Navigation Links
UT Southwestern research suggests new way to ensure effectiveness of TB treatment
Date:12/28/2011

for defined non-adherence (failure to take a required dose of medication) was reached at 60 percent of the time or more.

"The first main finding in our laboratory model was that in fact non-adherence did not lead to multidrug resistance or emergence of any drug resistance in repeated studies, even when therapy failed. In fact, even when we started with a bacterial population that had been spiked with drug-resistant bacteria, non-adherence still did not lead to drug resistance," he said.

In fact, using computer simulations based on 10,000 TB patients in Cape Town, South Africa, the researchers discovered that approximately 1 percent of all TB patients with perfect adherence still developed drug resistance because they cleared the drugs from their bodies more quickly.

The body sees drugs as foreign chemicals and tries to rid itself of them, Dr. Gumbo said. A population of individuals with a genetic trait that speeds the process has been found in one area of South Africa that has a high rate of multidrug-resistant TB. In that population, patients who receive standard doses of drugs end up with concentrations in their bodies that are too low to kill the TB bacillus and drug resistance develops, he said.

A Journal of Infectious Diseases editorial that accompanies the study suggests that monitoring the levels of TB drugs in a patient's blood could be as important as monitoring compliance with therapy in contrast to current WHO guidelines.

"These data, based on our preclinical model, show that non-adherence alone is insufficient for the emergence of multidrug-resistant TB," Dr. Gumbo said. "It might be more cost-effective to measure patients' drug concentrations during treatment and intervene with dosage increases in those who quickly clear the drugs from their systems."


'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
2. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
3. UT Southwestern participates in nationwide study offering free lung tumor genetic testing
4. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
5. Novel anti-malarial drug candidate found by UT Southwestern researchers
6. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
7. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
8. UT Southwestern unveils next generation CT scanner that views whole organs in a heartbeat
9. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
10. Interferon might help asthma patients breathe easier, UT Southwestern study suggests
11. UT Southwesterns cancer center earns National Cancer Institute designation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... OH (PRWEB) September 22, 2014 A ... 2014, to set up the discovery phase for testosterone ... District Court, Northern District of Illinois. Wright & ... until mid October to submit initial disclosures about potential ... further instructed attorneys to continue negotiating the topics in ...
(Date:9/21/2014)... Dry Face Brushing brings benefits to facial ... Dry Brushing improves blood circulation and tone, feeding nutrients to ... toxins and debris from the skin , 3) Dry Face ... Body Brushing can and should be done daily, there are ... fragile and thinner, it needs less. Normal, dry and ...
(Date:9/21/2014)... a partial smoking ban at a homeless shelter can ... an indicator of exposure to cigarette smoke, and may ... new research. The University of Texas Health Science Center ... in the journal Addictive Behaviors . , The ... to 18 percent among adults, but among homeless adults, ...
(Date:9/21/2014)... on the physical activity benefits of active play, a ... for children, playing has no goal it is ... done alone or with friends, and it represents "an ... combat boredom, sadness, fear, or loneliness." "By focusing on ... several aspects of play that are beneficial to young ...
(Date:9/21/2014)... 2014 Burnaby Physiotherapists at Absolute PhysioCare ... in order to help them with preventative care. This ... clinic that will help clients understand their problem in ... active participation in the healing process. With higher knowledge ... be able to facilitate the therapy that is initiated ...
Breaking Medicine News(10 mins):Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 2Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 3Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 4Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 5Health News:Gorgeous Skin: 3 Top Benefits of Dry Face Brushing from Sublime Beauty® 2Health News:UTHealth researchers study impact of smoking ban in homeless shelter 2Health News:Narrow focus on physical activity could be ruining kids' playtime 2Health News:Burnaby Physiotherapists Now Provide Educational Information for Preventative Care 2
... 2009 As soccer continues to grow in popularity, injuries ... Certain injuries fall into gender-based patterns and new ... causes that could help lead to better treatment, or ... Data presented at this year,s American Orthopaedic Society for ...
... MAP Pharmaceuticals, Inc. (Nasdaq: MAPP ) today announced ... license agreement with AstraZeneca related to the company,s Unit Dose ... July 8, 2009, effective immediately. All rights licensed to ... MAP Pharmaceuticals plans to suspend development of UDB, which did ...
... New Zealand, July 9 ZyGEM Corp. Ltd., a ... other life sciences applications, today announced the availability of ... GEM(R) Bacteria DNA extraction kit is capable of producing ... bacterial species, including mixed or unknown sample types. ...
... Tested on animals, liquid would be administered externally , ... developed a pain-free vaccination that might thwart ear infections ... ear infections, and surgery is often recommended for children ... microorganisms and the invasive nature of the surgical procedure ...
... July 9 Universal Health Services, Inc. (NYSE: ... to pay a cash dividend of $0.08 per share on ... 1, 2009. , , Universal Health Services, Inc. is ... subsidiaries, acute care and behavioral health hospitals, and ambulatory centers ...
... , TAMPA, Fla., July 9 With healthcare ... chairman and chief executive officer of Health Integrated, a leading ... for companies that can clearly offer solutions to drive down ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20090709/FL43703LOGO ...
Cached Medicine News:Health News:Motion analysis helps soccer players get their kicks 2Health News:Motion analysis helps soccer players get their kicks 3Health News:MAP Pharmaceuticals Announces Termination of Pediatric Asthma Collaboration 2Health News:MAP Pharmaceuticals Announces Termination of Pediatric Asthma Collaboration 3Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 2Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 3Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 4Health News:Vaccine May Someday Thwart Ear Infections 2Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 2Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 3Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 4Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 5
(Date:9/19/2014)... Sept. 19, 2014 Research and Markets ... (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast ... the purposes of this report, the human microbiome market is ... human microbiome market is expected to be valued as $294 ... CAGR of 22.3% within the forecast period of 2019-2023. The ...
(Date:9/19/2014)... 19, 2014 Five MinuteClinic walk-in medical clinics are opening ... metropolitan area. Three clinics opened in Memphis ... clinic will be added in Springfield on ... is expected to open October 22.  MinuteClinic is the largest ... the United States . The Memphis ...
(Date:9/19/2014)... DIEGO , Sept. 19, 2014  Lpath, ... leader in bioactive lipid-targeted therapeutics, announced today that ... 3,605,042 registered shares of common stock and 3,605,042 ... combined purchase price for one registered share of ... one unregistered share of common stock will be ...
Breaking Medicine Technology:Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Lpath, Inc. Announces $12.5 Million Registered Direct Offering 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 3
... closes various plastic primary and secondary tubes in ... heights and diameters can be sealed in one ... send-outs. The integration into other PVT Systems (e.g. ... and High Throughput Sorter RSD ProVolume ) ...
... MGB Alert Detection Reagents provide molecular ... PCR based assays. By using our MGB ... analysis, Nanogen is now able to provide ... nucleic acid sequences of specific organisms or ...
... for the detection of two genetic ... mutation on the Factor V (Leiden) ... the Prothrombin gene. Laboratories may use ... *Analyte Specific Reagents. Analytical ...
... the latest and most advanced fecal occult ... line. An immunochemical FOBT (iFOBT) with high ... proven to detect bleeding associated with more ... Because of its superior specificity for lower ...
Medicine Products: