Navigation Links
UT Southwestern research uncovers genetic link between emphysema, lung cancer
Date:6/8/2011

DALLAS June 9, 2011 A gene linked to emphysema also can be a factor for developing lung cancer unrelated to cigarette smoking, UT Southwestern Medical Center research indicates. Smoking was the only known risk factor previously associated with both diseases.

In the study, mice bred to have the human gene pleiomorphic adenoma gene-like 2 (PLAGL2) all developed emphysema, and by gender also developed lung cancer at rates as high as one in every six rodents. Although the new study showed PLAGL2 as a contributing factor in emphysema and lung cancer development, the diseases form in opposite ways. Emphysema arises from cell death or injury, while lung cancer involves uncontrolled cell growth.

"We think this gene induces emphysema by causing stem cells in the lung to die," said Dr. Jonathan Weissler, vice chairman of the department of medicine and chief of medicine at UT Southwestern University Hospital and senior author of the study, available online and due to be published in the journal Lung Cancer in October. "The cells that don't die through apoptosis would be more likely to have uncontrolled growth" and become cancerous, suggesting a genetic link between the diseases.

The gene is a known driver of several types of cancer. The degree to which PLAGL2 turns on, or is expressed, plays a role in cancer development. Previous research has demonstrated that female lung cancer patients with higher levels of gene expression had much poorer survival rates.

Increased PLAGL2 expression also aggravates emphysema. In 2009, Dr. Weissler and UT Southwestern colleagues found that high expression of this gene led to enlarged airways (alveoli) in mice. Female mice in particular were more prone to develop emphysema.

"The mice in that study developed the same type of emphysema seen in smokers despite the fact they were not exposed to cigarette smoke," said Dr. Weissler, director of the James M. Collins Center for Biomedical Rese
'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UT Southwestern research teams anti-malarial work wins international Project of the Year award
2. Drug can reverse overgrown hearts to help prevent heart failure, UT Southwestern researchers find
3. UT Southwesterns Luis Parada elected to National Academy of Sciences
4. Antidepressants may not improve all symptoms of depression, UT Southwestern researchers find
5. Limiting carbs, not calories, reduces liver fat faster, UT Southwestern researchers find
6. Pelvic-repair device developed by UT Southwestern surgeons enables minimally invasive trauma surgery
7. UT Southwestern pediatricians launch landmark childrens health study
8. Grant helps UT Southwestern researcher study causes of preterm birth
9. Dangerous blood pressure increases during exercise can be blocked, UT Southwestern researchers find
10. UT Southwestern research advances fight against kidney cancer
11. Annual sonograms are needed to verify correct IUD position, UT Southwestern obstetricians say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... WASHINGTON, DC (July 10, 2014) If you think winning ... fun for kids think again: Winning along with other mental ... each of which falls into one of 11 big fun ... that winning is all important when it comes to the ... identify and quantify what goes into this elusive conceptuntil now. ...
(Date:7/9/2014)... Boston, MA -- Vasectomy was associated with a small ... for advanced or lethal prostate cancer according to a ... The researchers found that the association remained even among ... risk of lethal cancer cannot be explained by diagnostic ... to date to look at the link between vasectomy ...
(Date:7/9/2014)... hidden ways that cells are regulated, scientists at Rockefeller ... cells more likely to metastasize. , What,s more, the ... blocking two other proteins that are normally linked to ... could have unexpected ties. , The study, which ... , points to the possibility of new cancer therapies ...
(Date:7/9/2014)... fecal transplantation is effective and safe for treating ... result of a study led by Colleen Kelly, M.D., ... at The Women,s Medicine Collaborative. The study and its ... in the American Journal of Gastroenterology . , ... has increased to epidemic proportions over the past decade. ...
(Date:7/9/2014)... in French . ... old teens, including brain structure and function, personality, life experiences ... go on to develop binge drinking within the next two ... variables such as life events and a family history of ... Whether or not the child had had a single drink ...
Breaking Medicine News(10 mins):Health News:Being a good sport ranks as the top 'fun' factor in study of youth sports 2Health News:Being a good sport ranks as the top 'fun' factor in study of youth sports 3Health News:Vasectomy may increase risk of aggressive prostate cancer 2Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:What drives a child to abuse alcohol? 2
... autism experts Fred R. Volkmar, M.D., and Ami Klin are ... identified an individual gene and a// region of a chromosome ... findings are published online in Nature Genetics and also will ... based on the largest autism genome scan done to date. ...
... could be prone to certain pregnancy related complications later on ... women carry a 60% possibility of suffering from pre-eclampsia, a ... and her unborn baby. ,The risk was ... low birth weight and whose mothers suffered pre-eclampsia during pregnancy. ...
... its ability to “bridge” interactions between other cellular proteins ... stage, a study from Burnham Institute for Medical Research ... Ph.D., and colleagues at Burnham and Royal Victoria Hospital ... to more precisely define the cancer role for the ...
... allegedly refused treatment by doctors at premier state-run Kolkata ... medical negligence to support him., ,Sk. Idrish Ali, ... approached the People for Better Treatment (PBT) set up ... refused to perform a surgery on his son for ...
... offices portray it as the hot new baby-shower gift: a ... start// privately banking a newborn's umbilical cord blood, just in ... insurance is a long shot that most mothers-to-be can safely ... more parents to donate their babies' cord blood -- so ...
... (AMANET) has secured a US$4.1million grant to strengthen institutional ... ,The fund will also be used to foster ... perspectives. , ,AMANET's communications officer, Mr. Charles ... week that the grant secured from the Bill and ...
Cached Medicine News:Health News:Autism Gene Identified by Yale and Global Consortium 2Health News:“Bridge” Protein Spurs Deadliest Stages of Breast Canc 2Health News:NRI Fights for HIV Child Who was Refused Treatment 2Health News:Parents Bank Kids' Umbilical Cord Blood 2Health News:Parents Bank Kids' Umbilical Cord Blood 3
(Date:1/14/2014)... InformEx, North America,s leading business ... hold the 30 th edition of its annual conference ... from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... chemical and specialty chemical companies will take part in the ...
(Date:1/14/2014)... Animal Emergency Critical Care, a LifeCentre partner practice, located at 165 ... the first in Loudoun County to receive ... Susan M. Barnes , Medical Director, is a well-seasoned veterinarian of ... Taylor , are avid scuba divers. "As altitude skiers and hikers, ...
(Date:1/14/2014)... 14, 2014 Equashield ( http://www.equashield.com ... drugs, today announced that it has achieved 60% ...   Equashield,s closed systems reduce the ... and other medical professionals who prepare and administer ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
... Resources, one of the world,s leading research and ... that the increased generic erosion of key drugs ... (Abbott/Sanofi-Aventis,s Depakote/Abbott,s Depakote ER, generics), combined with projected ... will cause a precipitous $2.3 billion decline in ...
... Aug. 25 Actelion Pharmaceuticals US, Inc., today ... (FDA) has approved the brand name VELETRI® for the ... available since April 2010 as Epoprostenol for Injection for ... (PAH) and PAH associated with the scleroderma spectrum of ...
Cached Medicine Technology:Through 2019, Increased Generic Erosion of Key Agents Such as Lamictal and Depakote/Depakote ER Will Cause a Precipitous $2.3 Billion Decline in the Bipolar Disorder Drug Market 2Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 2Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 3Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 4
... when rotated at 8-10 rpm. Drums ... Light weight drum of professional quality ... mechanism. For use 24 to 30 ... and Pediatric Drums that can be ...
Sterile squares of textured nylon foil for repair of the floor of the orbit....
Diagnose dry eye, assess the effectiveness of permanent punctal occlusion, collagen - dissolvable in 3-5 days, all are 2 mm long. Sterile...
Segment stand magnifiers come complete with bar magnifier to achieve a higher magnification while still maintaining a wide binocular field of view....
Medicine Products: