Navigation Links
UT Southwestern research advances fight against kidney cancer
Date:3/30/2011

ing HIF is sufficient to block cells from using oxygen. It also indicates that there are no other pathways that can allow the use of available oxygen when HIF is active."

In a related study, Dr. Brugarolas examined the effectiveness of a specific glycolytic inhibitor, 2-deoxy-D-glucose (2DG), in treating a rare form of kidney cancer. The case study, available in the March 1 issue of Nature Reviews Urology, details efforts to develop a personalized treatment plan for a patient who presented with an uncommon kidney cancer type when she was 24. Without any familial predisposition for kidney or other cancers, the patient was found to have a mutation in a gene called fumarate hydratase, which has been found to be mutated in approximately 100 families worldwide and which confers a strong predisposition to kidney cancer. The mutation was a novel mutation, and the patient is likely to have been the founder, Dr. Brugarolas said.

The gene encodes an enzyme which is important for cells to be able to use oxygen and generate energy, and studies showed that the enzyme was completely inactive in the tumor. The patient, who had an advanced case of cancer, underwent surgery and then standard treatment with mTORC1 inhibitors. After five months, however, her tumor progressed and there were no other proven treatments available. Given this situation, Dr. Brugarolas looked for options to exploit what was known about the tumor. After a discussion with the UT Southwestern Institutional Review Board, the Food and Drug Administration and the drug manufacturer, Dr. Brugarolas managed to secure for his patient a drug in development, 2DG, which previously had been used only in clinical trials.

Because the tumor was deficient in fumarate hydratase, researchers speculated that 2DG would block glycolysis and kill tumor cells, as it had in the laboratory. The drug, however, failed to produce the same results for the patient, who later died. The patient had given p
'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
2. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
3. UT Southwestern participates in nationwide study offering free lung tumor genetic testing
4. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
5. Novel anti-malarial drug candidate found by UT Southwestern researchers
6. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
7. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
8. UT Southwestern unveils next generation CT scanner that views whole organs in a heartbeat
9. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
10. Interferon might help asthma patients breathe easier, UT Southwestern study suggests
11. UT Southwesterns cancer center earns National Cancer Institute designation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... Utah (PRWEB) May 18, 2013 ... on insurance agents’ role in Marketplaces . ... to traditional employer sponsored health benefits, is the ... and health reimbursement arrangements . , ... Health and Human Services (HHS) recently released a ...
(Date:5/18/2013)... The “World Healthcare IT Market: Trends & Forecast (2010 ... restraints, and opportunities in North America, Europe, Asia, & ... 89 market data tables , ... , http://www.marketsandmarkets.com/Market-Reports/healthcare-information-technology-market-136.html , Early buyers ... healthcare IT market is expected to grow from $99.6 ...
(Date:5/18/2013)... York, New York (PRWEB) May 18, 2013 ... to mount in courts throughout the country, Bernstein Liebhard ... metal-on-metal hip replacement patients often suffer tissue damage before ... the study, which according to Science Daily will appear ... metal-on-metal hip replacement recipients underwent MRI screens of their ...
(Date:5/18/2013)... The “Sleep Apnea Diagnostic & Therapeutic Devices ... Servo-Ventilation (ASV), Oral Appliances, Nasal EPAP, Neurostimulation] Global End-user ... studies the major market drivers, restraints, and opportunities in ... , Browse , 147 market ... , 318 pagesand in-depth TOC of ...
(Date:5/18/2013)... The Ayurvedic practitioner program will be offered ... West. Program is available in Mexico via Live Internet ... modality practiced for over 5,000 years. In Ayurvedic medicine ... begins when an individual lives in harmony with their ... Ayurveda aims to heal an individual in all levels ...
Breaking Medicine News(10 mins):Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 2Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 3Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 4Health News:Healthcare IT Market to reach US$ 162.2 Billion by 2015 at a CAGR of 10.2% - New Report by MarketandMarkets 2Health News:Healthcare IT Market to reach US$ 162.2 Billion by 2015 at a CAGR of 10.2% - New Report by MarketandMarkets 3Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 2Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 3Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 4Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 2Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 3Health News:Ayurveda Training in Mexico Offered by Escuela de Ayurveda de California, a Leading Institution in the West 2
... 29 Varian Medical,Systems (NYSE: VAR ) ... equipment for a major new hospital in,Portsmouth, England. ... the investment waves of the UK government,s Cancer ... will receive four high-energy,Clinac(R) iX linear accelerators equipped ...
... American Legacy Foundation(R) Finds Tobacco-Free,States Spend Less on ... could spend nearly $10 billion less within five ... new study released today by the,American Legacy Foundation ... cut Medicaid costs by 5.6 percent., The ...
... of the hip is a growing problem that will ... have reported on risk factors for developing OA, but ... prognosis. A new study published in the December issue ... patients with hip pain to determine their disease progression ...
... (NYSE:,CNO) said today that it has agreed to implement a ... (LTCG) for certain,back-office functions of the long term care business ... year that it was,considering this solution. Under the agreement:, ... call center and the processing ...
... Nov. 29, WASHINGTON, Nov. 28 The following ... WHAT: A press briefing by conference call with experts ... as recently issued,proposals by several of the candidates for ... the new estimates of the AIDS crisis mean for ...
... in a key piece of DNA seem important, scientists say ... contribute to disparities in colorectal cancer rates between ethnic and ... team, led by investigators at the University of Pittsburgh, analyzed ... found that people who have two "T" copies of the ...
Cached Medicine News:Health News:Varian Image-Guided Treatment Machines Selected for Major New Hospital on South Coast of England 2Health News:Varian Image-Guided Treatment Machines Selected for Major New Hospital on South Coast of England 3Health News:Smokers Cost Medicaid System Nearly $10 Billion 2Health News:Smokers Cost Medicaid System Nearly $10 Billion 3Health News:Identifying patients at high risk for total hip replacement 2Health News:Conseco to Implement Systems and Operational Solution From Long Term Care Group 2Health News:Conseco to Implement Systems and Operational Solution From Long Term Care Group 3Health News:Conseco to Implement Systems and Operational Solution From Long Term Care Group 4Health News:Conseco to Implement Systems and Operational Solution From Long Term Care Group 5Health News:Genes May Explain Role of Race in Colon Cancer Risk 2
(Date:5/17/2013)... Ill. , May 17, 2013  Sony Biotechnology Inc. ... Sorter 8-well strip holder and 130um sorting chip.  Sony will ... collected on its new SH800 Cell Sorter, the EC800 flow ... commercial tutorials at CYTO 2013, which will be held at ... San Diego, California , from May 20 ...
(Date:5/17/2013)... 2013  TechAtlas Group has announced the release ... map for the Chronic Kidney Disease (CKD) market. ... with drugs and devices currently on the market ... (Logo:  http://photos.prnewswire.com/prnh/20130517/NE16011LOGO ) ... - renal denervation , diabetic nephropathy - ...
(Date:5/17/2013)... Fuse Science, Inc. (OTCQB: DROP), ( www.fusescience.com ) ... new, patent-pending technologies poised to redefine how consumers receive energy, ... a business update teleconference and webcast for shareholders and the ... 4:30 PM ET. Fuse Science, Inc. CEO, ... and will be joined by Rubin Hanan ...
Breaking Medicine Technology:Sony Delivers New Technology for Science to CYTO 2013 2TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2Fuse Science, Inc. to Hold Business Update Webcast and Teleconference on May 22nd 2
... Vanda Pharmaceuticals Inc. (NASDAQ: VNDA ... affiliate of Vanda,s sublicensor Novartis Pharma AG, has ... injectable (or depot) formulation of Fanapt® (iloperidone).  This ... the safety and pharmacokinetic profiles of two different ...
... ROME, April 8, 2011 Noverca – the first and ... offerings by announcing its presence in the Health and ... to support diabetes treatment has been developed and launched thanks ... of N o verca) and Fatebenefratelli ...
Cached Medicine Technology:Vanda Pharmaceuticals Announces Commencement of Clinical Study of Long-Acting Injectable Formulation of Fanapt® 2Vanda Pharmaceuticals Announces Commencement of Clinical Study of Long-Acting Injectable Formulation of Fanapt® 3EXTENDED HEALTH: Noverca Enters the World of Healthcare 2
... single use, disposable device that is specifically ... after the needle is in place. ,It ... from accidental movement by contact, during patient ... patient confidence in your staff and your ...
... for high volume laboratories, the AU2700 automates ... time. This high-speed analyzer delivers true random ... test results per hour (up to 2133 ... tests on-board. Consolidate with Olympus 122 test ...
... The EPO ELISA is intended for the ... This assay is intended for in vitro diagnostic ... anemias and polycythemias. With the advent of the ... to increase red blood cell mass, an erythropoietin ...
... innovative PoleStar N20, exclusively distributed by ... MRI. Combining intra-operative imaging with ... system, PoleStar N20 is one of ... today. , , Exceptional image quality ...
Medicine Products: