Stroke Center
5. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
6. Chemical system in brain behaves differently in cocaine addicts, UT Southwestern scientists find
7. UT Southwesterns cancer center earns National Cancer Institute designation
8. Interferon might help asthma patients breathe easier, UT Southwestern study suggests
9. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
10. UT Southwestern unveils next generation CT scanner that views whole organs in a heartbeat
11. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the ... as Vice President of North American Capital Sales at HTG Molecular . ... team in the commercialization of the HTG EdgeSeq system and associated reagents in North ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
Breaking Medicine Technology: